Serum interleukin-6 levels are increased in post-herpetic neuralgia: a single-center retrospective study

Lin, Ding Yu; Zhong, Changyang; Jiang, Quanlong; Liu, Yuan

doi:10.1016/j.abd.2022.03.007

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Therefore, the data of these studies should be interpreted carefully. Among the reported studies, Ding Lin et al 31 found no significant difference in IL-10 levels between PHN and control groups, which is inconsistent with the studies of ShenMei Zhu et al 22 and Wei Chen et al 75 and the reason for the difference may be due to the use of different analytical methods. Yanrong Yuan et al 32 reported that CD8+ T cells did not show a remarkable difference between the two groups, which may be because 129 patients were included in the case group while only 31 patients were included in the control group, causing an insufficient statistical test.…”

Section: Discussionmentioning

confidence: 82%

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Yue,

Yao

2024

JPR

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Background The neurocutaneous disease caused by the reactivation of varicella-zoster virus (VZV) is called herpes zoster (HZ). The virus remains in the spinal cord back root after the chickenpox disappears. Diminished immune function can reactivate VZV, causing severe neuropathic pain that can last for months or even years, leading to postherpetic neuralgia (PHN), which severely affects the patient’s quality of life. Much literature compares various cytokine levels in the body fluids HZ and PHN patients; however, no studies comprehensively evaluate them. Methods The Cochrane Library, PubMed, Web of Science, and Medline were screened for studies on cytokine levels in body fluids of HZ and PHN patients in the English language. Healthy individuals were selected as the control group, and the standardized mean difference (SMD) between the case and control groups was imputed using a fixed-effects or random-effects model and expressed as a 95% confidence interval (CI). The Newcastle-Ottawa Scale (NOS) was used to assess article quality. Results This meta-analysis included 13 articles with 1373 participants. Compared with the control group, the HZ group had significantly higher levels of interleukin (IL)-4, IL-6, IL-10, Hcy, and C-reactive protein (CRP), whereas the levels of CD3+ T and CD4+ T lymphocytes were reduced. Additionally, PHN patients had significantly higher levels of IL-6 and IL-1β compared with the control group. Conclusion This meta-analysis provides compelling evidence that CRP, Hcy, IL-1β, IL-4, IL-6, IL-8, and IL-10 are associated with the genesis and development of HZ and PHN. These markers can be used to improve the diagnosis and treatment of these diseases.Furthermore, for making the results more convincing, it is necessary to harmonize sample acquisition techniques and analytical methods and also require larger, more rigorously designed studies with broader subgroups and sex/age-matched controls.

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Section: Discussionmentioning

confidence: 82%

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Yue,

Yao

2024

JPR

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“…The level of IL-2 in patients with pathological neuralgia was higher than that in healthy individual, and the level of IL-6 was lower. [34] The study [35] found that the level of serum IL-6 in patients with PHN increased, which can be used as an indicator of the severity of PHN. This study suggests that AHP can increase serum IL-10 levels in patients with PHN and reduce serum IL2 and IL6 levels in patients with PHN.…”

Section: Discussionmentioning

confidence: 99%

Acupoint herbal patching for postherpetic neuralgia: A systematic review and meta-analysis

Pu,

Lu,

et al. 2024

Medicine

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Background: This study aimed to systematically evaluate the clinical effectiveness and safety of acupoint herbal patching in the treatment of postherpetic neuralgia. Methods: Eight databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wan-Fang Database, China Biomedical Literature Service System, and Chongqing VIP Chinese Science were searched. The search time was set to October 2023. Two researchers independently screened the literature according to the inclusion and exclusion criteria; extracted the basic information, acupoints, Chinese herbal medicine, pain score, sleep score, depression score, and other information of the subjects, and independently assessed the risk of bias by 2 researchers. Meta-analysis of the included studies was performed using the StataMP 16 software. Results: Fifteen studies with 1362 participants were included in this meta-analysis. Ashi is the acupoint frequency at the forefront, and Borneol is the Chinese herbal medicine frequency at the forefront. The acupoint herbal patching group showed significant improvements in visual analog score (SMD: −2.09; 95% Cl: −2.77, −1.42; P < .001), sleep score (SMD: −1.58; 95% Cl: −2.11, −1.05; P < .001), depression score (SMD: −1.61; 95% Cl: −2.22, −0.99; P < .001), Chinese medicine syndrome score (SMD: −2.32; 95% Cl: −2.84, −1.80; P = .06), dermatology life quality index (weighted mean differences: −4.11; 95% Cl: −4.58, −3.63; P = .98), and related laboratory indicators compared to the control group, and the total effective rate was significantly higher (relative risk: 1.20; 95% confidence interval: 1.15, 1.26; P = .99) than the control group. Two studies reported adverse reactions, but the 2 groups were not statistically significant. Conclusions: Acupoint herbal patching intervention in postherpetic neuralgia is effective in improving the pain, sleep, anxiety, depression, quality of life of patients, and related laboratory indicators.

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“…Specifically, IL-6, which is closely linked to inflammaging and sarcopenia, has been identified in multiple studies as being associated with PHN [ 36 , 37 , 38 ]. Zhu et al [ 36 ] reported that IL-6 concentrations in patients with PHN were elevated compared to those in patients with HZ who did not develop PHN.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the inflammatory response, especially that involving IL-6, during the acute phase of HZ is implicated in hyperalgesia and the onset of PHN. Numerous studies have described PHN as a form of neuropathic pain that is potentially linked to different types of nervous system impairment [ 37 , 39 ]. The production of IL-6 by macrophages, mast cells, lymphocytes, neurons, and glial cells is typically minimal and aids in the normal growth and repair processes of the nervous system, whereas elevated IL-6 levels can lead to nervous system damage [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Psoas: Lumbar Vertebral Index (PLVI) with Postherpetic Neuralgia in Patients Aged 60 and Older with Herpes Zoster

An,

Chae,

Lee

et al. 2024

JCM

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Background/Objectives: The psoas: lumbar vertebral index (PLVI) is a simple and convenient measure to assess central sarcopenia. Recent studies have utilized the psoas area to indirectly assess sarcopenia and frailty, exploring their associations with various health outcomes. This study aims to investigate the relationship between the PLVI and postherpetic neuralgia (PHN) in patients aged 60 years and above following a herpes zoster (HZ) infection. Methods: We conducted a retrospective analysis of data from 351 patients (≥60 years) who developed HZ between January 2019 and December 2023; the patients were divided into two groups based on the presence or absence of PHN after HZ onset. Results: The analyses using receiver operating characteristic curves revealed a value for the area under the curve of 0.813 for PLVI and 0.769 for the modified frailty index (mFI). In a multivariate logistic regression analysis, numerical rating scale scoring, a low PLVI, and a greater number of categorical mFI variables (adjusted odds ratio: 1.30, 3.27, and 2.46, respectively) were found to be significant independent predictors of PHN. Conclusions: Our findings highlight the association between a low PLVI and PHN in an older population. The PLVI may have potential as a predictive tool for PHN in older patients with HZ, but further research is needed to confirm these results.

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Serum interleukin-6 levels are increased in post-herpetic neuralgia: a single-center retrospective study

Cited by 6 publications

References 21 publications

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Acupoint herbal patching for postherpetic neuralgia: A systematic review and meta-analysis

Association of Psoas: Lumbar Vertebral Index (PLVI) with Postherpetic Neuralgia in Patients Aged 60 and Older with Herpes Zoster

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