2012
DOI: 10.1016/j.cca.2012.05.007
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Serum interleukin‐6 levels in response to methotrexate treatment in psoriatic patients

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Cited by 35 publications
(26 citation statements)
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“…Following treatment with methotrexate, adipose tissue from obese mice produced less proinflammatory (TNF‐α, IL‐6, leptin) and more anti‐inflammatory mediators (adiponectin and IL‐10) associated with reduced macrophage infiltration and inflammation (DeOliveira et al, ). In addition, methotrexate down‐regulates the expression of adhesion molecules (ICAM‐1, E‐selectin, VCAM‐1) in human biopsies rich in inflammatory infiltrate (Dahlman‐Ghozlan et al, ) and circulating levels of IL‐6 in psoriatic patients (Elango et al, ). All these activities support a potential effect of methotrexate in the treatment of atherosclerosis.…”
Section: Ongoing Rctsmentioning
confidence: 99%
“…Following treatment with methotrexate, adipose tissue from obese mice produced less proinflammatory (TNF‐α, IL‐6, leptin) and more anti‐inflammatory mediators (adiponectin and IL‐10) associated with reduced macrophage infiltration and inflammation (DeOliveira et al, ). In addition, methotrexate down‐regulates the expression of adhesion molecules (ICAM‐1, E‐selectin, VCAM‐1) in human biopsies rich in inflammatory infiltrate (Dahlman‐Ghozlan et al, ) and circulating levels of IL‐6 in psoriatic patients (Elango et al, ). All these activities support a potential effect of methotrexate in the treatment of atherosclerosis.…”
Section: Ongoing Rctsmentioning
confidence: 99%
“…Considering the cost, it would be expedient to predict the chance of successful treatment before the start of ustekinumab therapy. Studies have focused on alterations in serum proteins during treatment, and have correlated these with the clinical response to systemic treatment including methotrexate and ustekinumab . However, only a limited number of cytokines were studied and no predictors of therapeutic response were found.…”
Section: Up‐ (Red) and Downregulated (Green) Heatmap Cytokines Basedmentioning
confidence: 99%
“…Studies have focused on alterations in serum proteins during treatment, and have correlated these with the clinical response to systemic treatment including methotrexate and ustekinumab. [2][3][4][5][6] However, only a limited number of cytokines were studied and no predictors of therapeutic response were found.…”
mentioning
confidence: 99%
“…In a clinical study with psoriatic patients, treatment with methotrexate downregulated serum IL-6 levels. Since this cytokine is known to be over-expressed in psoriasis, a reversal of this may result in a therapeutic effect, suggesting this type of effect to be positive for psoriasis [21]. …”
Section: Discussionmentioning
confidence: 99%