Serum interleukin‐6, procalcitonin and C‐reactive protein levels in subjects with active Behçet's disease

Adam, Bahattin; Çalıkoğlu, Emel

doi:10.1111/j.1468-3083.2004.00907.x

Cited by 67 publications

(50 citation statements)

References 16 publications

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“…19 Sayi nalp et al simiarly fo und that se rum le vels of IL-1 be ta, IL-2 and IL-6 in the pa ti ents with BD we re si mi lar to the con trol gro up, but se rum le vels of sIL-2R and TNF-α we re hig her in pa ti ents with BD com pa red to con trols. 20 Our fin dings on se rum IL-6 le vels are inconsistent with tho se of Me ge, Turan, Ya ma ka wa, Na wa ta, Ham za o u i, Eve rek li og lu, Bar dak, Adam, Ak de niz et al, however they are consistent with tho se of al-Da la an, and Sa yi nalp et al 8,[11][12][13][14][15][16][17][18][19][20] The only study in li te ra tu re in which se rum adi no pec tin le vel is in ves ti ga ted in BD was per formed by Oguz et al 22 In this study, se rum adi no pectin le vels we re not sig ni fi cantly dif fe rent in BD in com pa ri son to the he althy con trol gro up. The ir pati ent gro up ma ni fes ted si mi la ri ti es to our pa ti ents be ca u se 86.8% of the pa ti ents used colc hi ci ne, 2.6% used ste ro id and 5.3% used im mu no sup res si ves.…”

Section: Discussionsupporting

confidence: 53%

“…16 Adam et al fo und sig ni fi cantly hig her le vels of CRP and IL-6 in the ac ti ve BD pati ent gro up in com pa ri son to the con trol gro up. 17 Ak de niz et al fo und sig ni fi cantly hig her se rum levels of IL-6, IL-8 and TNF-α in BD in com pa ri son to the con trol gro up. 18 On the ot her hand, al-Da la an et al re por ted that se rum le vels of IL-6, TNF-α and IFN-γ we re not sig ni fi cantly ele va ted in pa ti ents with BD.…”

Section: Discussionmentioning

confidence: 99%

“…Many in vi vo stu di es ha ve de mons tra ted that TNF-α, IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, G-CSF and IFN-γ were all im por tant com po nents of the pro inf lam ma tory res pon se in BD. 8,[11][12][13][14][15][16][17][18] Me ge et al fo und that the spon ta ne o us sec re ti on of TNF-α, Turkiye Klinikleri J Med Sci 2010;30 (6) IL-6 and IL-8 by mo nocy tes was sig ni fi cantly incre a sed in pa ti ents with ac ti ve BD. 11 Tu ran et al re por ted that IL-10 and IL-12 were in cre a sed in BD and IL-12 had a cor re la ti on with ac ti va ti on.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 Stu di es on cyto ki ne pro fi le in BD have yielded conf lic ting re sults. 8,[11][12][13][14][15][16][17][18][19][20] Adi po nec tin is an adi pocy to ki ne which was de fi ned first and it is the major pro te in produced by the adi pocy tes. It is a cen tral re gu la tory pro te in con trol ling li pid and car bohy dra te me ta bo lism in many physi o lo gic path ways and it me di a tes va ri ous vas cu lar pro ces ses.…”

mentioning

confidence: 99%

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Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

Etem¹,

Yildirmak²,

Önalan³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Beh çet's di se a se (BD) is a chro nic syste mic inf lam ma tory di se a se and its etio pat ho ge ne sis still re ma ins unk nown. Cyto ki nes play a ro le in im mu ne res pon se and inf lam ma tory re ac ti ons. The aim of this study is to de ter mi ne the le vels of pro inf lam ma tory cyto ki ne in ter le ukin-6 (IL-6) and an ti-inf lam ma tory cyto ki ne adi po nec tin in the sera of pa ti ents with BD and to assess their im por tan ce as bi o lo gi cal mar kers for di se a se ac ti vity. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Forty-four BD pa ti ents [19 ma les, 25 fe ma les, age: 35.65 ± 10.84 yrs (me an ± stan dart de vi a ti on) (SD)] and 25 he althy con trols (10 ma les, 15 fe ma les, age: 29.80 ± 8.20 yrs) we re inc lu ded in the study. Pa ti ents we re divided into ac ti ve or inac ti ve gro ups ac cor ding to the ir cli ni cal and la bo ra tory fin dings (acti ve, n= 21; inac ti ve, n= 23). We de ter mi ned se rum IL-6 le vels using the che mi lu mi nes cen ce method, and se rum adi po nec tin le vels by ELI SA met hod. Re sults we re ex pres sed as me an ± stan dard er ror (SE). R Re e s su ul lt ts s: : Se rum le vels of IL-6 and adi po nec tin in BD pa ti ents (n= 44) (5.24 ± 0.84 pg/mL; 22.31 ± 1.71 µg/mL, res pec ti vely) we re si mi lar to the con trol gro up (n= 25) (4.59 ± 1.01 pg/mL; 21.68 ± 1.91 µg/mL, res pec ti vely). No sig ni fi cant dif fe ren ce was fo und in IL-6 and adi po nec tin le vels bet we en the ac ti ve (n= 21), inac ti ve (n= 23) and con trol (n= 25) gro ups. C Co on nc c l lu u s si i o on n: : In pa ral lel with the pre sen ce of inf lam ma ti on and in cre a sed CRP, eryt hrocy te se di men ta ti on ra te and white blood cell co unt, hig her IL-6 and lo wer adi po nec tin le vels were ex pec ted in ac ti ve BD pa ti ents com pa red to the con trols. However, they were found to be si mi lar in all gro ups. We conc lu de that on go ing an ti-inf lam ma tory tre at ment sho uld be ta ken in to con si de ra ti on whi le in ter pre ting the cyto ki ne levels in the se pa ti ents. K Ke ey y W Wo or rd ds s: : Beh cet's syndro me; adi po ki nes; in ter le u kin-6 Ö ÖZ ZE ET T A Am ma aç ç: : Beh çet has ta lı ğı (BH), kro nik sis te mik inf la ma tu ar bir has ta lık olup eti yo pa to ge ne zi he nüz bi lin me mek te dir. İmmun ce vap ve inf la ma tu var sü reç iliş ki sin de si to kin ler rol oy na mak tadır lar. Bu ça lış ma nın ama cı, BH'lı has ta la rın se rum la rın da pro-inf la ma tu ar bir si to kin olan IL-6 ile an ti-inf la ma tu ar si to kin olan adi po nek ti nin se vi ye le ri ni öl çe rek, bun la rın has ta lı ğın ak ti vi te sin de bi yo lo jik be lir teç ola rak et ki le ri ni be lir le mek tir. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ça lış ma ya 44 BH'lı has ta (19 er kek, 25 ka dın, yaş or ta la ma sı 35.65 ± 10 yıl) ve kon trol gru bu ola rak da 25 sağ lık lı ki şi (10 er kek, 15 ka dın, yaş or ta la ma sı 29.80 ± 8.20 yıl) alın mış tır. Has ta lar kli ni...

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

Etem¹,

Yildirmak²,

Önalan³

et al. 2010

Turkiye Klinikleri J Med Sci

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“…Patogenezinde; genetik yatkınlık, tetikleyici infeksiyonlar ve çevresel faktörlerin doğal ve edinsel bağışıklık sistemini aktive ettikleri düşünülmektedir 1 . IL-6 (interlökin 6), nötrofil sayımı, eritrosit sedimantasyon hızı (ESH) ve C-reactive protein (CRP) düzeylerinin hastalığın aktif dönemlerinde daha yüksek olduğu bildirilmiş ve IL-6 hastalık aktivitesi ile ilişkilendirilmiştir 2,3 . Visfatin yeni tanımlanmış bir adipositokin olup proinflamatuvar etkiler göstermektedir 4 .…”

Section: Introductionunclassified

Behçet Hastalarında Serum Visfatin Seviyeleri Ve Hastalık Aktivitesi İle İlişkisi

Altunel¹,

Tatlıcan²,

Oktay³

et al. 2014

TURKDERM

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Background and Design:Behçet's disease (BD) is a chronic inflammatory disorder. Genetic susceptibility, triggering infections and environmental factors that alter innate and acquired immunity are accused in its pathogenesis. Visfatin is a novel adipocytokine which exerts proinflammatory effects. In the present study, by comparing serum visfatin levels in patients with active BD with those in patients with inactive BD and healthy controls, we investigated the role of visfatin in the inflammatory process of BD. Materials and Methods:We enrolled 26 patients with active BD, 26 with inactive BD and 26 healthy controls in the study. Serum visfatin levels were analyzed by an enzyme-linked immunosorbent assay. White blood cell (WBC) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) levels were measured simultaneously and their correlation with visfatin levels were examined. Results: Age and gender distributions did not differ between the study groups (p=0.736 and p=1.00, respectively). Serum visfatin levels were significantly higher in patients with active BD (17.80±5.70 ng/mL) and inactive BD (12.80±2.90 ng/mL) than in controls (8.90±4.20 ng/mL), (p=0.00 for both comparisons). Active BD patients had significantly higher visfatin levels when compared to inactive BD patients (p=0.00). In all study groups, visfatin levels were positively correlated with WBC count, ESH, CRP, and IL-6 levels. Conclusion: Our results support the idea that visfatin plays a role in the inflammatory process of BD and suggest that visfatin may be a novel activity marker in BD. (Turkderm 2014; 48: 82-6)

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Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcetʼs disease

Jung

Yoon

Lee

et al. 2011

Inflammatory Bowel Diseases

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Serum interleukin‐6, procalcitonin and C‐reactive protein levels in subjects with active Behçet's disease

Abstract: The results of our study suggest that serum CRP and IL-6 levels are elevated in patients with active BD, but that serum PCT values are not elevated in these patients.

Cited by 67 publications

References 16 publications

Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

Behçet Hastalarında Serum Visfatin Seviyeleri Ve Hastalık Aktivitesi İle İlişkisi

Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcetʼs disease

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