Serum interleukin measurement may help identify thyroid cancer patients with active disease

Martins, Mariana Bonjiorno; Marcello, Marjory Alana; Batista, Fabiano Bianchini; Peres, Karina Colombera; Meneghetti, Murilo; Ward, Mirela Andrea Latham; Etchebehere, Elba; Assumpção, Lígia Vera Montali da; Ward, Laura Sterian

doi:10.1016/j.clinbiochem.2017.10.003

Cited by 22 publications

(26 citation statements)

References 36 publications

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“…1. Eighteen of these 29 studies are published in Chinese [14][15][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] and the rest are published in English [33][34][35][36][37][38][39][40][41]. Nineteen studies were conducted in China, two in India and two in Turkey.…”

Section: Search Results and Characteristics Of Included Studiesmentioning

confidence: 99%

“…Provatopoulou X et al [35] found that serum IL-6 were significantly higher in malignant and benign thyroid diseases compared to healthy controls. However, other studies show a different result that no significance different of IL-6 was found between thyroid cancer and non-thyroid cancer [16,23,[35][36]41]. A limited sample size, different inclusion criterias, different population characteristics, or different pathological type of thyroid cancer may explain such a difference.…”

Section: Il-6 a Multifunctional Cytokine Plays Important Roles In Dmentioning

confidence: 88%

“…Tumor cells including esophageal cancer, lung cancer, colorectal cancer and melanoma were found have the function of autocrine IL-6, which can affect the growth and proliferation of tumor cells and participate in the tumor growth and metastasis by acting on the membrane receptors on the cell surface [66]. Also, IL-6R was found associated with the 11 characterization of thyroid nodules' malignancy and tumor aggressiveness [41]. In addition, Iliopoulos D et al [67] found that Src (non-somatic tyrosine kinase family oncogene) can induce the normal epithelial cell transformation by activating NF-kB, and this transformation take part in tumorigenesis.…”

Section: Il-6 a Multifunctional Cytokine Plays Important Roles In Dmentioning

confidence: 98%

“…Of the 29 included studies, 9 reported the level of serum IL-6 in patients with thyroid carcinoma and control subjects [20,23,28,32,[35][36]38,[40][41]. Due to the large heterogeneity of the merged SMD 7 values of serum IL-6 level by the heterogeneity analysis (heterozygosity test, Chi 2 =334.36, P<0.00001, I 2 = 96%), random-effect model was used to pooled the SMD values, and the pooled effect size in favor of control subjects is 1.04 (95% CI 0.40 to 1.67, P=0.001) ( Fig.…”

Section: Il-6 and Thyroid Carcinomamentioning

confidence: 99%

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Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

Zhao

Wen

Wang

et al. 2020

Preprint

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Background: The incidence of thyroid carcinoma is on the rise all the world. Some studies have suggested that the change of adipokines can even induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adipokines and thyroid carcinoma. Methods: Databases—PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries were searched. A meta-analysis was performed with sufficiently homogeneous studies. Twenty-nine articles were finally included for analysis. Results: The level of serum tumor necrosis factor-alpha (TNF-α) [standardized mean difference (SMD) =1.31, 95% confidence interval (95% CI): 0.35 to 2.28, I 2 =98%, P =0.008] and positive rate of tissue’s TNF-α [odds ratios (OR) =11.80, 95% CI: 5.88 to 23.66, I 2 =0%， P <0.00001] in thyroid carcinoma are significantly higher than those in control. The serum interleukin-6 (IL-6) in patients with thyroid carcinoma is higher than that in control (SMD=1.04, 95% CI: 0.40 to 1.67, I 2 =96%, P =0.001). No significant difference of the positive rate of IL-6 in tissues between carcinoma and control is found (OR=1.23, 95% CI: 0.62 to 2.43, I 2 =86%, P =0.55). The positive ratio of leptin in tissue is significantly associated with the risk of thyroid carcinoma (OR=12.21, 95% CI: 3.36 to 44.40, I 2 =85%, P <0.00001). However, after analyzing three studies on the expression of adiponectin, no significant difference is found in serum adiponectin level between thyroid carcinoma and the control ( P =0.81). Conclusions: Adipokines play an important role in the occurrence and development of thyroid carcinoma, especially TNF-α, IL-6 and leptin. However, the effect of adiponectin on thyroid carcinoma needs further research.

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Section: Search Results and Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Il-6 a Multifunctional Cytokine Plays Important Roles In Dmentioning

confidence: 88%

Section: Il-6 a Multifunctional Cytokine Plays Important Roles In Dmentioning

confidence: 98%

Section: Il-6 and Thyroid Carcinomamentioning

confidence: 99%

See 2 more Smart Citations

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

Zhao

Wen

Wang

et al. 2020

Preprint

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“…Researchers have focused on the antitumor effect of IL-12 or on the impacts of IL-12A (P35) and IL-12B (P40) gene polymorphisms on the progression of cancer [12][13][14]. The role of the IL-12 family on thyroid cancer was described in only one study, which reported a decrease in serum IL-12 expression in thyroid cancer compared with that in healthy controls; however, IL-12 expression was significantly higher in patients with active disease than in those who were disease free [15]. Few studies have reported an association between the IL-12 family and the prognosis of patients with cancer.…”

Section: Introductionmentioning

confidence: 99%

High Expression of Interleukin-12A and Its Association with the Clinicopathology and Prognosis of Differentiated Thyroid Cancer

et al. 2020

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Background: The inflammatory microenvironment is closely related to the occurrence and development of cancer. Members of the interleukin-12 (IL-12) cytokine family play synergistic or antagonistic roles in the tumor microenvironment, in the form of classic heterodimers or newly discovered monomers or homodimers. Objective: The purpose of this study was to investigate the association between IL-12A and the clinicopathology and prognosis of differentiated thyroid cancer (DTC). Methods: A total of 101 pathologically confirmed DTC patients were included in this study. Immunohistochemistry was performed to assess IL-12A expression in DTC and corresponding paracancerous tissues. The associations of IL-12A with clinicopathology and prognosis were evaluated. Results: IL-12A was expressed in both normal thyroid tissues and DTC, but its expression level was significantly higher in DTC than in normal thyroid tissues (p < 0.001). IL-12A was positively correlated with tumor size (p = 0.027), risk stratification (p = 0.020), and TNM (Tumor-Node-Metastasis) stage (p = 0.024), but not with age, sex, patho-logical type, multifocality, extrathyroid extension, lymph node metastasis, and distant metastasis (all p > 0.05). Lymphocytic thyroiditis was found in 26/101 patients (25.7%), which was negatively associated with IL-12A expression (p = 0.018). Multivariate logistic regression analysis showed that risk stratification was the significant independent predictor of IL-12A expression. The rate of disease persistence or recurrence (P&R) was 13/101 (12.9%), and a positive relationship was found between IL-12A expression and P&R (p = 0.020). Disease-free survival was affected by factors such as tumor size, extrathyroid extension, tumor stage (T stage), and IL-12A expression, with p values of 0.006, 0.048, 0.002, and 0.012, respectively. Multivariate Cox proportional-hazards analysis showed that tumor size ≥2 cm (hazard ratio [HR] = 4.041 [95% CI: 1.144-14.274], p = 0.031) and high IL-12A expression (HR = 4.027 [95% CI 1.014-15.994], p = 0.049) were independent predictors of prognosis of DTC patients. Conclusions: IL-12A is highly expressed in DTC and is associated with disease aggressiveness. In addition, IL-12A is an independent predictor of the outcome of DTC.

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PFOA, PFHxA and C6O4 differently modulate the expression of CXCL8 in normal thyroid cells and in thyroid cancer cell lines

Coperchini

Marco

Croce

et al. 2023

Environ Sci Pollut Res

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Serum interleukin measurement may help identify thyroid cancer patients with active disease

Cited by 22 publications

References 36 publications

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

High Expression of Interleukin-12A and Its Association with the Clinicopathology and Prognosis of Differentiated Thyroid Cancer

PFOA, PFHxA and C6O4 differently modulate the expression of CXCL8 in normal thyroid cells and in thyroid cancer cell lines

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