Serum ionized magnesium in post-traumatic headaches

Marcus, Joseph C.; Altura, Bella T.; Altura, Burton M.

doi:10.1067/mpd.2001.117287

Cited by 4 publications

(14 citation statements)

References 18 publications

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“…Whether physiologic concentrations of magnesium influence these receptors is not clear. Ionized magnesium is about one-half the concentration of ionized calcium in the blood of children [23]. On the other hand, because proximal tubular reabsorption of Mg 2þ is less than that for Ca 2þ , the magnesium concentration nearly doubles by the time the glomerular filtrate reaches the thick ascending loop, and this increase is thought to be sufficient to activate calcium receptors that regulate the reabsorption of both calcium and magnesium [22].…”

mentioning

confidence: 99%

Cisplatin nephrotoxicity affects magnesium and calcium metabolism

Goren

2003

Med. Pediatr. Oncol.

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Cisplatin is not directly toxic to bone, but cisplatin nephrotoxicity leading to magnesium wasting may affect magnesium and calcium metabolism, both of which contribute to bone integrity. The specificity of the magnesium lesion suggests that cisplatin may have an affinity for proteins that regulate magnesium absorption. Sulfhydryls such as amifostine can reduce the toxicity of cisplatin in adults, but current pediatric data do not indicate a role for sulfhydryl therapy to reduce cisplatin toxicity in children.

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mentioning

confidence: 99%

Cisplatin nephrotoxicity affects magnesium and calcium metabolism

Goren

2003

Med. Pediatr. Oncol.

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“…16 The role of inflammation in the pathophysiology of PTH is further supported by the findings of pain signaling molecules such as calcitonin gene-related peptide (CGRP) and nitric oxide synthase (NOs) which can activate the trigeminovascular system and trigger migraine headaches. 19,21 A mTBI mouse model study was conducted and demonstrated increased levels of these molecules and this increase was associated with trigeminal allodynia as well as photophobia in the acute phase. Increases in CGRP levels were noted at several levels along the trigeminal pathway, even at distant sites from the injury.…”

Section: Inflammationmentioning

confidence: 99%

“…It has been postulated that damage anywhere along the pain pathways can be a source of central pain. 14,21 Damage to spinothalamic or thalamocortical pathways would be most implicated and may occur even with mTBI. 15 Patients with PTH tend to have increased heat-pain thresholds which is in favor of a central origin.…”

Section: Peripheral Originmentioning

confidence: 99%

“…14 Loss or a decrease of descending pain inhibition and loss of opioidergic systems could also contribute to PTH, a mechanism also reported in TTH and migraine. 14,15,21 Further support for a central origin comes from imaging studies on mTBI patients with PTH migraines. Advanced magnetic resonance with diffusion-tensor imaging and proton spectroscopy is being increasingly studied as a means for the diagnosis of concussion or mTBI and PCS.…”

Section: Peripheral Originmentioning

confidence: 99%

“…Furthermore, all severities of TBI are often grouped together when discussing PTH and its pathophysiology, although clinical experience and several reports indicate that the mTBI population suffer from more PTH than their moderate-to-severe counterparts. 1,11,12,15,16,[19][20][21][22][23][24] In the PCS, photophobia is often the second most common symptom after headache and it often accompanies and complicates the headache disorder. This sensitivity to light and visual stimuli, including television or computer screens, is a significant burden for patients.…”

Section: Introductionmentioning

confidence: 99%

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Narrative Review of the Pathophysiology of Headaches and Photosensitivity in Mild Traumatic Brain Injury and Concussion

Mares

Dagher

Harissi‐Dagher

2018

Can. J. Neurol. Sci.

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The most common symptom of post-concussive syndrome (PCS) is post-traumatic headache (PTH) accompanied by photophobia. Post-traumatic headache is currently categorized as a secondary headache disorder with a clinical phenotype described by its main features and resembling one of the primary headache disorders: tension, migraine, migraine-like cluster. Although PTH is often treated with medication used for primary headache disorders, the underlying mechanism for PTH has yet to be elucidated. The goal of this narrative literature review is to determine the current level of knowledge of these PTHs and photophobia in mild traumatic brain injury (mTBI) in order to guide further research and attempt to discover the underlying mechanism to both symptoms. The ultimate purpose is to better understand the pathophysiology of these symptoms in order to provide better and more targeted care to afflicted patients. A review of the literature was conducted using the databases CINAHL, EMBASE, PubMed. All papers were screened for sections on pathophysiology of PTH or photophobia in mTBI patients. Our paper summarizes current hypotheses. Although the exact pathophysiology of PTH and photophobia in mTBI remains to be determined, we highlight several interesting findings and avenues for future research, including central and peripheral explanations for PTH, neuroinflammation, cortical spreading depolarization and the role of glutamate excitotoxicity. We discuss the possible neuroanatomical pathways for photophobia and hypothesize a possible common pathophysiological basis between PTH and photophobia.

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Complementary drugs

Weydert¹

2021

Oxford Textbook of Pediatric Pain

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Research into the use of botanical agents, nutritional supplements, and diet to manage pain has increased owing to the interest and demand of patients and physicians. Pharmacological agents are typically used as first-line therapy for pain and symptom management; however, for some patients these agents may not work well in the long term or have side effects that are not tolerated. Other patients may prefer nonpharmacological therapies. Most clinicians are not trained or may not be comfortable recommending these complementary agents. It is the goal of this chapter to introduce to practitioners the evidence-based data that support the safety and efficacy of these complementary drugs.

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Serum ionized magnesium in post-traumatic headaches

Cited by 4 publications

References 18 publications

Cisplatin nephrotoxicity affects magnesium and calcium metabolism

Cisplatin nephrotoxicity affects magnesium and calcium metabolism

Narrative Review of the Pathophysiology of Headaches and Photosensitivity in Mild Traumatic Brain Injury and Concussion

Complementary drugs

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