Serum Irisin level is associated with fall risk, muscle strength, and cortical porosity in postmenopausal women

Liang, Hanting; Qi, Wei; Jiajue, Ruizhi; Chi, Yue; Liu, Wei; Wang, Ou; Li, Mei; Xing, Xiaoping; Yu, Wei; Jiang, Yan; Xia, Weibo

doi:10.3389/fendo.2023.1096950

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Furthermore, muscle metabolism is primarily regulated by Irisin, a pro-myogenic factor derived from the fibronectin type III domain-containing protein 5 (FNDC5), attributed to skeletal muscle hypertrophy and increased protein synthesis via the AKT/mTOR pathway [8]. Several studies have reported an association between low circulating Irisin levels and low muscle and bone mass; however, its relationship with fat and lean body mass remains uncertain [10,11]. These various signaling pathways ultimately exert autocrine, paracrine, and endocrine effects on bone and muscle.…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Bone, Muscle, and Inflammatory Markers and Their Associations with Muscle Performance Variables

Sharma Ghimire,

Eckart,

Al-Makhzoomy

et al. 2023

Sports

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The importance of various markers such as Sclerostin, Dickkopf-1 (DKK-1), Irisin, receptor activator of NF-kB ligand (RANKL), and Vitamin D have been well studied in bone metabolism. Additionally, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and Interleukin 6 (IL-6) have been shown to hinder muscle protein synthesis, leading to the loss of muscle and strength. However, a research gap exists in understanding their role in muscle function and physical activity. Therefore, this study aims to explore the serum levels of Sclerostin, DKK-1, Irisin, IL-6, RANKL, Vitamin D, and TNF-α and assess their relationships with upper- and lower-body strength in young adults. In this study, 38 college-aged students (18–23 years), males and females, participated and completed the protocols. The participants’ lower and upper body strength were assessed by the vertical jump test (Just Jump, Probotic, AL) with a Tendo FitroDyne (Tendo Sports Machines, Trencin, Slovak Republic) and handgrip (HG) dynamometry (Takei Scientific Instruments, Yashiroda, Japan), respectively. Fasting morning blood samples were analyzed for serum levels of biomarkers by ELISA. The results indicate significant sex differences in Sclerostin, DKK-1, Irisin, and Vitamin D levels (p < 0.05). Furthermore, a positive association was observed between Sclerostin, DKK-1, and Vitamin D, with lower body muscle performance variables (p < 0.05). Conversely, a significant negative correlation was observed between TNF-α and lower-body muscle performance variables (p < 0.05). The results suggest that these markers may have a distinct effect on muscle performance, underscoring the need for further investigation to elucidate the concept of muscle–bone crosstalk.

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Section: Introductionmentioning

confidence: 99%

Sex Differences in Bone, Muscle, and Inflammatory Markers and Their Associations with Muscle Performance Variables

Sharma Ghimire,

Eckart,

Al-Makhzoomy

et al. 2023

Sports

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Sex Differences in Bone, Muscle, and Inflammatory Markers and Their Associations with Muscle Performance Variables

Sharma Ghimire,

Eckart,

Al-Makhzoomy

et al. 2023

Preprint

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The importance of various markers such as sclerostin, Dickkopf-1 (DKK-1), Irisin, receptor activator of NF-kB ligand (RANKL), and Vitamin D have been well studied in bone metabolism. Additionally, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and Interleukine-6 (IL-6) have been identified to hinder muscle protein synthesis, leading to the loss of muscle and strength. However, a research gap exists in the understanding their role in muscle function and physical activity. Therefore, this study aims to explore the serum levels of sclerostin, DKK-1, irisin, IL-6, RANKL, Vitamin D, and TNF-α and assess their relationships with upper and lower body strength in young adults. In this study, 38 college-aged students 18-23 years participated and completed the protocols. The participants’ lower and upper body strength were assessed by the vertical jump test (Just Jump, Probotic, AL) with a Tendo FitroDyne (Tendo Sports Machines, Trencin, Slovak Republic) and handgrip (HG) dynamometry (Takei Scientific Instruments, Yashiroda, Japan), respectively. Fasting morning blood samples were analyzed for serum levels of the biomarkers by ELISA. The results indicate significant sex differences in sclerostin, DKK-1, irisin, and vitamin D levels (p<0.05). Furthermore, a positive association was observed between sclerostin, DKK-1, and vitamin D, with lower body muscle performance variables (p<0.05). Conversely, a significant negative correlation was observed between TNF-α and upper-body muscle performance variables (p<0.05). The results suggest that these markers may have a distinct effect on muscle performance, underscoring the need for further investigation to elucidate the concept of muscle-bone crosstalk.

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Irisin Protects Musculoskeletal Homeostasis via a Mitochondrial Quality Control Mechanism

Zhao,

Wu,

Zhu

et al. 2024

IJMS

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Irisin, a myokine derived from fibronectin type III domain-containing 5 (FNDC5), is increasingly recognized for its protective role in musculoskeletal health through the modulation of mitochondrial quality control. This review synthesizes the current understanding of irisin’s impact on mitochondrial biogenesis, dynamics, and autophagy in skeletal muscle, elucidating its capacity to bolster muscle strength, endurance, and resilience against oxidative-stress-induced muscle atrophy. The multifunctional nature of irisin extends to bone metabolism, where it promotes osteoblast proliferation and differentiation, offering a potential intervention for osteoporosis and other musculoskeletal disorders. Mitochondrial quality control is vital for cellular metabolism, particularly in energy-demanding tissues. Irisin’s influence on this process is highlighted, suggesting its integral role in maintaining cellular homeostasis. The review also touches upon the regulatory mechanisms of irisin secretion, predominantly induced by exercise, and its systemic effects as an endocrine factor. While the therapeutic potential of irisin is promising, the need for standardized measurement techniques and further elucidation of its mechanisms in humans is acknowledged. The collective findings underscore the burgeoning interest in irisin as a keystone in musculoskeletal health and a candidate for future therapeutic strategies.

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Serum Irisin level is associated with fall risk, muscle strength, and cortical porosity in postmenopausal women

Cited by 3 publications

References 37 publications

Sex Differences in Bone, Muscle, and Inflammatory Markers and Their Associations with Muscle Performance Variables

Sex Differences in Bone, Muscle, and Inflammatory Markers and Their Associations with Muscle Performance Variables

Sex Differences in Bone, Muscle, and Inflammatory Markers and Their Associations with Muscle Performance Variables

Irisin Protects Musculoskeletal Homeostasis via a Mitochondrial Quality Control Mechanism

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