Serum iron deficiency and 25-hydroxyvitamin D deficiency as an independent risk factor for osteoporosis in postmenopausal Arab women

Ghaleb, Afnan; Abdi, Saba; Yakout, Sobhy M.; Hussain, Syed Danish; Wani, Kaiser; Masoud, Mohammad S.; Alnaami, Abdullah M.; Al-Daghri, Nasser M.

doi:10.1016/j.jksus.2020.10.014

Cited by 3 publications

(4 citation statements)

References 38 publications

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“…There was a significant correlation between serum OC and iron levels in both male and female participants which is similar to other published data (Choksi et al, 2018;Ghaleb et al, 2021). It is thought that there is a close relationship between serum OC and iron.…”

Section: Discussionsupporting

confidence: 90%

“…In wrestling, iron is also an important factor when it comes to performance (Tayebi et al, 2017). Pathologically, iron deficiency causes several health problems, including anaemia, hyperlipidaemia, lipid peroxidation, and changes in the vitamin metabolism (Ghaleb et al, 2021). In a previous study, Katsumata et al (2006) fed mice an iron-free diet to determine the association between bone density and dietary iron.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Rapid Weight Loss following Iron Supplementation on Bone Mineral Density and Serum Osteocalcin Levels in University Wrestlers

Lee¹,

Sung

2022

Int J Appl Sports Sci

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This experiment is designed for bone health in wrestlers and martial arts athletes who lose weight with Rapid Weight Loss (RWL). To clarify the effect of iron intake on the relationship between weight loss and bone densityFor athletes using the RWL strategy, iron intake was observed for bone mineral density (BMD), serum osteocalcin (OC) level, and serum iron marker. This study was conducted on 23 wrestlers (13 males and 10 females). It was divided into the trial 1 (iron intake and weight loss) and the trial 2 (only weight loss). In addition, between the first and second experiments, a washout period was given for 3 weeks} in order to eliminate the medicinal effect. All measurements were performed in the same group. However, the OC levels were reduced following RWL. In case of the males, the intake group after weight loss demonstrated a significant increase in BMD (p<0.05). Correlation analysis of the data for the male group showed significant correlations between serum OC and iron contents (p<0.05), total BMD and TIBC(total iron binding capacity) (p<0.05), and transferrin and iron concentrations (p<0.05). In the female group, serum OC and iron (p<0.01), transferrin and TIBC(total iron binding capacity) (p<0.01) showed correlations. In addition, between serum OC and ferritin (p<0.05), total BMD and ferritin (p<0.05), TIBC and iron (p<0.05) were shown to have some degree of correlation in the global evaluations.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Effects of Rapid Weight Loss following Iron Supplementation on Bone Mineral Density and Serum Osteocalcin Levels in University Wrestlers

Lee¹,

Sung

2022

Int J Appl Sports Sci

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“…In this cross-sectional study, the clinical information of participants was taken from the Osteoporosis Registry Database of the Chair for Biomarkers for Chronic Diseases (CBCD), a collaborative project of King Saud University (KSU) and the Ministry of Health [25]. In brief, the osteoporosis registry database contains clinical information of all Saudi adults whose BMD was assessed in several tertiary hospitals in Riyadh [King Fahad Medical City (KFMC), King Khalid University Hospital (KKUH), and King Salman Hospital (KSH)] from 2013 to 2016 [26][27][28]. The investigators adhered to all applicable ethical standards for collecting, storing, and analyzing human samples.…”

Section: Methodsmentioning

confidence: 99%

The single point insulin sensitivity estimator (SPISE) is associated with bone health in Arab adults

Al-Daghri,

Wani,

Khattak

et al. 2024

Aging Clin Exp Res

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Background The Single Point Insulin Sensitivity Estimator (SPISE) index is a surrogate marker for insulin sensitivity. Given the emerging role of bone as an active endocrine organ, its associations with non-invasive measures of extra-skeletal functions such as insulin sensitivity warrant investigation. Aims This study aimed to explore the relationship between the SPISE index and Bone Mineral Density (BMD) in an adult population. Methods Data from a total of 1270 Arab adults (84% females, mean age 56.7 ± 8.1 years) from the Osteoporosis Registry Database of the Chair for Biomarkers of Chronic Diseases in King Saud University, Riyadh, Saudi Arabia was used in this study. T-scores and SPISE were calculated. Regression models were used to determine associations between SPISE and bone health indices. Results The low BMD group (N = 853; T-score <-1.0) had significantly higher SPISE values than those with normal BMD (N = 417; T-score − 1.0 and above) (4.6 ± 1.3 vs. 4.3 ± 1.2, p < 0.001). Multivariate linear regression, adjusted for covariates, confirmed a significant inverse association between SPISE and BMD for all participants (β=-0.22, p < 0.001), as well as both groups [normal BMD (β = -0.10, p = 0.02) and low BMD groups (β = -0.15, p < 0.001)]. SPISE, family history of T2DM, and history of fractures collectively account for 17% of the variances perceived in T-score for all participants (p < 0.001). Conclusions A significant inverse association between the SPISE index and BMD was observed in adults, suggesting a link between BMD and extra-skeletal health. Underlying mechanisms need to be investigated prospectively using BMD as secondary outcomes in lifestyle modification programs.

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“…In this cross-sectional study, a total of 189 Saudi postmenopausal women aged ≥50 years old (N = 80 healthy control, N = 109 with low BMD) were randomly selected from the existing osteoporosis registry of the Chair for Biomarkers of Chronic Diseases (CBCD) in King Saud University (KSU), Saudi Arabia. In brief, this registry is a capital-wide database involving more than 1500 participants from the outpatient clinics of King Fahd Medical City, King Salman Hospital, and King Saud University Medical City, Riyadh, Saudi Arabia, whose BMD measurements were assessed and recorded between 2013 and 2016 [ 27 , 28 ]. A generalized questionnaire was used to collect participants’ history (age, medical history, disease status, etc.).…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Metabolites and Sex Steroid Indices in Postmenopausal Women with and without Low Bone Mass

et al. 2021

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While the independent roles of vitamin D and sex hormones in skeletal health are well established, the associations of vitamin D and its metabolites to sex hormones and their indices are less investigated. In this observational study, clinical information of 189 Saudi postmenopausal women aged ≥50 years old [N = 80 with normal bone mineral density (BMD), aged 53.3 ± 7.7 years with body mass index (BMI)= 34.1kg/m2 ± 5.8, and N = 109 with low BMD (T-score −1.0 to −2.5), aged 57.0 ± 8.2 years, BMI = 32.4kg/m2 ± 6.2] was extracted from an existing capital-wide osteoporosis registry in Riyadh, Saudi Arabia. Data included were BMD scores, serum total 25(OH)D, sex hormones, and bone turnover markers which were measured using commercially available assays. Age- and BMI-adjusted comparisons revealed significantly higher parathyroid hormone (PTH) levels as well as significantly lower testosterone and bioavailable testosterone in the low BMD group than the normal BMD group (p-values 0.04, 0.02, and 0.03, respectively). Stepwise linear regression showed that circulating testosterone levels accounted for 9.7% and 8.9% of the variances perceived in bioavailable 25(OH)D and free 25(OH)D, respectively (p < 0.01), independent of other sex hormones, sex hormone indices, and bone turnover markers. Our study suggests that androgens are significantly associated with non-conventional vitamin D metabolites and these associations may have clinical relevance in assessing risk for low BMD and osteoporosis in Arab postmenopausal women.

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Serum iron deficiency and 25-hydroxyvitamin D deficiency as an independent risk factor for osteoporosis in postmenopausal Arab women

Cited by 3 publications

References 38 publications

Effects of Rapid Weight Loss following Iron Supplementation on Bone Mineral Density and Serum Osteocalcin Levels in University Wrestlers

Effects of Rapid Weight Loss following Iron Supplementation on Bone Mineral Density and Serum Osteocalcin Levels in University Wrestlers

The single point insulin sensitivity estimator (SPISE) is associated with bone health in Arab adults

Vitamin D Metabolites and Sex Steroid Indices in Postmenopausal Women with and without Low Bone Mass

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