Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis

Pişkin, Şenol; Sayan, Cemile Dayangan; Durukan, N; Şenol, Mustafa

doi:10.1046/j.1468-3083.2002.00369.x

Cited by 97 publications

(84 citation statements)

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“…Vitamin C inhibits division and growth of cell through the production of hydrogen peroxide, which damages the cells probably through an unidentified free radical(s) generation (Maramag et al 1997). It has been shown that Fe, Ca, and vitamins B12 and C were lower (Ogura et al 2001;Piskin et al 2002) and supplementation with vitamin B12 led to marked improvements in patients suffering from RAU initially deficient in vitamin B12.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Salivary and Serum Antioxidant Vitamins and Lipid Peroxidation in Patients with Recurrent Aphthous Ulceration

Saral

Coşkun

Öztürk

et al. 2005

Tohoku J. Exp. Med.

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Recurrent aphthous ulceration (RAU) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae. Although the exact cause of RAU is not known, local trauma, microorganisms, nutritional deficiencies, hormonal changes, genetics, and immunological factors have been suggested to contribute to its pathogenesis. The aim of this study was to assess the level of lipid peroxidation and status of antioxidant vitamins in patients with RAU. Thirty patients with RAU and 20 healthy controls were recruited. Vitamins A, E, and C and malondialdehyde (MDA) levels were measured in both serum and saliva of patients with RAU and control subjects by high performance liquid chromatography. Levels of vitamins A, E and C in both fluids were significantly lower (p < 0.05 for vitamins A and E, and p < 0.005 for vitamin C, respectively) in patients with RAU than in healthy control subjects. Conversely, the levels of MDA in serum and saliva were significantly higher (p < 0.005) in patients with RAU than in the control group. Furthermore, strong and highly significant correlation was found between serum and salivary levels of vitamins A, E and C, and MDA in patients with RAU (r 0.90, p < 0.0001). The present study demonstrates that the serum and saliva levels of selected antioxidant vitamins are lower, while the degree of lipid peroxidation, as judged by the MDA levels, is higher in patients with RAU than in the control subjects. This is the first to measure specific antioxidant levels in both saliva and blood in the same patients, and indicates that the non-enzymatic anti-oxidant ability is impaired in patients with RAU. recurrent aphthous ulceration; antioxidant vitamins; MDA; nonenzymatic defense system; saliva

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Section: Discussionmentioning

confidence: 99%

Assessment of Salivary and Serum Antioxidant Vitamins and Lipid Peroxidation in Patients with Recurrent Aphthous Ulceration

Saral

Coşkun

Öztürk

et al. 2005

Tohoku J. Exp. Med.

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“…In the research conducted by Piskin et al only the serum level of vitamin B12 was statistically lower in patients with aphthous. It was concluded that vitamin B12 deficiency might be involved in etiology of recurrent aphthous stomatitis (12). The results of the research conducted by Kozlak showed that patients with recurrent aphthous stomatitis had an inadequate daily intake of vitamin B12 and folate compared to the general population.…”

Section: Discussionmentioning

confidence: 99%

“…In the current research, as recovery was observed in both interventional groups, one can consider the important role of alternative and systemic treatments in the improvement of aphthous lesions. Many studies have reported cases of nutritional deficiencies in patients with aphthous (12,15,16).…”

Section: Discussionmentioning

confidence: 99%

Comparing the Effect of Injectable Vitamin B With Conventional Oral Treatment on Aphthous Stomatitis

et al. 2017

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Background: Recurrent aphthous stomatitis (RAS) is a common condition with recurrent ulcerations limited to the oral mucosa. Different predisposing factors have been proposed, including iron, vitamin B12, and folic acid deficiencies. The aim of this study was to evaluate the effect of injectable vitamin B in comparison with a form of oral therapy on recurrent Aphthous stomatitis. Methods: This randomized clinical trial was performed on 60 patients with RAS, during years 2015 and 2017. All patients were at least 18 years of age without systemic disease associated with RAS. All the study population had a minor type of Aphthous ulcers with two months of maximum recurrence intervals during the last year. Additionally, all patients benefited from a checklist, including demographic data and relapse intervals, and a number of lesions were completed before the start of the study. Also, blood tests were performed to evaluate a complete counting of blood cells, and levels of ferritin, vitamin B12, and folic acid. Next, patients were randomly divided to two groups comprised of those that received eight weeks of injectable vitamin B (a combination of B1, B6, and B12) and those on eight weeks of chewable tablets (a combination of iron, folic acid, vitamin B complex, and vitamin C). Finally, all patients were monitored for 10 months. Results: There were no statistically significant differences between the two groups in terms of deficiencies in ferritin, vitamin B12, and folic acid (P > 0.05). In the injectable form of treatment, the efficacy was excellent in 14, moderate in 12, and low in four patients while in the oral form, the efficacy was moderate in nine and low in 12 patients. It is important to consider that there was no response to treatment in nine patients. Conclusions:The injectable form of Vitamins B that contains a high dose of vitamin B had better efficacy than the oral form. Accordingly, it can be concluded that the injectable form of vitamin B might be an effective treatment as it is considered a simple, inexpensive, and low-risk treatment for patients with RAS, regardless of ferritin, vitamin B12, and folic acid levels.

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“…These ulcerations may be indicative of underlying systemic diseases ranging from vitamin deficiency to autoimmunity [3]. There are several studies investigating the role of genetics, stress, hematinic deficiencies, vitamin deficiencies, trauma, microbial agents and autoimmunity in the literature [4][5][6][7][8].…”

Section: Recurrent Aphthous Stomatitis(ras) Is a Disease Which Presentsmentioning

confidence: 99%

Relationship of Recurrent Aphthous Stomatitis with Nutritional Habits

Özler¹

2015

Ann Clin Anal Med

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ÖzetAmaç: Bu çalışmada geriatrik hasta grubunda reküren aftöz stomatit(RAS) sıklığı ve oral aftların aile öyküsü, boy, kilo, antibiyotik kullanımı, diş fırçala-ma ve beslenme alışkanlıkları ile ilişkisi araştırıldı. Gereç ve Yöntem: Altmış beş yaş üstü hastalar çalışmaya dahil edildi. Değerlendirme öncesi olgulara oral aftöz ülser tanımı yapıldı ve fotoğraflardan oluşan bir görsel bilgilendime formu sunuldu. Hastaların yaşı,cinsiyeti,boyu ve kilosu not edildi. Ardından RAS öyküsü sorgulandı ve oral aft öyküsü olanların ülser sıklığı, ülser tipi, ül-ser yerleşimi, ülserin neden olduğu subjektif semptom, aile öyküsü, antibiyotik kullanım sıklığı, diş fırçalama alışkanlığı ve beslenme alışkanlıkları bir anket ile değerlendirildi. Bulgular: Seksen hasta çalışmayı tamamladı. Olguların %31, 5' i reküren oral ülser tarifledi. Olguların %44'ü tarafından tanımla-nan ağrı en sık görülen subjektif semptom idi. Olguların % 15'inde aile öyküsü mevcuttu. Antibiyotik kullanım sıklığı ile RAS öyküsü arasında korelasyon saptanmadı. Aynı zamanda, diş fırçalama alışkanlığı ile RAS arasında da korelasyon saptanmadı. RAS' lı grup çay ve asitli içecekleri daha sık tüketirken,süt ve süt ürünlerini, cevizi, ekmek ve diğer tahılları daha nadir tüketmekteydi. Tartışma: Beslenme alışkanlıkları reküren aftöz ülser oluşumunda rol oynayabilir.Bu nedenle riskli besinlerin alımının kesilmesi ve koruyucu besinlerin eklenmesi tedavi periyodunun ilk adımı olabilir. Anahtar KelimelerGeriatrik Hastalar; Reküren Aftöz Stomatit(RAS); Beslenme Abstract Aim: In this study we investigated the frequency and relationship of recurrent aphthous stomatitis(RAS) with family history, personal variables such as weight, heigt, antibiotic usage, teeth brush and nutritional habits in geriatric patients. Material and Method: The patients over 65 years old were included in the study. Before examination, the definition of recurrent oral aphthous ulcers and a visual informatory form including photographs were presented to the subjects. The age, sex, height, weight of the subjects were noted on a chart. Then the history of recurrent oral aphthous ulcerations were asked and if present the frequency of the ulcers, the type of the ulcers, the localization of the ulcers, the subjective symptome of the ulcers, familial history for the ulcers, frequency of antibiotic usage, teeth brush habits and nutritional habits were examined by a questionnaire. Results: Eighty subjects completed the study. 31.25% of subjects declared recurrent oral ulcer history. Pain was the leading subjective symptome declared by 44% of the subjects. 15% of the subjects had a family history for recurrent oral ulcers. There was no correlation between frequency of antibiotic usage and history of RAS. Also, there was no correlation between teeth brush habits and history of RAS. The RAS group consumed tea and fizzdrinks more frequently whereas they consumed milk and milk products, walnut, bread and other grains more rarely. Discussion: Nutritional habits may have a role on ocurrence of reccurrent oral apht...

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Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis

Abstract: We concluded that vitamin B 12 deficiency may be an aetiological factor in recurrent aphthous stomatitis.

Cited by 97 publications

References 4 publications

Assessment of Salivary and Serum Antioxidant Vitamins and Lipid Peroxidation in Patients with Recurrent Aphthous Ulceration

Assessment of Salivary and Serum Antioxidant Vitamins and Lipid Peroxidation in Patients with Recurrent Aphthous Ulceration

Comparing the Effect of Injectable Vitamin B With Conventional Oral Treatment on Aphthous Stomatitis

Relationship of Recurrent Aphthous Stomatitis with Nutritional Habits

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