Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

Deng, Yueling; Jiang, Tao; Li, Jinhao; Yu, Pingping; Mei, Ying; Li, Maojun; Qi, Xiaoya; Liu, Fuyao

doi:10.1016/j.isci.2023.107774

Cited by 3 publications

(4 citation statements)

References 42 publications

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“…For more details on validation data sets, please refer to Deng et al. 1 CRITICAL: In this phase, various organelles and their corresponding factors, pivotal in the early stages of ferroptosis, are systematically assessed. Ultimately, we prioritize the selection of well-established and commonly employed laboratory test indicators, while avoiding the inclusion of novel or uncommon examination markers.…”

Section: Step-by-step Methods Detailsmentioning

confidence: 99%

“… Analyze the latest progress in ferroptosis research. 1 , 3 , 4 , 5 , 6 , 10 , 11 , 12 , 13 , 14 , 15 , 16 Note: By conducting a comprehensive review of contemporary literature available online, we systematically examined the recent advancements in ferroptosis—a current focal point in research. Upon scrutinizing pertinent studies from the last five years, it became apparent that ferroptosis has been substantiated in numerous chronic diseases.…”

Section: Before You Beginmentioning

confidence: 99%

“…Analyze the latest progress in ferroptosis research. 1 , 3 , 4 , 5 , 6 , 10 , 11 , 12 , 13 , 14 , 15 , 16 …”

Section: Before You Beginmentioning

confidence: 99%

“…For complete details on the use and execution of this protocol, please refer to Yueling Deng et al. 1 …”

mentioning

confidence: 99%

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Protocol for deep mining the correlation between acute pancreatitis and ferroptosis using the MIMIC-III database and STATA software

Deng,

Jiang,

Zhang

et al. 2024

STAR Protocols

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Section: Step-by-step Methods Detailsmentioning

confidence: 99%

Section: Before You Beginmentioning

confidence: 99%

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Protocol for deep mining the correlation between acute pancreatitis and ferroptosis using the MIMIC-III database and STATA software

Deng,

Jiang,

Zhang

et al. 2024

STAR Protocols

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Bioinformatics Identification and Validation of Ferroptosis-Related Key Genes and Therapeutic Compounds in Septic Lung Injury

Li,

Gan,

et al. 2024

JIR

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Background Septic lung injury (SLI) is a severe condition with high mortality, and ferroptosis, a form of programmed cell death, is implicated in its pathogenesis. However, the explicit mechanisms underlying this condition remain unclear. This study aimed to elucidate and validate key ferroptosis-related genes involved in the pathogenesis of SLI through bioinformatics analysis and experimental validation. Methods Microarray data related to SLI from the GSE130936 dataset were downloaded from the Gene Expression Omnibus (GEO) database. These data were then intersected with the FerrDb database to obtain ferroptosis-related differentially expressed genes (DEGs). Protein-protein interaction (PPI) networks and functional enrichment analysis were employed to identify key ferroptosis-related DEGs. The Connectivity Map (c-MAP) tool was used to search for potential compounds or drugs that may inhibit ferroptosis-related DEGs. The transcriptional levels of the key genes and potential therapeutic compounds were verified in an LPS-induced mouse model of lung injury. The expression of these key genes was further verified using the GSE60088 and GSE137342 datasets. Results 38 ferroptosis-related DEGs were identified between the septic and control mice. PPI network analysis revealed four modules, the most significant of which included eight ferroptosis-related DEGs. Functional enrichment analysis showed that these genes were enriched in the HIF-1 signaling pathway, including IL-6 (Interleukin-6), TIMP1 (Tissue Inhibitor of Metalloproteinase 1), HIF-1α (Hypoxia-Inducible Factor-1α), and HMOX1 (Heme Oxygenase-1). Phloretin, a natural compound, was identified as a potential inhibitor of these genes. Treatment with phloretin significantly reduced the expression of these genes ( p < 0.05), mitigated lung injury, improved inflammatory profiles by approximately 50%, and ferroptosis profiles by nearly 30% in the SLI models. Conclusion This study elucidates the significant role of ferroptosis in SLI and identifies phloretin as a potential therapeutic agent. However, further research, particularly involving human clinical trials, is necessary to validate these findings for clinical use.

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The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment

Lyu,

Kong,

Chen

et al. 2024

IJMS

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Pancreatic cancer remains one of the most lethal forms of cancer. Currently, there is a lack of effective drug treatments for pancreatic cancer. However, as a newly discovered form of non-apoptotic cell death, ferroptosis has garnered increasing attention in relation to pancreatic cancer. Understanding the role of ferroptosis in the tumorigenesis and treatment of pancreatic cancer may enable more effective clinical trials and treatments for pancreatic cancer and may minimize side effects or restrict the emergence of drug resistance. In this review, we summarize the current knowledge regarding the process and underlying mechanisms of ferroptosis, as well as its dual role in both promoting tumorigenesis and facilitating treatment strategies for pancreatic cancer. Additionally, how ferroptosis is implicated in the development of pancreatitis and insulin resistance, indicating that ferroptosis may play an important role in the risk of pancreatitis- and insulin-resistance-related pancreatic cancers, is also addressed.

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Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

Cited by 3 publications

References 42 publications

Protocol for deep mining the correlation between acute pancreatitis and ferroptosis using the MIMIC-III database and STATA software

Protocol for deep mining the correlation between acute pancreatitis and ferroptosis using the MIMIC-III database and STATA software

Bioinformatics Identification and Validation of Ferroptosis-Related Key Genes and Therapeutic Compounds in Septic Lung Injury

The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment

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