Serum iron levels are negatively correlated with serum triglycerides levels in female university students

He, Lianping; Zhang, Yanman; Ru, Dongqing; Xue, Baohong; Wen, Shuang; Zhou, Hong

doi:10.21037/apm.2020.03.02

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…1 D). This observation is in agreement with the inferences drawn from a cross-sectional study on 290 individuals wherein He et al 5 found a negative correlation between dyslipidemia (high triglyceride and low high-density lipoprotein cholesterol levels) and serum iron. The absence of excess iron in hypercholesterolemia indicates the prognostic application of excess iron as a marker for the progression of hypercholesterolemia to MetS.…”

Section: Comparison Of Ferroptosis Molecular Mediators In Mets T2d An...supporting

confidence: 91%

Ferroptosis mediators vary in metabolic syndrome, type-2 diabetes, and hypercholesterolemia: A meta-analysis report

Kundu

Das

et al. 2024

Genes & Diseases

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Section: Comparison Of Ferroptosis Molecular Mediators In Mets T2d An...supporting

confidence: 91%

Ferroptosis mediators vary in metabolic syndrome, type-2 diabetes, and hypercholesterolemia: A meta-analysis report

Kundu

Das

et al. 2024

Genes & Diseases

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“…This study also has several limitations: To begin, our study included a smaller sample size. Second, it is reported that serum iron level is negatively correlated with serum triglyceride, 33 and free fatty acids are associated with SLE. 34 Therefore, whether other trace elements are associated with SLE activity and prognosis should be explored further.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Total Serum Calcium Level Is Negatively Correlated With Systemic Lupus Erythematosus Activity

Sha

Rui²,

Dong

et al. 2020

Dose-Response

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease and hypocomplementemia signifies disease activity. Several studies have shown that calcium may help maintain optimum function of immune system and metabolism in SLE. The aim of our study was to analyze the relationship between total serum calcium level and SLE activity. A total of 66 patients with SLE and 214 healthy controls were included in this study. Our results showed lower serum levels of calcium ( P < .001), complement C3 ( P < .001), complement C4 ( P < .001), and albumin ( P < .001) in patients with SLE. A negative correlation was found between serum calcium level and systemic lupus erythematosus disease activity index (SLEDAI) rating ( r = −0.394, P = .001). Additionally, serum level of calcium was positively correlated with serum complement C3 level ( r = 0.366, P = .003) in patients with SLE, while no such correlation was found between serum calcium level and complement C4 ( r = −0.190, P = .126). Likewise, patients with SLE with normal serum calcium level showed higher complement C3 level ( P < .01) than that of patients with low serum calcium level. Overall, the results displayed that patients with SLE have lower serum calcium level compared to healthy controls, and the serum calcium level is positively correlated with SLEDAI rating and serum complement C3 level in patients with SLE. In conclusion, the total serum calcium level is negatively correlated with SLE disease activity.

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“…Similar to our results, in a cross-sectional study conducted on 7,540 adults, after adjusting for covariates, the levels of LDL-C were positively related to iron levels [ 64 ]. The results of another cross-sectional study showed that serum iron concentration was positively associated with HDL-C, LDL-C, and TC, but was inversely associated with TG in female students [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

The association between lipid profile, oxidized LDL and the components of metabolic syndrome with serum mineral status and kidney function in individuals with obesity

Ardekani,

Nava,

Zaman

et al. 2023

BMC Res Notes

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Background Metabolic syndrome (MetS) is presented with a cluster of cardio-metabolic risk factors with widespread prevalence. In the present case-control study, we aimed to examine the relationship between several minerals and renal function tests with the components of MetS in individuals with obesity. Methods This study included 127 individuals with obesity of both gender with or without MetS as the case and control, respectively. MetS was characterized based on the Adult Treatment Panel III (ATP III) criteria. Anthropometric variables and blood pressure were recorded. Mineral status including serum magnesium, copper, calcium, phosphorous, and iron were measured using standard colorimetric methods. Also, the serum lipid levels, concentrations of oxidized low-density lipoprotein (Ox-LDL), and renal function tests, including total protein, albumin, urea, creatinine, and uric acid were evaluated using commercial enzyme-linked immunosorbent assay (ELISA) kits. Results According to our results, individuals with obesity and MetS had higher levels of waist circumference (WC) and diastolic blood pressure (P < 0.05) compared to individuals with obesity and without MetS. Moreover, individuals with obesity and MetS had higher levels of serum total cholesterol (TC), triglyceride (TG), insulin, and iron (P < 0.05). In individuals with obesity and MetS, iron and albumin showed a positive relationship with LDL cholesterol and TG concentrations, respectively (P < 0.05 for all of them). Also, there was a positive association between serum magnesium and Ox- LDL in individuals with obesity with MetS. While, in individuals with obesity and without MetS, only a positive association between urea and uric acid with WC was observed (P < 0.05). Conclusion Our results suggest that disturbed serum lipids in obesity-metabolic syndrome is associated with homeostatic changes in the level of minerals or proteins that are involved in their metabolism. Although, further studies are needed to better explain and clarify the underlying mechanism of observed relationships.

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Serum iron levels are negatively correlated with serum triglycerides levels in female university students

Cited by 8 publications

References 9 publications

Ferroptosis mediators vary in metabolic syndrome, type-2 diabetes, and hypercholesterolemia: A meta-analysis report

Ferroptosis mediators vary in metabolic syndrome, type-2 diabetes, and hypercholesterolemia: A meta-analysis report

RETRACTED: Total Serum Calcium Level Is Negatively Correlated With Systemic Lupus Erythematosus Activity

The association between lipid profile, oxidized LDL and the components of metabolic syndrome with serum mineral status and kidney function in individuals with obesity

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