Serum Iron profile in Female patients of Melasma-A case control study

Qazi, Iram; Dogra, Naina; Dogra, Devraj

doi:10.21276/apjhs.2017.4.2.24

Cited by 6 publications

(9 citation statements)

References 7 publications

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“…In the present study, all variables were tested for association with MASI, but the results showed no significance. On the contrary to these results, Qazi et al stated a positive correlation between MASI score and iron profile [17], which could be also due to the lower mean serum iron in the study by Qazi et al, while only reduced iron storage was detected in the patients of the present study.…”

Section: Discussioncontrasting

confidence: 99%

“…In the present study, the mean age of the groups had significant differences, which could also be attributed to different iron profile, so we adjusted the analysis regarding the age difference. The study by Qazi et al (2017), comparing 70 nonpregnant women with melasma and the control group, showed a lower mean serum iron and ferritin levels, beside a higher TIBC in the case group [17]. These results showed a higher frequency of anemia and lower iron storage in women with melasma, which was consistent to the results of the present study, although the Hb and TIBC levels did not differ between the groups in our study and lower iron storage, was indicated by the lower mean serum iron and higher frequency of below normal range ferritin level.…”

Section: Discussionmentioning

confidence: 99%

“…The sample size was calculated at 51 in each group based on the mean serum iron level of the study by Qazi and colleagues [17], considering type I and II error of 0.05 and 0.20, respectively. Accordingly, a total of 102 women were investigated in two groups: 51 patients in the case group and 51 patients in the control group.…”

Section: Study Samplementioning

confidence: 99%

“…Iron deficiency anemia is a public health problem with the highest prevalence in women of reproductive age [15] the same population susceptible for melasma. Evidence has suggested that hyper pigmentation can occur as a result of iron deficiency anemia and patients with melasma have been reported to have a lower serum levels of hemoglobin (Hb), iron, ferritin and total iron binding capacity (TIBC) [14,16,17]. Hence, these studies had several limitations, such as limited sample size and not controlling the effect of confounders, like endocrine disorders and using medications like oral contraceptives, which could affect the results.…”

Section: Introductionmentioning

confidence: 99%

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The association between melasma and iron profile: a case-control study

Goodarzi¹,

Behrangi²,

Sadeghzadeh‐Bazargan³

et al. 2020

Russ Open Med J

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Background — Melasma is a chronic acquired localized hypermelanosis, causing aesthetic problem for women and impairing their quality of life. Evidence has suggested that hyperpigmentation can occur as a result of iron deficiency anemia and vitamin B12 deficiency. Aim — We aimed to evaluate the serum parameters of iron profile in melasma patients. Material and Methods — This case-control study investigated 51 adult non pregnant women with melasma, compared with 51 controls, from patients referred to the Hospital, Tehran, Iran, 2017–2018. Melasma was diagnosed clinically according to the melasma area and severity index (MASI) score was calculated and recorded by the physician. The groups were compared in terms of vitamin B12, folate, serum iron, hemoglobin (Hb), mean corpuscular volume (MCV), total iron binding capacity (TIBC), and ferritin. Results — The mean and standard deviation of the women’s age was 36.89±8.88 years, significantly higher in the group of patients with melasma. Comparing the serum parameters between the groups indicated no statistically significant difference in terms of mean levels of ferritin, Hb, MCV, iron, vitamin B12, TIBC, and folate. The women in melasma group had a higher frequency in below normal range of ferritin and serum iron compared to the control group. None of the serum parameters were correlated with MASI. Conclusion — The higher frequency of below normal range of ferritin and serum iron levels in women with melasma compared to the control group showed a possible association between these serum parameters and melasma.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Samplementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The association between melasma and iron profile: a case-control study

Goodarzi¹,

Behrangi²,

Sadeghzadeh‐Bazargan³

et al. 2020

Russ Open Med J

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“…21 Iram Qazi et al also showed patients with melasma had low body Iron stores compared to the control population indicating a possible role of iron deficiency in the etiopathogenesis of melisma. 22 In our study, we found that about 80% of women and 20% of men have melasma. Most studies conducted in India showed almost similar results.…”

Section: Discussionmentioning

confidence: 50%

A cross-sectional study of thyroid profile, Anti-TPO and iron levels with uric acid of melasma cases in tertiary hospital, Bhopal

Yadav

Dutta²,

Thambrakar³

2022

IJCBR

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Melasma, also called ‘chloasma’, is a common skin condition of adults in which light to dark brown or grayish pigmentation develops, mainly on the face. Although it can affect both genders and any race, it is more common in women. Melasma is an acquired pigmentary disorder described as symmetrical blotchy or splotchy hyperpigmented macules and patches. The aim of this study was to investigate thyroid profile with anti TPO and iron, uric acid level, in male and female patients. It is a cross-sectional observational study done on 76 females and 25 male who were diagnosed with melasma and thyroid profile with anti TPO, serum iron and uric acid levels were measured. In our study females were more affected then males. In females Mean ± SD value of serum TSH (5.1±2.51) and anti-TPO (11.2±3.1) levels were increased when compared to males(4.9±2.54) and (9.2±1.9). Serum iron value was low in females (83.7±30) than males (90±29). All biochemical parameter were not significant but anti TPO and FT3 showed significant (P<0.001) in female with compared to male. Serum uric acid (3.56±0.77) and serum iron (83.7±30) Mean± SD value was low in melasma females than males which is not significant. Females Mean±SD value of T3 (1.30±0.62) and T4(6.8±1.9), FT4 (1.2±0.44) were non significance showed than compared to males and not significant to males T3 (1.33±0.66) and T4(7.1±1.6), FT4 (1.3±0.67) respectively. Melasma is more severe in females than males. Thyroid profile is not the accurate parameter but anti TPO, and iron level are predictive marker of melasma.

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Kadar feritin yang rendah merupakan faktor risiko melasma pada wanita

Stephanie

Rusyati

Karna³

et al. 2022

Intisari Sains Medis

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Introduction: Melasma is an acquired pigmentation disorder characterized by symmetrical hyperpigmented patches, most commonly seen on the face. Melasma and iron deficiency are most common in women of reproductive age. Iron deficiency causes a decrease in ferritin levels, which are iron stores in the body. The mechanism of iron deficiency causing melasma is thought to be due to cell hypoxia in the tissue involving mediators that increase melanogenesis. This study aims to prove that the mean ferritin level is lower in melasma than without melasma and that low ferritin levels are a risk factor for melasma in women. Methods: A case-control research included 28 participants with melasma and 28 without melasma who visited the dermatovenereology department of Prof. Dr. I.G.N.G Ngoerah Hospital, medical cosmetic division, in May-July 2022. The two groups will compare ferritin mean and ferritin risk factor analysis on the incidence of melasma. Data were tabulated and analyzed using SPSS 26. Results: The mean age in the melasma group was 40.64±3.39 years old, and the group without melasma was 37.64±3.50 years old (p=0.75). Of the 28 melasma subjects, there were more subjects with low ferritin levels (60.7%) than the group without melasma (32.1%). From the results of the Mann-Whitney test, the mean ferritin level in the melasma group (36.32±31.05) was significantly lower than in the non-melasma group (58.26±5.39); p=0.006. From the results of the Chi-Square test, it was found that low ferritin levels had a risk of 3.2 times the occurrence of melasma [OR (95% CI) = 3.2 (1.098-9.776), p=0.032]. Conclusion: The mean ferritin level in women with melasma is lower than in women without melasma, and low ferritin levels are a risk factor for melasma. Latar Belakang: Melasma merupakan kelainan pigmentasi didapat yang ditandai dengan adanya bercak hiperpigmentasi simetris, paling sering terlihat pada wajah. Melasma dan defisiensi besi paling sering dijumpai pada wanita usia reproduktif. Defisiensi besi menyebabkan turunnya kadar feritin yang merupakan cadangan besi dalam tubuh. Mekanisme defisiensi zat besi menyebabkan melasma diduga akibat hipoksia sel di dalam jaringan melibatkan mediator yang meningkatkan melanogenesis. Studi ini bertujuan untuk membuktikan rerata kadar feritin lebih rendah pada melasma dibandingkan tanpa melasma serta membuktikan kadar feritin yang rendah merupakan faktor risiko melasma pada wanita. Metode: Studi case-control yang melibatkan 28 subjek dengan melasma dan 28 subjek tanpa melasma yang berobat ke poliklinik kulit dan kelamin RSUP Prof. Dr. I.G.N.G Ngoerah divisi kosmetik medik periode Mei-Juli 2022. Kedua kelompok akan dibandingkan rerata feritin dan analisis faktor risiko feritin terhadap kejadian melasma. Data ditabulasi dan dianalisis dengan menggunakan SPSS 26. Hasil: Rerata usia pada kelompok melasma 40.64±3,39 tahun dan kelompok tanpa melasma 37,64±3,50 tahun (p=0,75). Dari 28 subjek melasma, didapatkan lebih banyak subjek dengan kadar feritin rendah (60,7%) dibandingkan kelompok tanpa melasma (32,1%). Dari hasil uji Mann-Whitney didapatkan rerata kadar feritin pada kelompok melasma (36,32±31,05) lebih rendah secara signifikan dibandingkan pada kelompok bukan melasma (58,26±5,39); p=0,006. Dari hasil uji Chi-Square didapatkan kadar feritin yang rendah memiliki risiko sebesar 3,2 kali terjadinya melasma [OR (IK 95%) =3,2 (1,098-9,776), p=0,032]. Simpulan: rerata kadar feritin pada wanita dengan melasma lebih rendah dibandingkan wanita tanpa melasma dan kadar feritin yang rendah merupakan faktor risiko melasma.

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Serum Iron profile in Female patients of Melasma-A case control study

Cited by 6 publications

References 7 publications

The association between melasma and iron profile: a case-control study

The association between melasma and iron profile: a case-control study

A cross-sectional study of thyroid profile, Anti-TPO and iron levels with uric acid of melasma cases in tertiary hospital, Bhopal

Kadar feritin yang rendah merupakan faktor risiko melasma pada wanita

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