Serum Ischemia Modified Albumin Levels in Diabetic Retinopathy

Abstract

Background.
 This study was planned determine and compare the levels of ischemia modified albumin in controls and diabetic patients with and without retinopathy.
 Materials and Methods: Diabetic Clinic of Lahore General Hospital was selected the conduction of the study in collaboration with an opthalmologists from September 2014-May 2015. 60 subjects of either sex were chosen and were separated into 3 groups with 20 subjects in each group. Group 1 was of normal healthy controls, group 2 of diabetics without retinopathy and group 3 of diabetics with retinopathy. Diabetic retinopathy was diagnosed by an ophthalmologist by an indirect method using a 90D lens on slit lamp examination, and IMA levels were determined by rapid calorimetric method.
 Results: The median (IQR) of serum levels of IMA in three groups were 0.51(0.43-0.54) in group I, 0.59(0.53-0.61) in group II and 0.63(0.59-0.71) ABSU .A significantly higher IMA levels in diabetics with retinopathy were seen as compared to diabetic without retinopathy and control with a p value of 0.00 respectively.
 Conclusion: Our study concludes that serum IMA levels raise as the diabetes progresses in its complications.