Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: A cross-sectional study

Ishitobi, Minori; Hosaka, Toshio; Morita, Naru; Kondo, Ken; Murashima, Toshitaka; Kitahara, Atsuko; Takahashi, Kazuto; Sumitani, Yoshikazu; Tanaka, Toshiaki; Yokoyama, Toshihiko; Kondo, Takuma; Ishida, Hideyuki

doi:10.1016/j.diabres.2019.01.028

Cited by 11 publications

(12 citation statements)

References 45 publications

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“…It is known that the role of the liver is one of the leading among individual organs and tissues, in maintaining the acid-base balance of the blood. Liver cells utilize lactate and, when the lactate dehydrogenase reaction is involved, transform it into pyruvate, which is then involved in gluconeogenesis [19]. In our opinion, the increase in lactate levels is a consequence of disruption of metabolic processes in cells, transport processes in the plasma membranes of hepatocytes and increased permeability of plasma membranes.…”

Section: Discussionmentioning

confidence: 94%

Study of hepatoprotective effect of bearberry leaves extract under insulin resistance in rats

Mazen¹,

Kravchenko²,

Krasilnikova³

2021

Eureka: HS

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The aim of our study was to evaluate the antidiabetic and hepatoprotective efficacy of dry extract from bearberry leaves enriched with arginine in dexamethasone induced IR. Materials and methods. IR was induced in rats by low dose intraperitoneally injections of dexamethasone. Dexamethasone-induced IR in rats was treated by bearberry leaves extract enriched with arginine. Thus, animals were randomized into several groups including intact animals and animals, which administered reference compounds and medications. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamine transferase (GGT) were determined in blood serum and liver homogenate, in addition, in blood serum we measured lactate dehydrogenase (LDH) activity and lactate level and glycogen content liver tissue. Also, for the purpose of our experiment, in liver tissue were determined: thiobarbituric acid reactive substances (TBARS), diene conjugates (DC), and reduced glutathione (GSH) content; and superoxide dismutase (SOD), glutathione peroxidase (Gpx), and catalase (CAT) activities. All indices were determined using generally accepted unified methods or commercially available kits. Results. Long-term dexamethasone administration led to an increase in AST, ALT and GGT overall activity in the liver homogenate and serum; this could be the result of increased permeability of hepatocyte plasma membranes, as well as their enhanced synthesis in the liver. Studied extract ameliorate these indices of liver injury. Evaluation of indices that reflected oxidative stress and the antioxidant system status in liver confirmed oxidative stress development in IR rats` liver. Administration of arginine enriched bearberry leaves extract decrease TBARS and DC content in liver tissue, at the same time, improve SOD, Gpx, and CAT activities and increase GSH content. Conclusions. Bearberry leaves dry extract enriched with arginine inhibit oxidative stress development, improve membrane integrity, and normalize some indices of carbohydrate metabolism, particularly glycogen content in liver and lactate level in blood.

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Section: Discussionmentioning

confidence: 94%

Study of hepatoprotective effect of bearberry leaves extract under insulin resistance in rats

Mazen¹,

Kravchenko²,

Krasilnikova³

2021

Eureka: HS

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“…In type 2 diabetic patients, l-lactate concentrations are positively associated with body weight, body mass index, triglyceride and insulin concentrations and negatively associated with adiponectin concentrations. 6 There is a decreased insulin sensitivity in overweight and obese horses and ponies and also in a subset of animals with PPID. 33,34 A similar association between obesity, ID, and increased blood l-lactate concentrations could therefore be present in equids leading to the hypotheses that blood l-lactate concentrations are higher in ponies with increased autumnal ACTH concentrations or evidence of ID and would correlate with measures of endocrine health.…”

Section: Discussionmentioning

confidence: 99%

“…The study did not identify any correlation between blood l‐lactate concentrations and the investigated measures of endocrine health and blood l‐lactate concentrations were not different between ponies with and without increased autumnal ACTH concentrations and with and without ID. In type 2 diabetic patients, l‐lactate concentrations are positively associated with body weight, body mass index, triglyceride and insulin concentrations and negatively associated with adiponectin concentrations 6 . There is a decreased insulin sensitivity in overweight and obese horses and ponies and also in a subset of animals with PPID 33,34 .…”

Section: Discussionmentioning

confidence: 99%

“…5 However, endocrine diseases that affect the insulin sensitivity of tissues can also influence glucose and l-lactate metabolism. Adipose tissue is thought to play an important role in supplying l-lactate 6 and l-lactate is a signaling molecule with autocrine, paracrine, and endocrine-like effects. 1 In people, higher blood l-lactate concentrations occur in association with obesity and type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Influence of endocrine disease on l‐lactate concentrations in blood of ponies

Dunkel

Knowles

Chang

et al. 2021

Veterinary Internal Medicne

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Background: Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives: To investigate whether blood l-lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumnal ACTH concentrations in ponies. Animals: Systemically healthy client-owned ponies (n = 101). Methods: Prospective case-control study. Blood samples were obtained from 101 clinically healthy ponies. Breed, weight, height, and subjective and objective measures of body condition were recorded. Blood l-lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations were measured and an oral sugar test (OST) was carried out. Correlations between blood l-lactate and variables of endocrine health were determined.Results: Using a seasonal cutoff point of ACTH concentrations ≥47 pg/mL, 55 ponies had increased autumnal ACTH concentrations and 45 did not. Using a basal insulin concentration of >50 μiU/mL, 42 ponies were diagnosed with ID and 58 were not. Using a 60 minutes after OST cutoff point of >45 μiU/mL, 57 ponies had ID and 37 did not. Blood l-lactate concentrations were significantly lower in obese (average body condition score ≥ 7/9

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“…Excessive adipose tissue is also common in diabetes mellitus (DM) and may contribute to an increase in lactate levels [ 14 ]. Lactate has also been explored as a possible biomarker of chronic DM complications, and an association has been suggested between microalbuminuria and diabetic nephropathy [ 15 ] and liver dysfunction [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Does the Same Hyperlactatemia Cut-Off in the Context of Acute Diseases Hold the Same Meaning in Diabetes Mellitus?

Vieira¹,

Petrova²,

Moura³

2022

Cureus

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Background Hyperlactatemia is defined by a lactate concentration of >2 mmol/L, and a lactate concentration of above >4 mmol/L is commonly used to define severe hyperlactatemia. It is a common disorder in critically ill patients and is associated with adverse prognosis. Diabetes mellitus(DM) can also be associated with increased lactate levels at baseline. In this study, we aimed to document the development of severe hyperlactatemia in acute situations among patients with and without DM, to analyze potential contributors to lactate elevation and their impact on mortality, and to analyze whether lactate concentrations of >4 mmol/L have equal prognostic significance in patients with and without DM. Methodology A retrospective, cross-sectional study was performed among patients admitted to our internal medicine wards in the context of acute disease with lactate concentrations of ≥2 mmol/L. Data were collected regarding age, sex, highest lactate concentrations, cause of hyperlactatemia, DM, and mortality. Statistical analysis was performed using SPSS version 23. Results In total, 151 patients with lactate levels of ≥2 mmol/L were analyzed. The mean age of the patients was 78.2 ± 14.9 years, and 55% of the patients were female. Overall, 55.6% of the patients had DM, as well as higher lactatemia of 6.3 ± 3.4 mmol/L (vs 5.1 ± 3.2 in non-DM patients, p = 0.003), with the majority reaching values of >4 mmol/L (vs 34.8% in non-DM patients). When potential contributors to the development of severe hyperlactatemia (lactate >4 mmol/L) were analyzed in DM patients, metformin consumption concomitantly with factors potentiating its accumulation, sepsis/septic shock, ischemia, and neoplasia were the most frequently identified contributors. In non-DM patients, the three former factors were also the most frequently reported. The 30-day mortality rate was 25.82%, with deceased patients also displaying a higher lactatemia of 6.5 ± 3.2 mmol/L (vs. 5.5 ± 3.3 mmol/L in patients who survived) (p = 0.037). In multivariate analysis, lactate values of >4 mmol/L were an independent predictor of mortality in the entire sample and in the subgroup without DM, but not in DM patients. Conclusions In our sample, patients with DM had higher lactate levels than non-DM patients. Our analysis raises the possibility that the same lactate values may not have equal capacity to assess prognosis in acute situations in patients with and without DM. Large-scale studies are needed to optimize cut-off points for lactatemia in patients with high baseline values, such as DM patients.

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Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: A cross-sectional study

Cited by 11 publications

References 45 publications

Study of hepatoprotective effect of bearberry leaves extract under insulin resistance in rats

Study of hepatoprotective effect of bearberry leaves extract under insulin resistance in rats

Influence of endocrine disease on l‐lactate concentrations in blood of ponies

Does the Same Hyperlactatemia Cut-Off in the Context of Acute Diseases Hold the Same Meaning in Diabetes Mellitus?

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