Serum lactic dehydrogenase activity in patients with prosthetic heart valves: A parameter of intravascular hemolysis

Myhre, E; Rasmussen, Knut; Andersen, Anders

doi:10.1016/0002-8703(70)90192-4

Cited by 57 publications

(21 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have demonstrated a decreased platelet survival in patients with prosthetic heart valves (7,13,24,25), and it was suggested that the shortened survival is due to direct damage of platelets by the prostheses similar to red blood cell destruction by the artificial valve (7,8,17,19).…”

Section: Resultsmentioning

confidence: 99%

Plasma Concentration of Platelet-Specific Proteins and Fibrinopeptide A in Patients with Artificial Heart Valves

Dudczak¹,

Niessner²,

Thaler³

et al. 1981

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

β-Thromboglobulin (βTG), platelet factor 4 (PF4), fibrinopeptide A (FPA), lactic dehydrogenase (LDH), and platelet count were evaluated in patients with bioprostheses and prosthetic heart valves. βTG and PF4 were significantly elevated in both patient groups (p < 0.001), whereas FPA was normal. There was no significant difference in plasma concentrations of βTG and PF4 between patients with prosthetic heart valves and bioprostheses. LDH levels were significantly (p < 0.001) higher and platelet count lower (p < 0.001) in patients with prosthetic cardiac valves. The data indicate that bioprostheses do not cause haemolysis or activation of the coagulation system. The findings that the plasma concentration of platelet-specific proteins were elevated, support the assumption that both types of valves cause platelet damage.

show abstract

Section: Resultsmentioning

confidence: 99%

Plasma Concentration of Platelet-Specific Proteins and Fibrinopeptide A in Patients with Artificial Heart Valves

Dudczak¹,

Niessner²,

Thaler³

et al. 1981

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

show abstract

“…2,6,7,10) On the other hand, several markers including increased reticulocyte count, schistocyte count, and serum lactate dehydrogenase, or reduced haptoglobin have been applied to estimate the severity of intravascular hemolysis. 1,2,6,7,[18][19][20][21][22][23][24] Among these markers, serum lactate dehydrogenase has been widely used to estimate the severity of intravascular hemolysis in patients with cardiac valve prostheses, because a close relation between serum lactate dehydrogenase and half-life of 51 Crlabeled erythrocytes was demonstrated in patients with cardiac valve prostheses.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Intravascular Hemolysis With Erythrocyte Creatine in Patients With Aortic Stenosis

et al. 2016

View full text Add to dashboard Cite

SummaryChronic intravascular hemolysis has been identified in patients with cardiac valve prostheses, but only a few case reports have evaluated intravascular hemolysis in patients with native valvular heart disease. To detect intravascular hemolysis in patients with aortic stenosis, erythrocyte creatine was evaluated with hemodynamic indices obtained by echocardiography.Erythrocyte creatine, a marker of erythrocyte age, was assayed in 30 patients with aortic stenosis and 10 aged matched healthy volunteers. Peak flow velocity of the aortic valve was determined by continuous-wave Doppler echocardiography. Twenty of 30 patients with aortic stenosis had high erythrocyte creatine levels (> 1.8 µmol/g Hb) and erythrocyte creatine was significantly higher as compared with control subjects (1.98 ± 0.49 versus 1.52 ± 0.19 µmol/g Hb, P = 0.007). Peak transvalvular pressure gradient ranged from 46 to 142 mmHg and peak flow velocity ranged from 3.40 to 5.95 m/second. Patients with aortic stenosis had a significantly lower erythrocyte count (387 ± 40 versus 436 ± 42 × 10 4 µL, P = 0.002) and hemoglobin (119 ± 11 versus 135 ± 11 g/L, P < 0.001) as compared with control subjects. Erythrocyte creatine had a fair correlation with peak flow velocity (r = 0.55, P = 0.002).In conclusion, intravascular hemolysis due to destruction of erythrocytes was detected in patients with moderate to severe aortic stenosis and the severity of intravascular hemolysis was related to valvular flow velocity of the aortic valve. (Int Heart J 2016; 57: 430-433)

show abstract

“…Measurement of serum LDH (specific red cell isoenzyme) is a sensitive method of estimating intravascular haemolysis (Myhre et al, 1970). It was raised in all our patients with Starr-Edwards prostheses but in only a third of patients with…”

Section: Discussionmentioning

confidence: 90%

Intravascular haemolysis after valve replacement: comparative study between Starr-Edwards (ball valve) and Bjork-Shiley (disc valve) prosthesis.

Falk¹,

MacKinnon²,

Wainscoat³

et al. 1979

Thorax

View full text Add to dashboard Cite

Seventy-four patients with single prosthetic valves (Bjbrk-Shiley or Starr-Edwards) in the mitral or aortic position and 18 controls with rheumatic valvar heart disease were investigated for evidence of intravascular haemolysis. Serum lactate dehydrogenase (LDH) was used as the most sensitive indicator of haemolysis. Raised concentrations were found in a third of 39 patients with Bj6rk-Shiley prostheses (mean 281 IU/1) and in all 35 patients with Starr-Edwards prostheses (mean 859 IU/l. Values were considerably higher in patients with Starr-Edwards prostheses and particularly in those with aortic prostheses (mean 927 lU/1).

show abstract

Serum lactic dehydrogenase activity in patients with prosthetic heart valves: A parameter of intravascular hemolysis

Cited by 57 publications

References 8 publications

Plasma Concentration of Platelet-Specific Proteins and Fibrinopeptide A in Patients with Artificial Heart Valves

Plasma Concentration of Platelet-Specific Proteins and Fibrinopeptide A in Patients with Artificial Heart Valves

Evaluation of Intravascular Hemolysis With Erythrocyte Creatine in Patients With Aortic Stenosis

Intravascular haemolysis after valve replacement: comparative study between Starr-Edwards (ball valve) and Bjork-Shiley (disc valve) prosthesis.

Contact Info

Product

Resources

About