Serum lactic dehydrogenase isoenzymes in "myxoedema heart disease".

Aber, Clive P.; Noble, R. L.; Thompson, G. S.; Jones, E. Sherwood

doi:10.1136/hrt.28.5.663

Cited by 14 publications

(4 citation statements)

References 19 publications

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“…Isoenzymes in patient ATJ were not indicative of myocardial damage because the isoenzyme pattern showed essentially a normal percentage of distribution. Abel et al, however, have reported that the LDH isoenzyme pattern in "myxedema heart disease" is similar to that seen with an acute myocardial infarction (20). SGOT levels were elevated in both of the present patients; however in patient ATJ the level returned to normal before institution of thyroid hormone therapy.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism presenting as a polymyositis‐like syndrome. Report of two cases

et al. 1976

Arthritis & Rheumatism

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Two patients with proximal muscle weakness and marked elevations of serum muscle enzymes were initially believed to have polymyositis; however electromyography and muscle biopsies were normal. Both patients were subsequently found to have hypothyroidism. Each regained her muscle strength, and serum enzymes normalized with thyroid hormone replacement. Because muscle weakness and an elevated creatine phosphokinase occur in most patients with hypothyroidism, thyroid dysfunction must be considered in the differential diagnosis of polymyositis.Polymyositis is characterized clinically by symmetric proximal muscle weakness and, less frequently, by muscle pain and tenderness. Chemically, the levels of Submitted for publication February 10, 1976: accepted April 19, 1976 serum enzymes concentrated in skeletal muscle are almost invariably elevated. It is not well appreciated that hypothyroidism can present as a muscular syndrome indistinguishable both clinically and chemically from polymyositis, with few of the stigmata usually associated with thyroid hormone deficiency.It is the purpose of this report to describe 2 patients initially believed to have polymyositis on the basis of severe proximal myopathy with profound serum muscle enzyme elevations. Both were subsequently found to have primary hypothyroidism. The discriminating clinical and laboratory features are discussed, and the muscular abnormalities associated with hypothyroidism are reviewed. CASE REPORTS Patient 1RL, a 34-year-old Latin American housewife, was admitted to The Wilford Hall USAF Medical Center for evaluation of progressive proximal limb-girdle muscle pain and weakness of 4 months duration. Past health had been good, except for depressive symptoms of 3 years duration. In addition to muscular pain and weakness, she complained of paresthesias of the first four fingers of both hands and of periorbital swelling not associated with skin rash. There was no history of articular pain or of swelling, alopecia, or sicca symptoms.Physical examination disclosed an obese, chronically ill appearing white female. The pulse was 68/minute, blood pressure 110/60 mm Hg. and temperature normal. The skin revealed periungual erythema, and the hair was fine and dry. The thyroid gland was neither enlarged nor nodular. All

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Section: Discussionmentioning

confidence: 99%

Hypothyroidism presenting as a polymyositis‐like syndrome. Report of two cases

et al. 1976

Arthritis & Rheumatism

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“…Using vertical starch-gel electrophoresis, Aber et al (1966) made LDH isoenzyme studies on 48 patients who suffered from hypothyroidism, and in 17 of them accentuation of LDH-1 and 2 was present.…”

Section: Resultsmentioning

confidence: 99%

Interrelationship between Serum Muscle Enzymes and a Low T3 in Anorexia Nervosa.

et al. 1990

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To determine the interrelationship between muscle dysfunction and a low T3 state, both seen in anorexia nervosa, we studied the relationship between the degree of muscle involvement, as assessed by the circulating concentration of the three muscle indicators (CPK, GOT and LDH), and serum T3 in thirtythree patients when they were admitted to the hospital.We also studied the malnutritional state, as assessed by their body weight or serum GH, serum potassium and the degree of hyperactivity exhibited. Additionally, another twelve patients were studied in order to explore the mounding phenomenon which is typically elicited in hypothyroidism.The logarithms of serum CPK and GOT correlated only with the serum T3 concentration (r=-0.35, p<0.05; r=-0.41, p<0.05; respectively). The logarithm of serum LDH highly correlated with serum

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“…Thompson and Whittaker (1965) drew attention to the elevation of pseudocholinesterase activity in thyrotoxicosis. Abner et al (1966) found elevated serum lactate dehydrogenase and alterations of the isoenzyme pattern in patients with myxoedema, Recently in a case of thyrotoxicosis, an unexplained elevation of the serum isocitrate dehydrogenase (ICD) activity was found while other liver function tests were normal. This finding has been inevestigated in sera from patients with abnormal protein bound iodine (PBI) levels to establish the frequency of elevated ICD activity in thyroid disease.…”

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confidence: 97%