Serum LDH in Preeclampsia &amp; Eclampsia and Maternal Outcomes

Agrawal, Pratibha; Savli, Anuradha; Rajoria, Lata; Vyas, Jyotsana; Balsane, Rujuta; Gupta, Surbhi

doi:10.21276/sjams.2016.4.6.37

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Jaiswar SP et al, also demonstrated a significant rise in the LDH levels with increasing severity of the disease ( P < 0.001). 3 1,[7][8][9][10][11][12][13][14][15][16][17] In this study, systolic and diastolic BP were significantly higher in patients with higher serum LDH levels .Similar reports were shown by Jaiswar SP et al, Aziz R, Mahboob T et al, Sarkar PD et al, Md Sabiullah et al, Sonagra A et al and Afraz R et al 3,8,9,10,12,14 In a study conducted by Martin JN et al, a high serum level of LDH (1400 IU/L) were shown to have a high predictive value for significant maternal morbidity. 16 Catanzerite VA et al reported that subgroup of patients who had elevated levels of LDH manifested with haemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome and were at high risk for developing maternal mortality.…”

Section: Resultsmentioning

confidence: 99%

Serum lactate dehydrogenase: a prognostic factor in pre-eclampsia

Mehta

Parashar

Kumar

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Pre eclampsia is responsible for significant maternal and perinatal morbidity and mortality worldwide .Serum LDH level is a useful biomarker for cellular injury which may reflect the severity of pre eclampsia and its level might be a guideline for management of patients. The aim of study was to find out the role of serum LDH in prediction of adverse outcome of pre eclampsia, severity of disease and occurrence of complications.Methods: This prospective observational study was conducted in the department of Obstetrics and Gynecolog, RIMS, Ranchi, Jharkhand, India. A total of 300 cases were studied.150 cases were non severe preeclamptic and 150 cases were severe pre eclamptic patients. Serum LDH was done in both non severe and severe eclamptic patients .Data entry was done in Microsoft excel 2007. Results were analysed by chi square test.Results: Higher LDH levels had significant correlation with high blood pressure as well as poor maternal and perinatal outcome.Conclusions: High serum LDH level correlate well with the severity of disease and poor outcome in patients of pre eclampsia. Detection of high risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.

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Section: Resultsmentioning

confidence: 99%

Serum lactate dehydrogenase: a prognostic factor in pre-eclampsia

Mehta

Parashar

Kumar

2019

Int J Reprod Contracept Obstet Gynecol

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“…Similar to our results, results were observed by Andrews L et al 18 with significant rise in the LDH levels with increasing severity of the disease, normotensive (172.37 +/-28.09), mild preeclampsia (356.33+/-24.47), severe pre-eclampsia (609.91+/-136.92) & eclampsia (854.05 +/-247.45) (p < 0.0001). Agrawal P et al 19 conducted a study to determine the correlation of serum LDH in pre-eclampsia and eclampsia and perinatal outcome. This is a hospital-based case control study done on 140 subjects including normotensive, mild pre-eclamptic, severe pre-eclamptic and eclamptic pregnant women after 28 weeks of gestation before termination of pregnancy.…”

Section: Groupmentioning

confidence: 99%

To Study Levels of LDH in Normal Pregnancy, Pre-Eclampsia & Eclampsia

Kulkarni¹,

Shaikh²

2019

jemds

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BACKGROUND Hypertension during pregnancy is a major health problem. Hypertensive disorders of pregnancy (preeclampsia, eclampsia) are common medical complications and affect 10% pregnancies. These pregnancies are at increased risk for maternal complications like abruption, disseminated intravascular coagulation, HELLP syndrome, pulmonary oedema, stroke, hepatic failure and renal failure. Foetal complications include growth restriction, prematurity and death of foetus. Early screening of gestational hypertension and preeclampsia may reduce the maternal and foetal complications. METHODS We conducted this study of levels of LDH in normotensive pregnancy, preeclampsia and eclampsia. This is a hospital based comparative cross-sectional study conducted in the department of Obstetrics & Gynaecology, Bharati Vidyapeeth Medical College and Hospital, Sangli, from December 2015 to July 2017. Out of a total of 150 patients included in present study, 50 patients were in normotensive group, 50 in preeclampsia group and 50 were in eclampsia group. Along with blood investigations, LDH levels were studied in all three groups. RESULTS Mean LDH was 257.24 U/L in normotensive patients as compared to 417.84 U/L in patients with pre-eclampsia and 565.51 in patients with eclampsia. LDH levels were found to be raised in pre-eclampsia and eclampsia patients and was statistically significant. CONCLUSIONS Serum LDH is the earliest marker in blood during hypoxia and oxidative stress. It is raised in cases of pre-eclampsia and eclampsia. Detection of high-risk patients with increased levels of LDH mandates close monitoring, prompt and correct management to decrease both maternal and foetal morbidity and mortality. Estimation of serum Lactate Dehydrogenase can be used as a prognostic marker for preeclampsia and eclampsia.

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Serum LDH in Preeclampsia & Eclampsia and Maternal Outcomes

Cited by 2 publications

References 3 publications

Serum lactate dehydrogenase: a prognostic factor in pre-eclampsia

Serum lactate dehydrogenase: a prognostic factor in pre-eclampsia

To Study Levels of LDH in Normal Pregnancy, Pre-Eclampsia & Eclampsia

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