Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma

Baek, Heysung; Shin, Jae Hoon; Kim, Joo Hwa; Oh, Jae‐Won; Lee, Ha Baik

doi:10.1016/j.anai.2011.03.013

Cited by 82 publications

(74 citation statements)

References 41 publications

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“…Previous studies have also reported adiponectin to be 50% lower in obese children and adults, compared with their nonobese counterparts [26,27]. In our study, serum adiponectin was reduced in asthmatic and nonasthmatic obese children, compared with nonobese controls.…”

Section: Discussionsupporting

confidence: 63%

Airway and systemic inflammation in obese children with asthma

et al. 2013

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Obese asthma presents via altered airway and systemic inflammation in adults. This has not been comprehensively described in children. The aim of the present study was to compare airway and systemic inflammation in obese and nonobese asthmatic children and controls.In a cross-sectional study, children aged 8-17 years were assigned to one of four groups: obese asthma (OA, n574); nonobese asthma (NOA, n5249); obese control (OC, n59); nonobese control (NOC, n529). Lung function, and both sputum and systemic inflammatory biomarkers were measured.Non-eosinophilic asthma was more prevalent among OA females (60.0%) versus OA males (30.8%). However, there were no differences in the percentage of eosinophils or neutrophils between OA and NOA. Leptin was higher in OC, but not OA, versus NOA and NOC, while adiponectin was reduced in OA versus NOC only. Expiratory reserve volume was reduced in OA, versus NOC. Residual volume (RV) and RV/total lung capacity were reduced in OC versus OA, and OC versus OA and NOA, respectively.Obesity was associated with significant lung restriction in children with and without asthma. Obesity was not associated with significantly altered airway or systemic inflammation in asthmatic children. However, the higher prevalence of non-eosinophilic asthma in female obese asthmatics, compared to males, warrants further investigation. @ERSpublications Obesity linked to lung restriction in non-and asthmatic children but not altered airway or systemic inflammation http://ow.ly/nm2VY

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Section: Discussionsupporting

confidence: 63%

Airway and systemic inflammation in obese children with asthma

et al. 2013

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“…This imbalance promotes pro-inflammatory responses and leads to inflammation (99)(100)(101) . A link between these adipokines was found in paediatric (102) and adult populations, with a stronger relationship observed in female, rather than male, individuals (41,103) . Receptors for leptin have been found in lung tissue (104) and various studies have observed increased concentrations of adipokines in asthmatic and allergic patients (102,103) .…”

Section: Possible Linksmentioning

confidence: 99%

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

2016

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Obesity is a risk factor for asthma, and obese asthmatics have lower disease control and increased symptom severity. Several putative links have been proposed, including genetics, mechanical restriction of the chest and the intake of corticosteroids. The most consistent evidence, however, comes from studies of cytokines produced by the adipose tissue called adipokines. Adipokine imbalance is associated with both proinflammatory status and asthma. Although reverse causation has been proposed, it is now acknowledged that obesity precedes asthma symptoms. Nevertheless, prenatal origins of both conditions complicate the search for causality. There is a confirmed role of neuro-immune cross-talk mediating obesityinduced asthma, with leptin playing a key role in these processes. Obesity-induced asthma is now considered a distinct asthma phenotype. In fact, it is one of the most important determinants of asthma phenotypes. Two main subphenotypes have been distinguished. The first phenotype, which affects adult women, is characterised by later onset and is more likely to be non-atopic. The childhood obesity-induced asthma phenotype is characterised by primary and predominantly atopic asthma. In obesity-induced asthma, the immune responses are shifted towards T helper (Th) 1 polarisation rather than the typical atopic Th2 immunological profile. Moreover, obese asthmatics might respond differently to environmental triggers. The high cost of treatment of obesity-related asthma, and the burden it causes for the patients and their families call for urgent intervention. Phenotype-specific approaches seem to be crucial for the success of prevention and treatment.

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“…27 But a recent study demonstrating associations between EIW and leptin and adiponectin in serum also lends support to the idea that EIW may have multiple etiologies. 28 Neighborhood asthma prevalence was only a statistically significant predictor of EIW among the seroatopic asthmatics; however, whether the risk conferred by living in neighborhoods is really modified by seroatopy or if the relatively small sample size among the nonseroatopics led to type-2 error remains to be determined.…”

Section: Figurementioning

confidence: 99%

Exercise-Induced Wheeze, Urgent Medical Visits, and Neighborhood Asthma Prevalence

et al. 2013

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OBJECTIVE: Exercise-induced wheeze (EIW) may identify a distinct population among asthmatics and give insight into asthma morbidity etiology. The prevalence of pediatric asthma and associated urgent medical visits varies greatly by neighborhood in New York City and is highest in low-income neighborhoods. Although increased asthma severity might contribute to the disparities in urgent medical visits, when controlling for health insurance coverage, we previously observed no differences in clinical measures of severity between asthmatic children living in neighborhoods with lower (3%–9%) versus higher (11%–19%) asthma prevalence. Among these asthmatics, we hypothesized that EIW would be associated with urgent medical visits and a child’s neighborhood asthma prevalence. METHODS: Families of 7- to 8-year-old children were recruited into a case-control study of asthma through an employer-based health insurance provider. Among the asthmatics (n = 195), prevalence ratios (PRs) for EIW were estimated. Final models included children with valid measures of lung function, seroatopy, and waist circumference (n = 140). RESULTS: EIW was associated with urgent medical visits for asthma (PR, 2.29; P = .021), independent of frequent wheeze symptoms. In contrast to frequent wheeze, EIW was not associated with seroatopy or exhaled NO, suggesting a distinct mechanism. EIW prevalence among asthmatics increased with increasing neighborhood asthma prevalence (PR, 1.09; P = .012), after adjustment for race, ethnicity, maternal asthma, environmental tobacco smoke, household income, and neighborhood income. CONCLUSIONS: EIW may contribute to the disparities in urgent medical visits for asthma between high- and low-income neighborhoods. Physicians caring for asthmatics should consider EIW an indicator of risk for urgent medical visits.

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Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma

Cited by 82 publications

References 41 publications

Airway and systemic inflammation in obese children with asthma

Airway and systemic inflammation in obese children with asthma

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

Exercise-Induced Wheeze, Urgent Medical Visits, and Neighborhood Asthma Prevalence

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