Serum leptin and osteoporosis in postmenopausal women with primary knee osteoarthritis

Elwakil, W.; Mohasseb, Diaa; Elkaffash, Dalal; Elshereef, Shereen; El-Shafey, Mohamed

doi:10.1016/j.ejr.2016.02.002

Cited by 9 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, lower serum OC was associated with increased mortality in women with T2DM [ 22 – 24 ]. This study confirmed an inverse correlation between HbA1c and OC levels in line with another study who reported a significant inverse relation between serum OC level and forearm BMD in patients with knee osteoarthritis (KOA) [ 25 ].…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Bone Mineral Density, Serum Osteocalcin, and Osteopontin Levels in Postmenopausal Women with Type 2 Diabetes Mellitus, with/without Osteoporosis

Roomi

Salih

Noori

et al. 2022

Journal of Osteoporosis

View full text Add to dashboard Cite

Objective. Osteoporosis (OP) is a worldwide ailment; we aim to establish new biomarkers in diagnosis by determining the levels of serum osteocalcin and osteopontin along with bone mineral density (BMD) and lumbar T-score, in postmenopausal women with type 2 diabetes mellitus (T2DM) with or without OP. Methods. This observational study included 160 postmenopausal women who were an attendee at outpatient clinics in Al-Hussein Hospital, Thi-Qar province; subdivided into 3 groups based on their T-score testing: Group I (n = 40) comprised postmenopausal women without T2DM as controls, Group II (n = 60) comprised postmenopausal women with T2DM but without OP, and Group III (n = 60) comprised postmenopausal women with T2DM with OP. The dual-energy X-ray absorptiometry was used to measure the BMD (total body, lumbar spine, and femoral) and T-score for lumbar spine and femoral. Glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), osteocalcin, and osteopontin levels were assessed in all three groups. Results. Compared with controls, Group III demonstrated significantly lower BMD (total body, lumbar spine, and femoral), T-score for lumbar spine and femoral, serum osteocalcin, and osteopontin levels than Group II and Group I ( P < 0.001 ). FBG and HbA1c levels were significantly higher in Group III than in Groups I and II ( P < 0.001 ). A negative correlation was proved between HbA1c levels with BMD, osteocalcin levels, and osteopontin levels in the three groups. Conclusions. Iraqi postmenopausal women with T2DM had a significantly lower bone mineral density, serum osteocalcin, and osteopontin levels. These results may serve as adjuvants in screening for OP, particularly among diabetic patients.

show abstract

Section: Discussionsupporting

confidence: 91%

Evaluation of Bone Mineral Density, Serum Osteocalcin, and Osteopontin Levels in Postmenopausal Women with Type 2 Diabetes Mellitus, with/without Osteoporosis

Roomi

Salih

Noori

et al. 2022

Journal of Osteoporosis

View full text Add to dashboard Cite

show abstract

“…These results are still contraversal, indicating that there is no leptin influence on bone metabolism (17), or demonstrating association of leptin and bone mineral density (18,19). Newer results indicate that leptin valuable marker in osteoporosis (20), and that increase in serum leptin correlated with bone mineral density increase in postmenopausal woman with primary knee osteoarthritis (21).…”

mentioning

confidence: 98%

Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures

et al. 2021

View full text Add to dashboard Cite

Background / Aim. Recent studies indicate that adipokines have important role in bone physiology and pathology. Recent data indicate that adipokine leptin functions as a regulator of bone growth at multiple levels, systemically and locally. So far, it has been shown that leptin influence bone volume and bone mineral density in a population with metabolic and/or hormonal abnormality. Data concerning leptin values in non-obese children with fractures are scarce. Methods. 93 non-obese children with long bone fractures (LBF), 14 children with short bone fractures (SBF) and 19 healthy children. Leptin concentration was determined in 2 blood samples (0d and 21d) and analyzed according to gender, fracture type, fracture anatomical localization, fracture topography, callus formation and the healing outcome. Results. Children with LBF demonstrated significantly increased leptin comparing to control group (both 0d/21d). In control group girls had significantly more leptin than boys. Leptin value was significantly influenced by anatomical localization, since boys and girls with humerus fracture and girls with femur fracture had the highest average leptin concentration in initial sample. Boys with incomplete callus formation had the highest leptin concentration (both 0d/21d) significantly elevated comparing to control boy samples, boys samples with intermediary and well formed callus and also increased comparing to initial samples of girls with incomplete callus. Better callus formation in girls was associated with increament of leptin concentrations in second over initial sample. Girls with partially and satisfactory formed callus had significantly increased leptin concentration in second sample (21d) comparing to boys group. Conclusion. Leptin concentration was significantly increased (both samples) in children with LBF comparing to children with SBF and corresponding controls. Leptin concetration was highly influenced by gender. High leptin in boys or low leptin concentration in girls immidiately upon fracture could be used to identify groups of children with incomplete callus formation. Abstrakt Uvod / Cilj. Nedavne studije pokazuju da adipokini imaju važnu ulogu u fiziologiji i patologiji kostiju. Najnoviji podaci ukazuju da adipokin leptin funkcioniše kao regulator rasta kostiju sistemski i lokalno. Pokazano je da leptin uti e na volumen kostiju i mineralnu Control 2.02 ± 0.22 a, e, h 1.67 ± 0.49 a 2.38 ± 0.41 B. sample all boys girls LBF 21 day 2.59 ± 1.43 2.40 ± 1.26 2.85 ± 1.57 long bone oblique 21 day 3.15 ± 1.81 3.63 ± 2.28 2.51 ± 0.98 type transverse 21 day 2.39 ± 1.27 2.17 ± 0.95 2.99 ± 1.85

show abstract

Association of bone mineral density and body mass index in a cohort of Pakistanis: Relation to gender, menopause and ethnicity

Akhlaque

Ayaz

Akhtar

et al. 2017

The Egyptian Rheumatologist

View full text Add to dashboard Cite

Serum leptin and osteoporosis in postmenopausal women with primary knee osteoarthritis

Cited by 9 publications

References 39 publications

Evaluation of Bone Mineral Density, Serum Osteocalcin, and Osteopontin Levels in Postmenopausal Women with Type 2 Diabetes Mellitus, with/without Osteoporosis

Evaluation of Bone Mineral Density, Serum Osteocalcin, and Osteopontin Levels in Postmenopausal Women with Type 2 Diabetes Mellitus, with/without Osteoporosis

Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures

Association of bone mineral density and body mass index in a cohort of Pakistanis: Relation to gender, menopause and ethnicity

Contact Info

Product

Resources

About