Serum Leptin Concentration Increase During Luteal Phase in Healthy Premenopausal Women

Łukaszuk, Krzysztof; Liss, J.R.; Kusiak, E; Wójcikowski, C

doi:10.1055/s-2007-978860

Cited by 23 publications

(17 citation statements)

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“…These observations confirm previous findings of an increase in serum leptin during the luteal phase of the cycle (13)(14)(15), but also highlight a potential role for leptin with regard to ovulation, as an early increase in circulating leptin occurs before or at the same time as the mid-cycle surge in LH and FSH concentration. Moreover, our study is also in accordance with a recent paper showing that estrogen-progestin therapy does not affect serum leptin concentrations (21).…”

Section: Discussionsupporting

confidence: 90%

“…On the other hand, administration of leptin antiserum to adult female rats leads to a marked decrease in luteinizing hormone (LH) pulsatility (8). In humans, several observations suggest that gonadal steroids might modulate leptin expression: (a) in women circulating leptin is higher than in men, even when adjusted for body mass index (BMI) and absolute fat mass (9,10); (b) among women serum leptin is higher in premenopausal than in menopausal subjects (11)(12)(13); (c) most authors agree that in cycling women circulating leptin is higher in the luteal phase than in the follicular phase (13)(14)(15); (d) plasma leptin concentrations increase at the onset of puberty (16,17); (e) both long and short isoforms of leptin receptors have been demonstrated in the human ovary (18).…”

Section: Introductionmentioning

confidence: 99%

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Serum leptin concentrations during the menstrual cycle in normal-weight women: effects of an oral triphasic estrogen-progestin medication

Cella

Giordano

Cordera

2000

European Journal of Endocrinology

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Objective: To investigate in normal-weight premenopausal women the relationship between circulating leptin and serum gonadotropins and gonadal steroids, during both spontaneous and pharmacologically induced menstrual cycles. Design: Clinical longitudinal study. Methods: Two groups of age-matched, normal-weight premenopausal volunteer women (groups I and II) were enrolled in this study. Women in group I were free of any hormonal treatment, while women in group II were taking a triphasic estrogen-progestin contraceptive preparation. Blood samples were collected daily in both groups after an overnight fast throughout a complete menstrual cycle. Results: In the spontaneously cycling women, serum leptin concentration positively correlated with estradiol (P < 0.03) and progesterone (P < 0.05) and was higher in the luteal than in the follicular phase (P < 0.05). However, a significant (P < 0.03) short-lasting increase in circulating leptin was present in the late follicular phase of all subjects. In the women using hormonal contraception serum leptin remained unchanged throughout the cycle, along with constantly low values of circulating luteinizing hormone and follicle-stimulating hormone. Conclusions: In normal-weight premenopausal women serum leptin concentrations differ during the menstrual cycle in line with changes in gonadotropin and gonadal steroid concentrations, increasing in the luteal phase of the cycle after a peri-ovulatory peak. These findings suggest a permissive role for leptin with regard to the functioning of the corpus luteum.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Serum leptin concentrations during the menstrual cycle in normal-weight women: effects of an oral triphasic estrogen-progestin medication

Cella

Giordano

Cordera

2000

European Journal of Endocrinology

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“…The results published to date on leptin levels in the menstrual cycle differ remarkably. Some studies showed significant increase of leptin in the late follicular phase (9, 10), some on the day of the LH surge onset (11,12), while others in the late luteal phase (13)(14)(15)(16)(17). Further studies reported small, non-significant variations during the menstrual cycle (18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies showed significant increase in the late follicular phase (9,10), and some did so on the day of the onset of the luteinising hormone (LH) surge (11,12). Other investigations described significant increase in serum leptin levels in the late luteal phase (13)(14)(15)(16)(17), and again others reported only small, not statistically significant variations during the menstrual cycle (18)(19)(20)(21). The acute phase C-reactive protein (CRP) is produced by the liver.…”

Section: Introductionmentioning

confidence: 99%

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Wunder¹,

Yared²,

Bersinger³

et al. 2006

eur j endocrinol

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Objective: Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammatory markers C-reactive protein (CRP) and leptin in the serum of healthy, normally ovulating women and to correlate these with each other and with the hormones of the gonadal axis. A cycle-dependence of the markers studied would imply an exact timing of the blood sampling for clinical needs. Design: Observational study investigating the two inflammatory markers CRP and leptin in relation to the hormonal pattern of the gonadal axis during the normal cycle. Methods: Ovulatory cycles of 36 healthy, young, normo-androgenic women, having a normal body mass index were evaluated. Serum concentrations of leptin and CRP, as well as of follicle-stimulating hormone, luteinising hormone, 17b-oestradiol, progesterone, prolactin (PRL) and free testosterone were measured every 1-2 days during one full cycle. Results: Serum levels of leptin and CRP behaved differently during ovulatory cycles, with higher concentrations for leptin only during certain phases. Significant correlations were found in the follicular phase between leptin and PRL and leptin and free testosterone. Conclusions: Leptin levels change during the menstrual cycle. Leptin levels are more stable on cycle days 1-5 than later in the cycle. For precise cycle-independent measurements, these fluctuations have to be taken into account. There is no similar cyclic pattern for CRP.European Journal of Endocrinology 155 137-142

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“…Some studies showed signifi cant increase in the late follicular phase, and some did so on the day of the onset of the luteinising hormone (LH) 24,25 . Other investigations described signifi cant increase in serum leptin levels in the late luteal phase [26][27][28][29][30][31] . Other authors reported only small, not statistically signifi cant variations during the menstrual cycle [32][33][34] .…”

Section: Discussionmentioning

confidence: 99%

The Influence of Estradiole and Tibolone Administration on Leptin Levels in Women With Surgically Induced Menopause

Petzel¹,

Stejskal²,

Jedelský³

et al. 2008

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background: Several studies suggest that changes in estrogens and androgens during menopause play a role in the regulation of leptin production. Some authors present hypothesis that sex hormone replacement therapy can modulate leptin levels but up to date evidence shows that the infl uence of endogenous estrogens, androgens levels and sex hormone therapy on leptin concentration remains uncertain.Aim: To evaluate the infl uence of surgically induced menopause on serum leptin levels and the infl uence of diff erent types of hormonal therapy on serum leptin concentrations.Methods: 58 women with surgically induced menopause were divided into three groups. Women who did not receive any hormonal substitution (group 1), women who received Estradiol l mg per day (group 2) and women who received Tibolone 2,5 mg per day (group3). The levels of leptin, estradiol, testosterone, testosterone, dehydroepiandrosterone sulfate, FSH, LH and progesterone were measured in all subjects on the 5th day and after 3 months following the surgical procedure.Results: Mean serum leptin concentrations did not diff er statistically in any of the studied groups in the begining and in the end of the study. There was no correlations between serum leptin and estradiol, LH, FSH, progesterone, testosterone, free testosterone and DHEAS concentrations in any of groups before and after treatment.Conclusion: Changes in sex hormone concentrations caused by ovariectomy do not infl uence serum leptin concentrations. Also the short term administration of low dose estrogen therapy or tibolone in postmenopausal subjects does not change serum leptin levels.

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Serum Leptin Concentration Increase During Luteal Phase in Healthy Premenopausal Women

Cited by 23 publications

References 1 publication

Serum leptin concentrations during the menstrual cycle in normal-weight women: effects of an oral triphasic estrogen-progestin medication

Serum leptin concentrations during the menstrual cycle in normal-weight women: effects of an oral triphasic estrogen-progestin medication

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

The Influence of Estradiole and Tibolone Administration on Leptin Levels in Women With Surgically Induced Menopause

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