Serum leptin concentrations during severe protein-energy malnutrition: Correlation with growth parameters and endocrine function

Soliman, Ashraf T.; Elzalabany, Mahmoud; Salama, Mohamed Magdy; Ansari, B. M.

doi:10.1053/meta.2000.6745

Cited by 99 publications

(104 citation statements)

References 47 publications

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“…The concentrations were similar to those found in children with marasmus and kwashiorkor (Soliman et al, 2000). We had no well-nourished children as controls because all the children involved in this study were from very low income families, but other studies have found leptin levels ranging from 2.8 to 5.4 ng=ml in children aged 1 -9 y (Ellis & Nicolson, 1997;Garcia-Mayor et al, 1997;Lonnerdal & Havel, 2000).…”

Section: Serum Leptin In Indian Childrensupporting

confidence: 79%

“…A more sensitive assay may have revealed a correlation, although other studies have also found no correlation of leptin with BMI at very low BMIs, suggesting a lower threshold effect (Argente et al, 1997;Casanueva et al, 1997). In the other study of severely malnourished children (Soliman et al, 2000), a correlation with BMI was found. However, in this study, although the leptin data appeared log -normally distributed, it is unclear whether the correlation analysis accounted for this.…”

Section: Serum Leptin In Indian Childrenmentioning

confidence: 81%

“…Childhood malnutrition differs from anorexia nervosa or weight reduction in obese patients in important ways: age of onset is earlier, the onset of the nutritional insult is less acute than in fasting (which may have different effects on lymphocyte numbers (Howard et al, 1999)), diet quality as well as quantity is usually poor, and immune system impairments are usually more severe in malnourished children (Marcos, 1997). One recent study has shown that Egyptian children suffering from marasmus or kwashiorkor had lower plasma leptin than wellnourished control children (Soliman et al, 2000). Information on leptin in less severe childhood malnutrition, that is, not requiring hospitalization, does not appear available.…”

Section: Introductionmentioning

confidence: 99%

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Serum leptin in disabled and non-disabled children in an Indian slum population

Yousafzai

Filteau

et al. 2002

Eur J Clin Nutr

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Objective: To assess the concentration of serum leptin in a population of malnourished children and to compare the leptin levels of disabled and non-disabled children in this population. Design: Case -control study. Subjects: Eighty-one children, comprising 41 children with mixed disabilities and 40 non-disabled controls, were selected from 425 children involved in a case -control study assessing the nutritional status of children with disabilities in an Indian slum population. Methods: Leptin was measured in the serum samples and was compared with anthropometry (weight-for-age Z-scores (WAZ), height-for-age Z-scores (HAZ), weight-for-height Z-scores (WHZ), body mass index (BMI), mid-upper-arm circumference (MUAC), sub-scapular skinfold thickness and triceps skinfold thickness) and serum acute phase proteins. Results: The children were very malnourished with WAZ ¼ 7 2.07 (s.d. 1.15), HAZ ¼ 7 2.15 (s.d. 1.85) and WHZ ¼ 7 1.07 (s.d. 0.83). Leptin was extremely low in both the disabled (1.44 ng=ml; 95% confidence interval, CI, 1.23 -1.69) and the nondisabled (1.19 ng=ml; 95% CI 1.04 -1.35) children. There were no differences between the disabled and non-disabled groups as a whole but 15 children with neurological disabilities had significantly higher (P < 0.05) serum leptin (1.65 ng=ml; 95% CI 1.29 -2.06) than the non-disabled children. Girls (1.55 ng=ml; 95% CI 1.29 -1.87) had significantly higher concentrations of leptin than boys (1.11 ng=ml; 95% CI 1.02 -1.22; P ¼ 0.002). Leptin did not correlate with any biochemical or anthropometric measures. Conclusions: In this population, where malnutrition was common, serum leptin levels were very low and did not correlate with anthropometry.

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Section: Serum Leptin In Indian Childrensupporting

confidence: 79%

Section: Serum Leptin In Indian Childrenmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum leptin in disabled and non-disabled children in an Indian slum population

Yousafzai

Filteau

et al. 2002

Eur J Clin Nutr

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“…Such negative correlations were also observed between the serum leptin concentration and basal 24 h GH secretory capacity (13) or stimulated GH release in children and adults (15,22,23). These results seem to indicate that circulating leptin has an inhibitory action on GH secretion.…”

Section: Discussionmentioning

confidence: 59%

“…It is reported that a negative relationship exists between the basal serum levels of leptin and GH in chronically hyponutritional children (22). Such negative correlations were also observed between the serum leptin concentration and basal 24 h GH secretory capacity (13) or stimulated GH release in children and adults (15,22,23).…”

Section: Discussionmentioning

confidence: 89%

The effects of human leptin fragment(126-140) on pituitary functions in man

Hanew

2003

European Journal of Endocrinology

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Objective: The effects of human leptin fragment(126 -140) on pituitary function in eight healthy, nonobese men were studied. Methods and design: The effects of the fragment on spontaneous secretion of pituitary hormones and endogenous leptin, as well as on GHRH-induced GH secretion were examined. Results: After the administration of the fragment (50 mg i.v. for 150 min), the mean nadir value and 45 min value were significantly lower than that of the control study. Endogenous leptin levels did not decrease significantly following the administration of the leptin fragment. Other pituitary hormones were not affected by the fragment. The area under the curve of the GH response to GHRH(1 -44)NH 2 (10 mg, i.v. from 0 to 75 min) was also significantly inhibited by the combined administration of the leptin fragment (100 mg i.v. from 2 30 to 75 min) (P , 0.001). Three subjects were re-examined with larger doses of the leptin fragment (200 -400 mg), and even greater GH suppression was observed. Conclusions: These results indicate that human leptin fragment(126 -140) has an inhibitory role in GH secretion, since when administered exogenously this fragment significantly suppressed spontaneous and, in a dose-response manner, GHRH-induced GH secretion. Clear effects of the fragment on other pituitary hormones and an inhibitory effect on endogenous leptin secretion were not observed in this study.

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Urinary cortisol and muscle mass in Turkana men

Lukas¹,

Campbell

2005

Am. J. Hum. Biol.

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To determine the role of cortisol in modulating the effects of energetics on muscle mass in a subsistence society, measures of cortisol and body composition were obtained from a sample of Turkana men. Subjects were 63 settled and 69 nomadic men, ages 24 and older. Urinary cortisol was determined along with measures of muscle mass. Cortisol/creatinine ratio was higher among nomadic men (57.8 +/- 56.8 vs. 34.5 +/- 44.6; P < 0.001). Controlled for age, urinary cortisol was inversely related to arm muscle plus bone area (MPBA) among the nomadic (beta = -0.28; P = 0.04), but not the settled (beta = -0.04; P = 0.78) sample. Urinary cortisol was not related to any other measures of body composition. These results suggest that even in chronically undernourished populations, cortisol may be elevated primarily under conditions of acute nutritional stress. However, the catabolic effects of cortisol on muscle in our results may be confounded by other energetic factors, including energy availability.

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Serum leptin concentrations during severe protein-energy malnutrition: Correlation with growth parameters and endocrine function

Cited by 99 publications

References 47 publications

Serum leptin in disabled and non-disabled children in an Indian slum population

Serum leptin in disabled and non-disabled children in an Indian slum population

The effects of human leptin fragment(126-140) on pituitary functions in man

Urinary cortisol and muscle mass in Turkana men

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