Serum Leptin Elevation in Obese Women with PCOS: A Continuing Controversy

Saleh, Hisham Ali; El-Nwaem, Mohamed Amr; El-Bordiny, Magdy; Maqlad, Hala Mohamed El-Sayed; El-Mohandes, Amr Ahmed; Eldaqaq, Ebtehag Mohamed

doi:10.1023/b:jarg.0000046204.81682.67

Cited by 17 publications

(10 citation statements)

References 39 publications

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“…We found significantly higher leptin levels when BMI and waist circumference increased in both patients and controls and in accordance with previous studies, close relations were demonstrated between leptin and measures of fat mass and insulin sensitivity (8,(42)(43)(44)(45)(46)(47). Our findings of insignificant associations between leptin and androgen levels are in agreement with previous studies (42,(44)(45)(46).…”

Section: Whr Adjustedsupporting

confidence: 93%

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Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls

et al. 2006

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Objective: Polycystic ovary syndrome (PCOS) patients are abdominally obese and are at increased risk of developing the metabolic syndrome. Low adiponectin and ghrelin levels in PCOS patients could be caused by insulin resistance as well as high testosterone levels. Design: Adiponectin and ghrelin levels were evaluated in 51 hirsute PCOS patients referred to the outpatient clinic of an academic, tertiary care medical centre and in 63 weight-matched female controls. Relationships between adiponectin, ghrelin, leptin, body composition, testosterone and insulin were examined. Methods: Measurements of body composition including waist-hip-ratio (WHR), body mass index (BMI) and whole body dual-energy X-ray absorptiometry scan measures of body fat mass. Measurements of fasting levels of adiponectin, ghrelin, leptin, androgen status, oestradiol, lipid variables and insulin during follicular phase. Results: Adiponectin levels were significantly decreased in obese PCOS patients compared with weightmatched controls (geometric mean (K2 to 2 S.D.) 5.3 (2.5-11.1) vs 7.3 (3.0-17.4) mg/l, P!0.05). Mean ghrelin was significantly lower in hirsute PCOS patients than in controls (0.6 (0.3 to 1.4) vs 0.8 (0.4 to 1.7) mg/l, P!0.001) and this remained significant after subdividing subjects according to waist circumference and BMI. During multiple regression analysis, testosterone correlated positively with adiponectin and negatively with ghrelin independent of BMI, WHR and total fat mass. Conclusion: Obese hirsute PCOS patients demonstrated significantly lower adiponectin levels than weight-matched controls suggesting a very high risk for the metabolic syndrome. Furthermore, ghrelin levels were decreased in hirsute PCOS patients and showed a significant, negative correlation with testosterone independent of body composition.European Journal of Endocrinology 155 337-345

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Section: Whr Adjustedsupporting

confidence: 93%

“…Our findings of insignificant associations between leptin and androgen levels are in agreement with previous studies (42,(44)(45)(46). Further supporting a minor relation between testosterone and leptin, Krotkiewski et al (48) found no significant changes of leptin levels during anti-androgen treatment in PCOS.…”

Section: Whr Adjustedsupporting

confidence: 93%

Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls

et al. 2006

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“…In contrast to adiponectin, elevated leptin levels are implicated in the pathogenesis of obesity and associated with insulin resistance (41). Recent studies have linked leptin levels to the degree of adiposity and insulin resistance in obese PCOS and control subjects (42,43). We did not find a significant difference in serum adiponectin and leptin levels in the two groups.…”

Section: Discussioncontrasting

confidence: 73%

Young Obese Women with Polycystic Ovary Syndrome Have Evidence of Early Coronary Atherosclerosis

Shroff

Kerchner

Maifeld

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

176

113

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Context: Polycystic ovary syndrome (PCOS) is associated with comorbidities that may contribute to increased risk of cardiovascular disease. PCOS is associated with increased risk of metabolic syndrome, dyslipidemia, and diabetes, but it remains unclear whether traditional cardiovascular (CV) risk factors can help predict coronary artery disease in this population. Objective:The objectives of the study were to detect early-onset subclinical coronary atherosclerosis (using coronary artery calcium as a marker) in young women with PCOS, compared with age-and body mass index-matched controls, and to compare traditional CV risk factors and inflammatory markers in the two groups.Design: This was a prospective case-control study. Setting:The study was conducted at a university hospital.Subjects: Twenty-four obese (body mass index Ն 30 kg/m 2 ) PCOS subjects and 24 obese controls participated.Outcome Measures: Coronary artery calcium, inflammatory markers (high-sensitivity C-reactive protein, IL-6, TNF␣, adiponectin, leptin), fasting blood tests (glucose, lipids, insulin), and dual-energy x-ray absorptiometry scan for body fat distribution were measured.Results: Coronary artery calcium was detected in eight of 24 PCOS subjects (33%) and two of 24 controls (8%) (odds ratio 5.5, 95% confidence interval 1.03, 29.45, P Ͻ 0.03). Traditional CV risk factors did not differ significantly between the two groups, nor did markers of inflammation or adiposity, body fat distribution, or metabolic parameters with the exception of significantly lower quantitative insulin sensitivity check index (marker for insulin resistance) in the PCOS group (P Ͻ 0.05). Conclusions:Young, obese women with PCOS have a high prevalence of early asymptomatic coronary atherosclerosis, compared with obese controls. This increased risk is independent of traditional CV risk factors and novel markers of inflammation. These findings underscore the need to screen and aggressively counsel and treat these women to prevent symptomatic CV disease.

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“…26 In this study, the leptin levels in controls and PCOS cases seemed to be much higher than those reported in different populations, including the United States, 27 Turkey, 28 and Egypt. 29 Leptin, as expected, was correlated with BMI in both controls and PCOS cases, confirming that leptin is an appropriate marker of obesity. 30 In addition, results from the present study suggest that age is positively correlated with age in PCOS cases.…”

supporting

confidence: 78%

Leptin-to-Adiponectin, Adiponectin-to-Leptin Ratios, and Insulin Are Specific and Sensitive Markers Associated with Polycystic Ovary Syndrome: A Case–Control Study from Bahrain

Golbahar

Das²,

Al-Ayadhi³

et al. 2012

Metabolic Syndrome and Related Disorders

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Serum Leptin Elevation in Obese Women with PCOS: A Continuing Controversy

Cited by 17 publications

References 39 publications

Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls

Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls

Young Obese Women with Polycystic Ovary Syndrome Have Evidence of Early Coronary Atherosclerosis

Leptin-to-Adiponectin, Adiponectin-to-Leptin Ratios, and Insulin Are Specific and Sensitive Markers Associated with Polycystic Ovary Syndrome: A Case–Control Study from Bahrain

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