Serum Leptin in Egyptian patients with fibromyalgia syndrome: relation to disease severity

Olama, Shereen Mohamed; Elsaid, Tamer O.; El-Arman, Mohammad

doi:10.1111/1756-185x.12155

Cited by 15 publications

(12 citation statements)

References 36 publications

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“…Serum levels of leptin, a hormone with a role in energy expenditure, fat regulation, and suppression of hunger, were measured in FM patients. [34][35][36] Only 1 study demonstrated lower leptin levels versus controls, which correlated with symptom severity. 34 Obesity in FM is associated with the same variables as in the general population, including lack of exercise, history of physical and sexual abuse, depression, medical comorbidities, hypothyroidism, the number of musculoskeletal surgeries, and the number of medications taken for FM.…”

Section: Discussionmentioning

confidence: 94%

“…Studies of obesity in the general population show that it is associated with medical comorbidities, 37 psychiatric pharmacotherapy, 38 depression, poor physical function, 34 and sexual and physical abuse. 39 To our knowledge, the relationship we observed between BMI and the number of medical comorbidities has not been previously reported in an FM cohort, although it has been demonstrated in the general population.…”

Section: Discussionmentioning

confidence: 99%

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Fibromyalgia and Obesity

Gota

Kaouk

Wilke³

2015

JCR: Journal of Clinical Rheumatology

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Compared with normal-weight patients, obese FM patients are more disabled, report more medical comorbidities, exercise less, have a higher incidence of abuse, report increased depressive symptoms, and take more medications for FM. Bivariate analysis showed association of increasing BMI with the Health Assessment Questionnaire Disability Index (not FM impact questionnaire) and depression. We confirm that the prevalence of overweight and obesity is high in FM and believe that physicians treating FM should be aware of our bivariate linear correlations and discuss weight loss with their FM patients. Even if increasing BMI is not intrinsic to FM, it contributes to poor mood and functional outcome and should be a treatment goal.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Fibromyalgia and Obesity

Gota

Kaouk

Wilke³

2015

JCR: Journal of Clinical Rheumatology

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“…However, such study failed to adjust the leptin levels by fat mass or stratify them by BMI (30). These authors demonstrated that leptin levels were significantly lower in patients with fibromyalgia than in controls.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Paiva

Andretta

Batista

et al. 2017

Arch. Endocrinol. Metab.

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Objectives: The objectives of this study were to evaluate the serum levels of adipokines in women with fibromyalgia with and without overweight/obesity, and to correlate the adipokines levels with clinical parameters associated with fibromyalgia and adipose tissue mass (body fat). Subjects and methods: The study included 100 women divided into four groups: (a) fibromyalgia and overweight/obesity; (b) fibromyalgia and normal weight; (c) controls and overweight/obesity; and (d) controls and normal weight. Patients and controls were evaluated for clinical, anthropometric, and fibromyalgia-related parameters. Assessments included serum levels of leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP). Levels of adipokines were further adjusted for fat mass. Results: Fibromyalgia patients with overweight/obesity or normal weight had no differences in clinical parameters. Unadjusted leptin levels were lower in fibromyalgia patients than controls, a finding that was more remarkable in fibromyalgia patients with overweight/obesity. Leptin levels had no correlation with clinical parameters of fibromyalgia or inflammation markers (MCP-1 and CRP), and adiponectin levels showed no difference between groups. Conclusions: No correlation was observed between adjusted leptin levels and clinical parameters of fibromyalgia. Patients with fibromyalgia and overweight/obesity presented lower levels of leptin than controls with overweight/ obesity. Arch Endocrinol Metab. 2017;61(3):249-56.

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“…Pancreas and fatty tissue appear to be influential among the mechanisms that regulate appetite, the central nervous system, the gastrointestinal system (GIS), several anorexigenic and orexigenic peptides, and hormonal mediators released from the adrenals (1)(2)(3)(4)(5). Particular emphasis is being put on the leptin and ghrelin system in the pathophysiology of many diseases that affect appetite (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder

Gürbüz

Çelik

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7-14 years. Following treatment, patients' leptin levels increased and ghrelin levels decreased while no significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.

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Serum Leptin in Egyptian patients with fibromyalgia syndrome: relation to disease severity

Abstract: We found a significant decrease in serum leptin in FMS patients compared to controls and this decrease correlated with disease severity.

Cited by 15 publications

References 36 publications

Fibromyalgia and Obesity

Fibromyalgia and Obesity

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder

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