Serum Leptin Levels and Lipid Profiles in Patients with Allergic Rhinitis and Mild Asthma

Erel, Fuat; Güleç, Mustafa; Özgür, Kemal; Çalışkaner, Zafer; Öztürk, Sami; Yaman, Halıl; Kurt, Yasemin Gülcan; Gocgeldic, E; Örs, Fatih; Karaayvaz, Mehmet

doi:10.1157/13112988

Cited by 19 publications

(19 citation statements)

References 29 publications

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“…Although prior studies have also assessed the relationship between serum HDL-C and asthma, the results have been heterogeneous with serum HDL-C levels either being increased, decreased, or unchanged in subjects with asthma (20,(43)(44)(45)(46)(47)(48)(49)(50). Similar to our findings, prior studies have also not found a change in serum LDL-C in subjects with asthma, whereas TC was either decreased or unchanged and TG levels were either increased or unchanged.…”

Section: Discussionsupporting

confidence: 80%

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Barochia¹,

Kaler²,

Cuento³

et al. 2015

Am J Respir Crit Care Med

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Rationale: Although lipids, apolipoproteins, and lipoprotein particles are important modulators of inflammation, varying relationships exist between these parameters and asthma.Objectives: To determine whether serum lipids and apolipoproteins correlate with the severity of airflow obstruction in subjects with atopy and asthma.Methods: Serum samples were obtained from 154 atopic and nonatopic subjects without asthma, and 159 subjects with atopy and asthma. Serum lipid and lipoprotein levels were quantified using standard diagnostic assays and nuclear magnetic resonance (NMR) spectroscopy. Airflow obstruction was assessed by FEV 1 % predicted.Measurements and Main Results: Serum lipid levels correlated with FEV 1 only in the subjects with atopy and asthma. Serum levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) were positively correlated with FEV 1 in subjects with atopy and asthma, whereas a negative correlation existed between FEV 1 and serum levels of triglycerides, low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apoB), and the apoB/apoA-I ratio. NMR spectroscopy identified a positive correlation between FEV 1 and HDL NMR particle size, as well as the concentrations of large HDL NMR particles and total IDL NMR (intermediate-density lipoprotein) particles in subjects with atopy and asthma. In contrast, LDL NMR particle size and concentrations of LDL NMR and VLDL NMR (very-low-density lipoprotein) particles were negatively correlated with FEV 1 in subjects with atopy and asthma.Conclusions: In subjects with atopy and asthma, serum levels of apoA-I and large HDL NMR particles are positively correlated with FEV 1 , whereas serum triglycerides, LDL cholesterol, and apoB are associated with more severe airflow obstruction. These results may facilitate future studies to assess whether apoA-I and large HDL NMR particles can reduce airflow obstruction and disease severity in asthma.

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Section: Discussionsupporting

confidence: 80%

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Barochia¹,

Kaler²,

Cuento³

et al. 2015

Am J Respir Crit Care Med

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“…In fact, a first study reported that serum leptin levels were found to be significantly higher in patients with allergic rhinitis in the symptomatic period than normal controls (Unal, 2006). A next study demonstrated that the serum levels of leptin on allergic rhinitis were not different than in controls (Erel, 2007). However, both studies did not consider the type of sensitization, the gender, and the age of patients, and the relationship between leptin and clinical parameters.…”

Section: Introductionmentioning

confidence: 95%

Serum Leptin Levels Depend on Allergen Exposure in Patients with Seasonal Allergic Rhinitis

Ciprandi

Amici

Tosca

et al. 2009

Immunological Investigations

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Several studies have outlined a possible relationship between an increased body mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis. There are conflicting data about the role for leptin in allergic rhinitis. Therefore, the aim of the study was to evaluate the serum leptin levels in patients with seasonal allergic rhinitis (SAR), enrolled during and outside the pollen season, and in a group of healthy controls. The study included 137 subjects; 62 symptomatic SAR patients evaluated in season, 41 symptomless SAR patients out season, and 34 normal subjects. All subjects were consecutively evaluated. A skin prick test and blood sampling for assessing serum leptin levels were performed in all subjects. After analysing genders separately, symptomatic male patients had significantly higher levels than symptomless and normal subjects (p = 0.0004 and 0.0031 respectively), symptomatic female patients showed significantly higher levels than normal females (p = 0.0002). This study provides the evidence that leptin serum levels depend on allergen exposure in SAR patients.

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“…However, this association did not persist when clinical data, such as age, parental asthma and active smoking status, were included in the statistical model [105]. Other studies have found no correlation between serum leptin levels and asthma [106,107]. Altogether, evidence of a link between asthma and serum leptin remains unclear and further studies are needed to elucidate whether leptin directly participates in the pathogenesis of asthma, perhaps in certain subsets of this heterogeneous disease, or whether increased serum leptin levels are merely the result of the systemic inflammation that accompanies both asthma and obesity.…”

Section: Role Of Leptin In Inflammatory Lung Diseasesmentioning

confidence: 99%

Leptin as regulator of pulmonary immune responses: Involvement in respiratory diseases

Vernooy

Ubags

Brusselle

et al. 2013

Pulmonary Pharmacology & Therapeutics

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Leptin is an adipocyte-derived hormone, recognized as a critical mediator of the balance between food intake and energy expenditure by signalling through its functional receptor (Ob-Rb) in the hypothalamus. Structurally, leptin belongs to the long-chain helical cytokine family, and is now known to have pleiotropic functions in both innate and adaptive immunity. The presence of the functional leptin receptor in the lung together with evidence of increased airspace leptin levels arising during pulmonary inflammation, suggests an important role for leptin in lung development, respiratory immune responses and eventually pathogenesis of inflammatory respiratory diseases. The purpose of this article is to review our current understanding of leptin and its functional role on the different resident cell types of the lung in health as well as in the context of three major respiratory conditions being chronic obstructive pulmonary disease (COPD), asthma, and pneumonia.

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Serum Leptin Levels and Lipid Profiles in Patients with Allergic Rhinitis and Mild Asthma

Abstract: Our data demonstrate that the serum levels of leptin and lipid profiles on allergic rhinitis and mild asthma were not different than those in controls.

Cited by 19 publications

References 29 publications

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Serum Leptin Levels Depend on Allergen Exposure in Patients with Seasonal Allergic Rhinitis

Leptin as regulator of pulmonary immune responses: Involvement in respiratory diseases

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Serum Leptin Levels and Lipid Profiles in Patients with Allergic Rhinitis and Mild Asthma

Abstract: Our data demonstrate that the serum levels of leptin and lipid profiles on allergic rhinitis and mild asthma were not different than those in controls.

Cited by 19 publications

References 29 publications

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV1 in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV1 in Atopic Asthma

Serum Leptin Levels Depend on Allergen Exposure in Patients with Seasonal Allergic Rhinitis

Leptin as regulator of pulmonary immune responses: Involvement in respiratory diseases

Contact Info

Product

Resources

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Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma