Serum leptin levels and the severity of preeclampsia

Martı́nez-Abundis, Esperanza; González-Ortı́z, Manuel; Pascoe-González, Sara

doi:10.1007/s004040000081

Cited by 53 publications

(43 citation statements)

References 9 publications

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“…This is in agreement with other studies which did not detect any significant differences [18, 34]. We also found similar leptin levels in pregnant women with mild or severe PE in accordance with a previous study [34].…”

Section: Discussionsupporting

confidence: 94%

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

et al. 2011

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OBJECTIVE Conditions resulting in insulin resistance, as well as metabolic, immune and angiogenic perturbations, have been associated with an increased risk of preeclampsia (PE). Our purpose was to assess whether the adipose tissue secreted hormones: adiponectin, which has immune modulating, metabolic and angiogenic properties, and leptin, which reflects overall fat mass, are associated with PE risk. METHODS We performed a case-control design study within a hospital-based cohort of 368 pregnant women (106 with PE and 262 controls; mean age: 26.6 ± 6.8 years; mean gestational age at admission: 38.2 ± 2.8 weeks) between March 2005 and August 2007 at the Hospital of Pennsylvania University. Serum adiponectin and leptin were measured by radioimmunoassay. Statistical analysis of data was performed using simple and multiple regression analyses. RESULTS No significant differences in adiponectin or leptin levels between pre-eclamptic and control pregnant women emerged in univariate analyses (p=0.57 and p=0.15 respectively). Among pre-eclamptic women, there were also no differences in adipokines between those with mild and severe disease. Serum adiponectin and leptin were not associated with higher risk of PE before and after adjustment for maternal age, race, primigravida, smoking status, body mass index at screening, gestational age at admission, history of preeclampsia, chronic hypertension and gestational diabetes (OR: 0.93, 95% C.I.: 0.83–1.04 and OR: 1, 95% C.I.0.97–1.03, respectively). CONCLUSION Maternal serum adiponectin and leptin levels, drawn at the time of PE diagnosis, were not associated with PE.

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Section: Discussionsupporting

confidence: 94%

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

et al. 2011

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“…In normal pregnancy, leptin levels increase, particularly in the second trimester, and decline postpartum [36]. Several studies have found leptin even further upregulated in pre-eclamptic pregnancies (see review by Poston [37]) while others have not been able to prove this association [38, 39] and one study has found that leptin levels were decreased in pre-eclampsia [40]. Some have suggested that upregulation of leptin in pre-eclampsia may cause maternal leptin resistance, which may be a component of insulin resistance, predisposing the onset of endothelial dysfunction [35].…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling of Placentas Affected by Pre-Eclampsia

Hoegh

Borup

Nielsen

et al. 2010

Journal of Biomedicine and Biotechnology

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Several studies point to the placenta as the primary cause of pre-eclampsia. Our objective was to identify placental genes that may contribute to the development of pre-eclampsia. RNA was purified from tissue biopsies from eleven pre-eclamptic placentas and eighteen normal controls. Messenger RNA expression from pooled samples was analysed by microarrays. Verification of the expression of selected genes was performed using real-time PCR. A surprisingly low number of genes (21 out of 15,000) were identified as differentially expressed. Among these were genes not previously associated with pre-eclampsia as bradykinin B1 receptor and a 14-3-3 protein, but also genes that have already been connected with pre-eclampsia, for example, inhibin beta A subunit and leptin. A low number of genes were repeatedly identified as differentially expressed, because they may represent the endpoint of a cascade of events effectuated throughout gestation. They were associated with transcriptional regulation and vasoregulative pathways, along with a number of hypothetical proteins and gene sequences with unknown functions.

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“…Therefore, leptin may be involved in the pathophysiology of the disease. Some authors have, however, reported decreased13 or unchanged14 circulating levels in patients with PE.…”

Section: Introductionmentioning

confidence: 97%

Adiposity and hyperleptinemia during the first trimester among pregnant women with preeclampsia

Yeboah

Ngala

Bawah³

et al. 2017

IJWH

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BackgroundLeptin levels start increasing from the early stages of pregnancy, irrespective of the maternal body mass index. Leptin levels are increased in pregnant women with preeclampsia (PE) and may precede the clinical onset of the disease, with peaks occurring around 28 weeks of gestation. This study was aimed at determining whether serum leptin concentration and body fat percentage are significantly altered during the first trimester in pregnancies that subsequently develop PE and whether such changes are useful in predicting the disease.Materials and methodsThis was a prospective longitudinal study conducted among pregnant women in Ho municipality. A cohort of 314 pregnant women was monitored from the first antenatal visit to delivery period at the Volta Regional Hospital, Ho, Ghana. Maternal serum leptin and lipid profile were analyzed and body fat percentage determined during first trimester. Body mass index was also calculated.ResultsFirst trimester serum leptin level (P<0.0001) and body fat percentage (P<0.0001) were significantly higher in those who developed PE than those who did not; while triglycerides (P=0.8600), total cholesterol (P=0.5620), high-density lipoprotein (P=0.5880), low-density lipoprotein (P=0.4870) and very low-density lipoprotein (P=0.6540) did not show any significant difference between those with PE and those without PE.ConclusionLeptin levels are increased significantly during the first trimester of pregnancy in obese women with PE, and these increases precede the onset of PE.

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Serum leptin levels and the severity of preeclampsia

Cited by 53 publications

References 9 publications

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

Gene Expression Profiling of Placentas Affected by Pre-Eclampsia

Adiposity and hyperleptinemia during the first trimester among pregnant women with preeclampsia

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