Serum Leptin Levels Are Associated with Bone Mass in Nonobese Women

Pasco, JA; Henry, Margaret J.; Kotowicz, Mark A.; Collier, Greg R.; Ball, Madeleine J.; Nicholson, Geoff

doi:10.1210/jc.86.5.1884

Cited by 134 publications

(125 citation statements)

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“…92 Furthermore, a positive correlation between bone mass and serum leptin levels was observed in non-obese women after adjustment for body weight and fat mass. 93 On the other hand, leptin-deficient ob/ob mice have a high bone mass.…”

Section: Bone Mineral Densitymentioning

confidence: 99%

The role of leptin in anorexia nervosa: clinical implications

et al. 2006

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Leptin is a hormone with pleiotropic functions affecting several tissues. Because leptin has a crucial role in the adaptation of an organism to semi-starvation, anorexia nervosa (AN) serves as a model disorder to elucidate the functional implications of hypoleptinaemia; vice versa, several symptoms in patients with this eating disorder are related to the low leptin levels, which are characteristic of acute AN. Weight gain in AN patients can induce relative hyperleptinaemia in comparison to controls matched for body mass index; circulating leptin concentrations in AN patients thus transverse from subnormal to supranormal levels within a few weeks. We review findings on leptin secretion in AN and focus on implications, particularly for the hypothalamus-pituitary-gonadal axis, bone mineral density and physical hyperactivity. Undoubtedly, the elucidation of leptin's function as a trigger of diverse neuroendocrine adaptations to a restricted energy intake has substantially advanced our knowledge of the pathogenesis of distinct symptoms of AN, including amenorrhoea that represents one of the four diagnostic criteria. The fact that hypoleptinaemia can induce hyperactivity in a rat model for AN has led to a series of studies in AN patients, which support the notion that application of leptin to severely hyperactive patients might prove beneficial.

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Section: Bone Mineral Densitymentioning

confidence: 99%

The role of leptin in anorexia nervosa: clinical implications

et al. 2006

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“…Next, we applied the logarithmic scale as described previously (Pasco et al, 2001;Wang et al, 2003;Sakakibara et al, 2004). We then defined the PAI-1 expression score as follows: log e ðthe relative amount of T=the relative amount of NÞ…”

Section: Pai-1 Expression Scorementioning

confidence: 99%

Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer

et al. 2005

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To test the hypothesis that plasminogen activator inhibitor-1 (PAI-1) may serve as a candidate marker for the malignancy of colorectal cancer (CRC), we performed a quantitative RT -PCR for PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological findings in CRC. A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.1970.43) compared to negative ones (0.3570.42) (P ¼ 0.0037) as well as in distant metastasispositive CRCs (3.5071.18) compared to negative ones (0.9970.30). The PAI-1 expression score markedly increased with the tumour stage (P ¼ 0.0063; ANOVA test). Moreover, multivariate analysis revealed the PAI-1 expression score to be a strong and independent prognostic factor for CRC (P ¼ 0.0432). These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC.

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“…They concluded that leptin might decrease bone resorption with the overall effect of increasing bone mass in the human fetus (99). Pasco et al (100) reported that in non-obese women there is a positive correlation between bone mass and serum leptin levels independent of body weight and fat mass. There is also an inverse relationship between serum leptin and a marker of bone formation and BMD in healthy adult men (101).…”

Section: Bone Mineral Density and Bone Markersmentioning

confidence: 99%

Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances

Argente

2002

European Journal of Endocrinology

146

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Anorexia nervosa (AN) is a chronic childhood psychiatric illness that involves a reduction in caloric intake, loss of weight and amenorrhea, either primary or secondary. The diagnostic criteria for AN have been established by the American Psychiatric Association. The prevalence of this disease amongst adolescents and young adults is between 0.5 and 1% and the incidence of new cases per year is approximately 5-10/100 000 between 15 and 19 years of age. A number of endocrine and metabolic disturbances have been described in patients with AN including amenorrhea-oligomenorrhea, delayed puberty, hypothyroidism, hypercortisolism, IGF-I deficiency, electrolyte abnormalities, hypoglycemia and hypophosphatemia, among others. In addition to prolonged amenorrhea, osteopenia and osteoporosis are the most frequent complications leading to clinically relevant fractures and increased fracture risk throughout life. Patients exhibit an alteration in the hypothalamic -pituitary -gonadal axis, which is responsible for the menstrual disorders. The increase in gonadotropin secretion that can be observed after ponderal recuperation suggests that malnutrition could be the most important mechanism involved in the decrease in gonadotropin secretion. The loss of fat tissue as a consequence of nutrient restriction has been associated with hypoleptinemia and abnormal secretion of peptides implicated in food control (neuropeptide Y, melanocortins and corticotropin-releasing factor, among others). A review of the endocrine abnormalities, disturbances in neurotransmitters, as well as a detailed analysis of bone markers and bone mineral density in patients with AN is described.

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Serum Leptin Levels Are Associated with Bone Mass in Nonobese Women

Cited by 134 publications

References 0 publications

The role of leptin in anorexia nervosa: clinical implications

The role of leptin in anorexia nervosa: clinical implications

Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer

Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances

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