Serum Leptin Levels in Dwellers from High Altitude Lands

Woolcott, Orison O.; Castillo, O.; Torres, Javier; Damas, Lucy; Florentini, Alejandro

doi:10.1089/15270290260131975

Cited by 32 publications

(28 citation statements)

References 5 publications

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“…The exercise, weight loss and cold exposure are known to decrease leptin levels (Friedman andHalaas 1998, Havel 2004). The decreased levels of leptin at HA are also reported in HA natives who are genetically adapted (Woolcott et al 2002). In our present study the levels of leptin of lowlanders were found elevated even after prolonged stay at altitude and this indicates that either complete acclimatization is not achieved or there is some sort of leptin insensitivity at HA.…”

Section: Discussionsupporting

confidence: 66%

Ghrelin and leptin levels of sojourners and acclimatized lowlanders at high altitude

Shukla

Singh

Vats

et al. 2005

Nutritional Neuroscience

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The circulatory levels of two appetite regulatory hormones i.e. leptin and ghrelin were estimated in sojourners and acclimatized subjects to investigate their possible role in high altitude (HA) induced anorexia. A group of 30 lowlanders who had never visited HA were inducted to a height of 3600 m by air and after 48 h they were further taken to an altitude of 4300 m by road. Blood samples were collected after 48 h stay at 3600 m and again after 48 h and 7 days of stay at 4300 m during 0700-0730 h. There was a decrease in energy intake (850 kcal/day) of sojourners, which resulted in loss of body weight by 2.12 kg at HA. At an altitude of 4300 m there was a significant increase in leptin over basal levels (54.9%, p < 0.001) at 48 h that persisted even after 7 days of stay at this altitude. Ghrelin levels of sojourners decreased by more than 30% in comparison to basal values at 48 h of ascent to HA. Leptin levels of acclimatized lowlanders were also higher in comparison with control group (acclimatized group 7.6 + 0.6 ng/ml vs. control 5.6 + 0.5 ng/ml, p < 0.01, n = 50).

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Section: Discussionsupporting

confidence: 66%

Ghrelin and leptin levels of sojourners and acclimatized lowlanders at high altitude

Shukla

Singh

Vats

et al. 2005

Nutritional Neuroscience

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“…At HA increase in leptin levels have been reported (Tschop et al 1998), and it was speculated that this increase in leptin levels might be responsible for loss of body weight at HA (Tschop et al 1998). Whereas Woolcott et al (2002) found a lower level of serum leptin in HA natives in comparison to sea level residents. Increase in oxidative stress on HA exposure is well documented (Ilavazhagan et al 2001;Schmidt et al 2002;Jefferson et al 2004;Magalhaes et al 2004).…”

Section: Introductionmentioning

confidence: 77%

“…Norese et al (2002) have reported decreased leptin levels in mice exposed to simulated altitude of 4560 m and conclude that at least in case of rodents leptin is probably not causally implicated in the energy imbalance observed at HA. Lower levels of circulating leptin were observed in HA natives as compared to sea level residents (Woolcott et al 2002;Cabrera de Leon et al 2004). Decrease in circulating leptin levels was also reported by this laboratory (Vats et al 2004) and by Zaccaria et al (2004) on HA exposure.…”

Section: Discussionmentioning

confidence: 94%

High altitude induced anorexia: Effect of changes in leptin and oxidative stress levels

Vats

Singh

et al. 2007

Nutritional Neuroscience

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High altitude (HA) exposure usually leads to a significant weight loss in non-acclimatized humans. Anorexia is believed to be the main cause of this body weight loss. Appetite regulatory peptides, i.e. leptin and neuropeptide Y play a key role in food intake and energy homeostasis. Recent studies suggests increased oxidative stress during HA exposure. In present study effect of HA exposure on levels of leptin and NPY was evaluated along with N-acetyl cysteine (NAC) and vitamin E supplementation in relation to food intake and body weight changes. The study was conducted on 30 healthy male volunteers (age 19-29 years). Subjects were divided randomly into three groups of 10 each. Group 1 (placebo) supplemented with 400 mg of calcium gluconate, group 2 and 3 were supplemented with 400 mg of NAC and 400 mg vitamin E, respectively per day. The study was conducted at low altitude (320 m, Phase I), at HA 3600 m (Phase II) and at an altitude of 4580 m (Phase III). On HA exposure significant reduction in plasma leptin levels was observed in all the groups on day 2 (Phase II) along with decrease in food intake and reduction in body weight. Statistically significant increase in blood malondialdehyde (MDA) levels was seen in all the groups on HA exposure (Phase II, Day 2), but the maximum increase was in case of placebo group (65.1%) on day 2 (Phase II) in comparison to low altitude values. The decrease in energy intake was almost same in all the groups indicating that antioxidant supplementation did not provide any protection against HA anorexia. From the study, it may be concluded that leptin and oxidative stress possibly are not the key players for HA anorexia.

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“…Tschöp et al (1998) reported elevated serum leptin levels in human subjects at high altitude, and this was considered the mechanism of high altitude anorexia. However, results of subsequent studies on animal models and natives of different altitude appear to be contradictory (Norese et al, 2002;Woolcott et al, 2002).…”

Section: Luanne Freermentioning

confidence: 99%