Serum Leptin Levels in Rheumatoid Arthritis and Relationship with Disease Activity

Günaydın, Rezzan; Kaya, Taciser; Atay, Ayşenur; Ölmez, Neşe; Hür, Aysel; Köseoğlu, Mehmet

doi:10.1097/01.smj.0000240625.27772.79

Cited by 48 publications

(30 citation statements)

References 34 publications

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“…Most of the previous studies showed the serum levels of several adipokines in only around 50 patients (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). They indicated that the serum resistin (12,13,25), leptin (14-16, 23, 25) and adiponectin (14,(22)(23)(24)(25) levels are higher in RA patients than in healthy controls, while negative results (14,(17)(18)(19)(20)24) were also reported.…”

Section: Discussionmentioning

confidence: 92%

Elevated Serum Levels of Resistin, Leptin, and Adiponectin are Associated with C-reactive Protein and also Other Clinical Conditions in Rheumatoid Arthritis

et al. 2011

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Objective Body fat is an important source of hormones and cytokines (adipokines) that not only regulate the energy balance, but also regulate the inflammatory and immune responses. This study investigated the association of clinical conditions with serum levels of adipokines in patients with rheumatoid arthritis. Methods Serum levels of resistin, leptin, and adiponectin were measured by enzyme-linked immunosorbent assay in 141 patients (110 women) who fulfilled the 1987 revised criteria of the American Rheumatism Association for the diagnosis of rheumatoid arthritis and in 146 normal controls (124 women). Then the correlations between adipokine levels and clinical parameters were evaluated. Results The serum resistin level did not differ between the patients and controls. However, serum leptin levels were significantly higher in male and female rheumatoid arthritis patients than in the corresponding controls, while the serum adiponectin level was significantly higher in female patients than in female controls. Multivariate analysis revealed that predictors of an elevated resistin level were female sex and Creactive protein (CRP), while the leptin level was related to the body mass index and CRP. Predictors of an elevated adiponectin level were the use of prednisolone and CRP, however, CRP was negatively associated with adiponectin in patients with rheumatoid arthritis. Conclusion The serum levels of resistin and leptin were positively associated with CRP level in patients with rheumatoid arthritis, suggesting that these adipokines may act as pro-inflammatory cytokines in this disease. The serum adiponectin level was elevated in the patients, however, it was negatively associated with CRP level. In addition, the serum levels of resistin, leptin, and adiponectin were also associated with female sex, BMI and the use of prednisolone, respectively.

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Section: Discussionmentioning

confidence: 92%

Elevated Serum Levels of Resistin, Leptin, and Adiponectin are Associated with C-reactive Protein and also Other Clinical Conditions in Rheumatoid Arthritis

et al. 2011

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“…However, serum levels of leptin seem to be higher than the levels in synovial fluid (44). Although leptin is positively correlated with body fat content (46,50), a correlation between plasma concentration of leptin, body mass index (BMI) (46)(47)(48)50,51), and markers of inflammation is still debated (47)(48)(49)(50)(51)(52). An interesting feature is the finding that serum levels of leptin are higher in active RA than in less-active RA (51), and differences in leptin levels between plasma and synovial fluid were greater in nonerosive than in erosive arthritis (44).…”

Section: Adiponectin In Ramentioning

confidence: 91%

Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases?

Neumann

Frommer

Vasile

et al. 2011

Arthritis & Rheumatism

100

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“…In short, there are several potential explanations for these differing results among these studies: first, the relatively small sample size may not precisely represent the larger patients; secondly, the baseline characteristics such as disease duration, age, race and BMI can be inconsistent, which may affect the expression level of leptin; thirdly, patients with other co-existing autoimmune diseases cannot be excluded from studies, which could be potential confounding factors; and fourthly, different measurement methods of leptin levels, such as radioimmunoassay [20,37,40,100] and enzyme-linked immunosorbent assay (ELISA), may also cause deviation [8,23,30]. In addition, discrepancies in leptin levels in RA patients could be due to different treatments that intervene with the endocrine system, which usually complicates human experimental researches.…”

Section: Leptin Levels In Serum Synovial Fluid and Synovial Tissue Amentioning

confidence: 99%

Emerging role of leptin in rheumatoid arthritis

Tian

Liang

Wang

et al. 2014

Clinical and Experimental Immunology

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SummaryNumerous studies have suggested the importance of leptin against autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS) and psoriasis. To summarize our current understanding of the role of leptin in inflammatory responses and rheumatoid arthritis (RA), a systematic review was conducted to assess the discrepancy of leptin in RA and its effect on immunity according to different studies. Recently, emerging data have indicated that leptin is involved in the pathological function of RA, which is common in autoimmune disorders. This review discusses the possible consequences of leptin levels in RA. Blocking the key signal pathways of leptin and inhibiting the leptin activity-like leptin antagonist may be a promising way for potential therapeutic treatment of RA at risk of detrimental effects. However, leptin was increased in patients with RA and may also regulate joint damage. Thus, more understanding of the mechanism of leptin in RA would be advantageous in the future.

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Serum Leptin Levels in Rheumatoid Arthritis and Relationship with Disease Activity

Cited by 48 publications

References 34 publications

Elevated Serum Levels of Resistin, Leptin, and Adiponectin are Associated with C-reactive Protein and also Other Clinical Conditions in Rheumatoid Arthritis

Elevated Serum Levels of Resistin, Leptin, and Adiponectin are Associated with C-reactive Protein and also Other Clinical Conditions in Rheumatoid Arthritis

Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases?

Emerging role of leptin in rheumatoid arthritis

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