Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion

Lage, Mary; García‐Mayor, Ricardo V.; Tomé, María Ausencia; Cordido, Fernando; Valle-Inclán, Fernando; Considine, Robert V.; José, F.; Diéguez, Carlos; Casanueva, Felipe F.

doi:10.1046/j.1365-2265.1999.00637.x

Cited by 94 publications

(81 citation statements)

References 41 publications

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“…First trimester cytotrophoblasts also contain leptin mRNA and protein and our studies suggest that placental leptin content increases from first to third trimester . This finding is in agreement with the gestational increase in leptin measured in the maternal circulation (Hardie et al, 1997;Lage et al, 1999). In addition, the leptin gene is also expressed in the villous vascular endothelial cells in direct contact with the fetal blood .…”

Section: Localizationsupporting

confidence: 80%

“…During human pregnancy, circulating maternal concentrations of leptin increase to maximal values in the second trimester, plateau in the third trimester and fall to below pre-pregnancy concentrations around birth (Hardie et al, 1997;Lage et al, 1999). Although maternal fat deposition increases during pregnancy, changes in maternal body mass index appear not to correlate with the gestational increase in circulating leptin.…”

Section: Functionmentioning

confidence: 91%

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Placental leptin

Ashworth¹,

Hoggard²,

Thomas³

et al. 2000

Reviews of Reproduction

175

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Section: Localizationsupporting

confidence: 80%

Section: Functionmentioning

confidence: 91%

Placental leptin

Ashworth¹,

Hoggard²,

Thomas³

et al. 2000

Reviews of Reproduction

175

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“…As in many other studies (Butte et al, 1997;Lage et al, 1999;Sattar et al, 1998;Schrubing et al, 1998;Tamura et al, 1998), plasma leptin concentrations were signi®cantly higher in pregnant women when compared to non-pregnant women. Our study further indicated that this pregnancyrelated increase in leptin concentration starts within the ®rst 2 ± 3 weeks after conception.…”

Section: Discussionsupporting

confidence: 83%

Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation

Rump

Otto

Hornstra³

2001

Eur J Clin Nutr

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Background: The n-3 fatty acid status changes during pregnancy and lactation. Plasma leptin concentrations and gene expression have been related to n-3 fatty acids. Objective: To investigate the relation between plasma leptin concentration and the docosahexaenoic acid (22:6n-3) content of plasma phospholipids during early pregnancy and the postpartum period. Design: Leptin (radioimmunoassay) and the phospholipid fatty acid pro®le (capillary gas-liquid chromatography) were measured in plasma of women during two independent longitudinal observational studies. Dietary intake of n-3 fatty acids was also determined. Results: Within the ®rst 10 weeks after the last menstrual period, an almost parallel increase in leptin concentration and the 22:6n-3 content (mgal and % wtawt) of plasma phospholipids was seen (study 1, n 21). During the postpartum period (study 2, n 57), leptin levels decreased quickly, preceding the changes in 22:6n-3 concentrations. During both studies, leptin concentrations did not consistently relate to dietary intake of n-3 fatty acids or to 22:6n-3 concentrations in plasma phospholipids. Before and during early pregnancy (study 1), signi®cant positive associations between leptin levels and the total amount of phospholipid-associated fatty acids were found. No such association was seen during late pregnancy or the postpartum period (study 2). The postpartum decrease in leptin levels did not differ between lactating and non-lactating women. Conclusions: Not the 22:6n-3 content, but the total amount of phospholipid-associated fatty acids was related to plasma leptin concentration, before and during early pregnancy but not during late pregnancy and the postpartum period. Sponsorship: Dutch Organization for Scienti®c Research (NWO, grant no. 904 62 186).

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“…(21) reported that leptin values increased significantly from the first to the second trimester, decreased slightly in the third trimester and declined markedly 4-6 weeks after delivery. Abnormally low serum leptin levels were observed in women suffering spontaneous abortion in the first trimester of pregnancy (29). In our study, serum leptin levels were similar in both groups.…”

Section: Discussionsupporting

confidence: 71%

The effects of GnRH analogs on serum and follicular fluid leptin levels and pregnancy outcomes in short protocols of assisted reproductive technology

Ergenoğlu

Yeniel

Akdoğan

et al. 2012

J Turkish German Gynecol Assoc

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Objective:To determine serum and follicular leptin levels in patients using gonadotropin releasing hormone agonist and antagonist in Assisted Reproductive Technology short protocol cycles and to evaluate pregnancy outcomes. Material and Methods:Patients randomly selected to join assisted reproductive technology cycles during February 2004-July 2004 were enrolled in this study. Group 1 consisted of 21 patients receiving r FSH+ GnRH agonists, whereas Group 2 consisted of 34 patients who received r FSH +GnRH antagonists. During the ovulation induction period 5 serum samples were collected (induction day 1, day 3 or antagonist starting day, human chorionic hormone day, oocyte pickup day, and twelfth day of embryo transfer). Follicular fluid samples were collected to be evaluated for leptin, estradiol, prolactin and luteinizing hormone.Results: There was no difference in age, basal FSH, basal LH, and basal E2 between groups. Serum leptin levels were similar in both groups. Also, when each group's serum leptin levels were evaluated according to the presence of pregnancy, there was no significant difference in both groups. When follicle leptin levels were evaluated according to the existence of pregnancy, in both groups the follicle leptin levels were lower in pregnant participants but this difference was not statistically significant. When obesity is defined as body mass index over 26.5, there is a correlation between obesity and leptin levels in Group 2. Conclusion:Our results have shown that both agonists and antagonists have similar efficacy and effect in poor responder women. Leptin levels in either groups, whether pregnant or non-pregnant were not statistically different. This result shows the need for more studies on leptin in infertility. (J Turkish-German Gynecol Assoc 2012; 13: 91-7)Key words: GnRH agonist, GnRH antagonist, ART, leptin, prolactin Received: 10 January, 2012 Accepted: 19 January, 2012 Amaç: Yardımcı Üreme Teknikleri (YÜT) ile kısa protokol uygulanan sikluslarda gonadotropin salgılatıcı hormon (GnRH) agonist ve antagonist uygulanan olgularda serum ve foliküler leptin seviyelerinin belirlenmesi ve gebelik sonuçlarının değerlendirilmesidir. Bulgular: Gruplar arasında yaş, bazal FSH, bazal LH ve bazal E2 açı-sından fark izlenmedi. Serum leptin düzeyleri her iki grupta benzer idi. Ayrıca her grupta gebelik varlığına göre serum leptin seviyeleri değer-lendirildiğinde gruplar arasında fark izlenmedi. Folikül leptin seviyeleri gebelik mevcudiyetine göre değerlendirildiğinde her iki grupta da folikül leptin seviyeleri gebe olgularda daha düşük olmasına rağmen bu fark istatistiksel olarak anlamlı değildi. Obesite vücut kitle indeks değerinin 26.5 üzerinde olması olarak tanımlandığında Grup 2'de leptin seviyeleri ile obesite arasında korelasyon mevcut idi. Gereç ve Yöntemler:Sonuç: Sonuçlarımız düşük cevaplı olgularda hem agonistlerin hem de antagonistlerin benzer etkinlik ve etkiye sahip olduğunu göstermiş-tir. Her iki grupta da leptin seviyeleri gebe olanlarda veya olmayanlarda istatistiksel olarak...

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Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion

Cited by 94 publications

References 41 publications

Placental leptin

Placental leptin

Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation

The effects of GnRH analogs on serum and follicular fluid leptin levels and pregnancy outcomes in short protocols of assisted reproductive technology

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