Serum level of fetuin B is associated with osteoporosis: a 4-year prospective study in China

Xu, Zhonghua; He, Jin; Zhang, Xing; Xie, Hui; Zhou, Zhengyuan; Sun, Yawen; Luo, Xiang

doi:10.25011/cim.v41i1.29460

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…It is increased in patients with type 2 diabetes and impairs insulin sensitivity in myotubes and hepatocytes ( 76 , 77 ). A 4-year prospective study in China showed serum level of fetuin-B is associated with osteoporosis ( 78 ). Nevertheless, research on the role of fetuin-B in bone metabolism remains limited, both in vivo and in vitro .…”

Section: Hepatokines: From Liver To Bonementioning

confidence: 99%

The roles of hepatokine and osteokine in liver-bone crosstalk: Advance in basic and clinical aspects

et al. 2023

Front. Endocrinol.

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Both the liver and bone are important secretory organs in the endocrine system. By secreting organ factors (hepatokines), the liver regulates the activity of other organs. Similarly, bone-derived factors, osteokines, are created during bone metabolism and act in an endocrine manner. Generally, the dysregulation of hepatokines is frequently accompanied by changes in bone mass, and osteokines can also disrupt liver metabolism. The crosstalk between the liver and bone, particularly the function and mechanism of hepatokines and osteokines, has increasingly gained notoriety as a topic of interest in recent years. Here, based on preclinical and clinical evidence, we summarize the potential roles of hepatokines and osteokines in liver-bone interaction, discuss the current shortcomings and contradictions, and make recommendations for future research.

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Section: Hepatokines: From Liver To Bonementioning

confidence: 99%