Serum level of interleukin-6 (IL-6) and N-terminal propeptide of procollagen type I (PINP) in patients with liver diseases

Gudowska-Sawczuk, Monika; Wrona, Alicja; Gruszewska, Ewa; Cylwik, Bogdan; Panasiuk, Anatol; Flisiak, Robert; Chrostek, Lech

doi:10.1080/00365513.2017.1420217

Cited by 17 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Plasma and/or broncho-alveolar levels of IL-6 have been identified as early biomarkers of lung injury [7]. IL-6 acts on hepatocytes to induce expression of CRP as a part of the acute phase response and may also play a central role for the development and progression of liver disease [9].…”

mentioning

confidence: 99%

COVID-19 and the role of chronic inflammation in patients with obesity

Chiappetta¹,

Sharma

Bottino³

et al. 2020

Int J Obes

213

166

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in people with obesity, is associated with the development of atherosclerosis, type 2 diabetes, and hypertension, well known comorbidities that adversely affect the outcomes of patients with COVID-19. Risk stratification based on the Edmonton Obesity Staging System (EOSS), which classifies obesity based on the presence of medical, mental, and/or functional complications rather than on body mass index (BMI), has been shown to be a better predictor of all-cause mortality and it may well be that EOSS stages may better describe the risk of hyperinflammation in patients with COVID-19 infection. Analyzing a group of metabolic ill patients with obesity (EOSS 2 and 3), we found an increased interleukin-6 and linear regression analysis showed a positive correlation with C-reactive protein (CRP) (p = 0.014) and waist-to-hip-ratio (WHR) (p = 0.031). Physicians should be aware of these findings in patients with COVID-19 infection. Early identification of possible hyperinflammation could be fundamental and should guide decision making regarding hospitalization, early respiratory support, and therapy with immunosuppression to improve mortality.

show abstract

mentioning

confidence: 99%

COVID-19 and the role of chronic inflammation in patients with obesity

Chiappetta¹,

Sharma

Bottino³

et al. 2020

Int J Obes

213

166

View full text Add to dashboard Cite

show abstract

“…In extremely obese patients with an average body mass index of 44 kg/m 2 , liver biopsy confirmed that the increased stages of fibrosis were independently associated with higher levels of P1NP (29). The P1NP has also been reported to be related to liver fibrosis in other chronic hepatic diseases (10,30,31). In primary biliary cirrhosis patients, P1NP levels were higher than in controls (30).…”

Section: Discussionmentioning

confidence: 76%

“…In primary biliary cirrhosis patients, P1NP levels were higher than in controls (30). In alcoholic cirrhosis patients, the mean serum P1NP concentration was significantly higher than in the control group and appeared to vary depending on the severity of the liver damage (i.e., the concentration of P1NP was significantly higher in Child-Pugh class C than in class A) (10). The concentration of P1NP in the femoral artery blood was also significantly higher in patients with alcoholic cirrhosis than in patients with normal liver function (31).…”

Section: Discussionmentioning

confidence: 83%

“…Moreover, a relatively small sample study in postmenopausal women with diabetes found that the presence of NAFLD and significant fibrosis was significantly associated with lower bone turnover (9). Bone turnover markers, such as β-C-terminal telopeptide (β-CTX), N-MID osteocalcin, and procollagen type 1 N-peptide (P1NP), were reported to be associated with chronic liver injury, inflammation, and fibrosis (10)(11)(12). However, to the best of our knowledge, there are limited studies with a large sample size that have provided information on the association between advanced NAFLD status (NASH and significant fibrosis) and bone turnover markers in diabetic patients of both genders.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bone Turnover Markers and Probable Advanced Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Men and Postmenopausal Women With Type 2 Diabetes

Wang

Chen

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

Objective: Type 2 diabetic patients have a higher incidence of nonalcoholic steatohepatitis (NASH) and advanced stages of fibrosis, and nonalcoholic fatty liver disease (NAFLD) is associated with impaired bone health. We aimed to investigate whether bone turnover is associated with the probable presence of NASH and fibrosis.Methods: In total, 4,937 diabetic participants from Shanghai, China were enrolled in 2018. Subjects with NAFLD were categorized into simple NAFLD and probable NASH groups based on the presence of a metabolic syndrome. The NAFLD fibrosis score was used to identify patients with a higher likelihood of advanced fibrosis.Results: In postmenopausal women, large N-mid fragment of osteocalcin (N-MID osteocalcin) was negatively associated with probable NASH (P for trend < 0.001). β-C-terminal cross-linked telopeptides of type I collagen (β-CTX) and procollagen type I N-terminal propeptide (P1NP) were positively associated with the probable presence of significant fibrosis in postmenopausal women (P for trend 0.015 and <0.001). However, in men, N-MID osteocalcin and β-CTX were negatively associated with the probable presence of significant fibrosis (P for trend 0.029 and 0.027).Conclusions: Significant associations among N-MID osteocalcin, β-CTX and P1NP, and probable advanced NAFLD were observed. Further prospective and animal studies are warranted to understand the causal relationship and underlying mechanism.

show abstract

“…However, we found no evidence that previous studies investigated the effect of osteopontin or FGF18 on Cdx2 or Pdx1 expression. High serum concentrations of IL‐6 were reported in experimental fibrosis/cirrhosis models and in patients with liver cirrhosis of different etiologies . IL‐6, a multifunctional cytokine synthesized by fibroblasts, monocytes, Kupffer cells, T cells, and endothelial cells, can induce up‐regulation of Cdx2 in epithelial cells .…”

Section: Discussionmentioning

confidence: 99%

Biliary Obstruction Promotes Multilineage Differentiation of Hepatic Stem Cells

et al. 2019

View full text Add to dashboard Cite

Because of their high regenerative potential, stem cells are an ideal resource for development of therapies that replace injured tissue mass and restore function in patients with end‐stage liver diseases. Using a rat model of bile duct ligation (BDL) and biliary fibrosis, we investigated cell engraftment, liver repopulation, and ectopic tissue formation after intrasplenic transplantation of epithelial stem/progenitor cells. Fetal liver cells were infused into the spleens of Fisher 344 rats with progressing biliary fibrosis induced by common BDL or rats without BDL. Cell delivery was well tolerated. After migration to the liver, donor‐derived stem/progenitor cells engrafted, differentiated into hepatocytes and cholangiocytes, and formed large cell clusters at 2 months in BDL rats but not controls. Substantial numbers of donor cells were also detected at the splenic injection site where they generated hepatic and nonhepatic tissue. Transplanted cells differentiated into phenotypes other than hepato/cholangiocytic cells only in rats that underwent BDL. Quantitative reverse‐transcription polymerase chain reaction analyses demonstrated marked up‐regulation of tissue‐specific genes of nonhepatic endodermal lineages (e.g., caudal type homeobox 2 [Cdx2], pancreatic and duodenal homeobox 1 [Pdx1], keratin 13 [CK‐13]), confirmed by immunohistochemistry. Conclusion: BDL and its induced fibrosis promote liver repopulation by ectopically transplanted fetal liver‐derived cells. These cell fractions contain multipotent stem cells that colonize the spleen of BDL rats and differentiate into multiple gastrointestinal tissues, including liver, pancreas, intestine, and esophagus. The splenic microenvironment, therefore, represents an ideal niche to assess the differentiation of these stem cells, while BDL provides a stimulus that induces their differentiation.

show abstract

Serum level of interleukin-6 (IL-6) and N-terminal propeptide of procollagen type I (PINP) in patients with liver diseases

Cited by 17 publications

References 20 publications

COVID-19 and the role of chronic inflammation in patients with obesity

COVID-19 and the role of chronic inflammation in patients with obesity

Bone Turnover Markers and Probable Advanced Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Men and Postmenopausal Women With Type 2 Diabetes

Biliary Obstruction Promotes Multilineage Differentiation of Hepatic Stem Cells

Contact Info

Product

Resources

About