Serum Level of MMP-3 in Patients with Oral Squamous Cell Carcinoma - Lack of Association with Clinico-pathological Features

Andisheh-Tadbir, Azadeh; Purshahidi, Sara; Ebrahimi, Hooman; Khademi, Bijan; Malekzadeh, Mahzad; Mardani, Maryam; Taghva, Masumeh; Sardari, Yasaman

doi:10.7314/apjcp.2012.13.9.4545

Cited by 20 publications

(20 citation statements)

References 26 publications

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“…These findings, in conjunction with our observation, suggests an undefined role of nuclear MMP-3 in the development of prostate cancer. In addition, the elevation of MMP-3 serum levels in cancer patients but the lack of a significant association with clinicopathological features, as demonstrated by the present and earlier studies 37 – 39 , implies that serum MMP-3 might be a useful diagnostic tumor marker albeit one that cannot be used to prognosticate.…”

Section: Discussionsupporting

confidence: 52%

Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Hsieh

Liu

Chen

et al. 2017

Sci Rep

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Studies on the aberrant control of extracellular matrices (ECMs) have mainly focused on the role of malignant cells but less on that of stromal fibroblasts during cancer development. Herein, by using paired normal and prostate cancer-associated stromal fibroblasts (CAFs) derived from a coculture cell model and clinical patient samples, we demonstrated that although CAFs promoted prostate cancer growth, matrix metalloproteinase-3 (MMP-3) was lower in CAFs but elevated in prostate cancer cells relative to their normal counterparts. Furthermore, hydrogen peroxide was characterized as the central modulator for altered MMP-3 expression in prostate cancer cells and CAFs, but through different regulatory mechanisms. Treatment of CAFs but not prostate cancer cells with hydrogen peroxide directly inhibited mmp-3 promoter activity with concomitant nuclear translocation of nuclear factor-κB (NF-κB), indicating that NF-κB is the downstream pathway for the transcriptional repression of MMP-3 in CAFs. Hydrogen peroxide reduced thrombospondin 2 (an MMP-3 suppressor) expression in prostate cancer cells by upregulating microRNA-128. To the best of our knowledge, this is the first study to demonstrate the crucial role of reactive oxygen species in the switching expression of MMP-3 in stromal fibroblasts and prostate cancer cells during tumor progression, clarifying how the tumor microenvironment modulates ECM homeostasis control.

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Section: Discussionsupporting

confidence: 52%

Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Hsieh

Liu

Chen

et al. 2017

Sci Rep

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“…Using cut-off values of 18 ng/mL and 1.99 μ g/mL for MMP-3 and COMP, respectively (based on the mean values for the healthy control subjects +2 standard deviations), the mean MMP-3 and COMP values for the control groups compared favourably with previous studies of 46 and 291 healthy controls respectively [32, 33]. The respective frequencies of elevated MMP-3 and COMP levels for the RA patients were 56.25% and 34.6% (Table 1).…”

Section: Resultsmentioning

confidence: 56%

Serum Matrix Metalloproteinase-3 in Comparison with Acute Phase Proteins as a Marker of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis

Ally

Hodkinson

Meyer

et al. 2013

Mediators of Inflammation

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Matrix metalloproteinase-3 (MMP-3) is involved in the immunopathogenesis of rheumatoid arthritis (RA), but little is known about its relationship to genetic susceptibility and biomarkers of disease activity, especially acute phase reactants in early RA. MMP-3 was measured by ELISA in serum samples of 128 disease-modifying, drug-naïve patients and analysed in relation to shared epitope genotype, a range of circulating chemokines/cytokines, acute phase reactants, autoantibodies, cartilage oligomeric protein (COMP), and the simplified disease activity index (SDAI). MMP-3 was elevated >1.86 ng/ml in 56.25% of patients (P < 0.0001), correlated with several biomarkers, notably IL-8, IL-6, IFN γ, VEGF and COMP (r values = 0.22–0.33, P < 0.014–0.0001) and with CRP and SAA levels (r = 0.40 and 0.41, resp., P < 0.0000) and SDAI (r = 0.29, P < 0.0001), but not with erosions or nodulosis. However, the correlations of CRP and SAA with SDAI were stronger (respective values of 0.63 and 0.54, P < 0.001 for both). COMP correlated with smoking, RF, and MMP-3. MMP-3 is significantly associated with disease activity, inflammatory mediators and cartilage breakdown, making it a potential biomarker of disease severity, but seemingly less useful than CRP and SAA as a biomarker of disease activity in early RA.

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“…Tadbir et al ( 34 ), analysed serum MMP-3 level in OSCC patients. Their results showed that serum MMP-3 level in OSCC patients was significantly higher than healthy controls but they couldn`t correlate serum MMP-3 concentration with the clinicopathological.…”

Section: Discussionmentioning

confidence: 99%

The role of serum biomarkers in the diagnosis and prognosis of oral cancer: A systematic review

et al. 2016

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IntroductionOral cancer is one of the causes of major morbidity and mortality in the world although incidence varies in the different geographical locations and races. Advances in molecular biology and cancer research have allowed elucidating serum biomarkers to improve diagnostic methods. The aim of this article systematic review is to highlight the utility and clinical value of serum biomarkers in the diagnosis and prognosis of oral cancer.Material and MethodsA systematic literature review using PubMed (MEDLINE databases) revealed a total of 140 articles related to this topic. Of those articles, 29 were included in the final review. We included articles published in English in the last five years, developed in human as cases and controls studies, retrospective or prospective studies and specific studies that analyzed a certain biomarker in serum.ResultsAll of the studies include in this systematic review found significant differences in patients. Of those articles included, 2 used biomarkers to determinate cancerous phenotype, 11 mentioned their results were associated with worse prognosis and overall survival, 4 correlated biomarker concentration to clinical stages, 4 concluded it could be a helpful in diagnosis and 8 studies did not find a clear utility of the analysed biomarker. Due to differences in the presentation of data, meta-analysis was not possible.ConclusionsBiomarker use for diagnosis and prognosis is supported by clinical and scientific evidence is relevant. Nevertheless, after selecting a certain biomarker, monitoring protocols should be established in oral and maxillofacial surgeons teams so as we have a correct understanding of biological values. Key words:Serum biomarkers, oral cancer, diagnosis, prognosis.

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Serum Level of MMP-3 in Patients with Oral Squamous Cell Carcinoma - Lack of Association with Clinico-pathological Features

Cited by 20 publications

References 26 publications

Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Serum Matrix Metalloproteinase-3 in Comparison with Acute Phase Proteins as a Marker of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis

The role of serum biomarkers in the diagnosis and prognosis of oral cancer: A systematic review

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