Serum Level of the Phosphaturic Factor FGF23 Is Associated with Abdominal Aortic Calcification in Men: The STRAMBO Study

Schoppet, Michael; Hofbauer, Lorenz C.; Brinskelle-Schmal, Natascha; Varennes, Annie; Goudable, J.; Richard, Michel; Hawa, Gerhard; Chapurlat, Roland; Szulc, Paweł

doi:10.1210/jc.2011-2836

Cited by 80 publications

(66 citation statements)

References 63 publications

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“…37 An inverse relationship between CAC prevalence and BMD by DXA has also been shown in patients who are osteoporotic with normal kidney function and patients with HIV or metabolic syndrome. [38][39][40][41] In this study, a positive correlation was found between CAC SQRVand FGF23, which is in agreement with several published reports on vascular calcifications [42][43][44][45][46] but not in keeping with another report on patients with CKD not on dialysis. 29 Baseline FGF23 remained an independent predictor for baseline CAC after multivariable adjustment for age, CAD, diabetes, dialysis vintage, and BMD.…”

Section: Discussionsupporting

confidence: 92%

High Parathyroid Hormone Level and Osteoporosis Predict Progression of Coronary Artery Calcification in Patients on Dialysis

Malluche¹,

Blomquist²,

Monier‐Faugere³

et al. 2015

Journal of the American Society of Nephrology

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Coronary artery calcifications (CACs) are observed in most patients with CKD on dialysis (CKD-5D). CACs frequently progress and are associated with increased risk for cardiovascular events, the major cause of death in these patients. A link between bone and vascular calcification has been shown. This prospective study was designed to identify noninvasive tests for predicting CAC progression, including measurements of bone mineral density (BMD) and novel bone markers in adult patients with CKD-5D. At baseline and after 1 year, patients underwent routine blood tests and measurement of CAC, BMD, and novel serum bone markers. A total of 213 patients received baseline measurements, of whom about 80% had measurable CAC and almost 50% had CAC Agatston scores.400, conferring high risk for cardiovascular events. Independent positive predictors of baseline CAC included coronary artery disease, diabetes, dialysis vintage, fibroblast growth factor-23 concentration, and age, whereas BMD of the spine measured by quantitative computed tomography was an inverse predictor. Hypertension, HDL level, and smoking were not baseline predictors in these patients. Three quarters of 122 patients completing the study had CAC increases at 1 year. Independent risk factors for CAC progression were age, baseline total or whole parathyroid hormone level greater than nine times the normal value, and osteoporosis by t scores. Our results confirm a role for bone in CKD-associated CAC prevalence and progression.

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Section: Discussionsupporting

confidence: 92%

High Parathyroid Hormone Level and Osteoporosis Predict Progression of Coronary Artery Calcification in Patients on Dialysis

Malluche¹,

Blomquist²,

Monier‐Faugere³

et al. 2015

Journal of the American Society of Nephrology

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“…FGF-23 is a phosphaturic hormone that regulates mineral homeostasis (7,24). Recent studies have suggested that FGF-23 is associated with incident cardiovascular disease, left ventricular hypertrophy (LVH), heart failure, progression of kidney disease, and mortality (6,7,25).…”

Section: Discussionmentioning

confidence: 99%

Fibroblast Growth Factor-23 and the Long-Term Risk of Hospital-Associated AKI among Community-Dwelling Older Individuals

Brown¹,

Katz²,

Ix³

et al. 2014

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives AKI occurs frequently in older persons. Elevated circulating fibroblast growth factor-23 (FGF-23), a known marker of impaired mineral metabolism, may also reflect tubular dysfunction and risk of AKI. This study evaluated FGF-23 as well as traditional markers of kidney disease, namely urine albumin-tocreatinine ratio (UACR) and creatinine-cystatin C estimated GFR (eGFR CrCyC ), as risk factors for AKI in elderly individuals.Design, setting, participants, & measurements Plasma FGF-23, UACR, and eGFR CrCyC were measured in 3241 community-dwelling elderly individuals in the Cardiovascular Health Study. Hospitalization for AKI was defined by International Classification of Diseases, Ninth Revision, Clinical Modification codes. Associations of each biomarker with AKI were evaluated using Cox proportional hazards models adjusted for demographics, cardiovascular risk factors, and biomarkers of kidney function.Results The mean participant age was 78 years; 60% of participants were women and 16% were African Compared with the highest quartile, the lowest quartile of eGFR CrCyC (,57 ml/min per 1.73 m 2 ) was associated with AKI with an HR of 2.15 (95% CI, 1.21 to 3.82).Conclusions FGF-23 adjusted for albuminuria, cardiovascular disease risk factors, and baseline eGFR is independently associated with a higher risk of AKI hospitalizations in community-dwelling elderly individuals. Further studies to understand the nature of this association are warranted.

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“…FGF-23 has recently emerged as a major phosphaturic hormone, and clinical trials demonstrate an association between FGF-23 levels and vascular calcification in both healthy and CKD populations (18,99). However, the addition of FGF-23 to cultured human VSMC did not increase the calcium content of the cells in either control or high-phosphate media (101).…”

Section: Risk Factors For Vascular Calcification In Ckdmentioning

confidence: 99%

A current understanding of vascular calcification in CKD

Paloian

Giachelli

2014

American Journal of Physiology-Renal Physiology

279

264

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Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have significant cardiovascular morbidity and mortality that is in part due to the development of vascular calcification. Vascular calcification is an active, highly regulated process that shares many similarities with normal bone formation. New discoveries related to extracellular vesicles, microRNAs, and calciprotein particles continue to reveal the mechanisms that are involved in the initiation and progression of vascular calcification in CKD. Further innovations in these fields are critical for the development of biomarkers and therapeutic options for patients with CKD and ESRD.

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Serum Level of the Phosphaturic Factor FGF23 Is Associated with Abdominal Aortic Calcification in Men: The STRAMBO Study

Abstract: In healthy older men, circulating FGF23 is associated with parameters of mineral metabolism, including bone metabolism-regulating cytokines, and with severe AAC independent of traditional risk factors.

Cited by 80 publications

References 63 publications

High Parathyroid Hormone Level and Osteoporosis Predict Progression of Coronary Artery Calcification in Patients on Dialysis

High Parathyroid Hormone Level and Osteoporosis Predict Progression of Coronary Artery Calcification in Patients on Dialysis

Fibroblast Growth Factor-23 and the Long-Term Risk of Hospital-Associated AKI among Community-Dwelling Older Individuals

A current understanding of vascular calcification in CKD

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