Serum Level of Thyroid Hormones in Patients with Chronic Hepatitis C Virus Infection

Elfeki, Mohamed A.; Abdalla, Nilly Helmy; Atta, Mohamed I.; Ibrahim, Ahmed

doi:10.4236/ojemd.2016.63017

Cited by 14 publications

(16 citation statements)

References 15 publications

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“…The results of the present study [ Table 2 ] showed a statistically highly significant increase in TSH levels in all cirrhosis patients compared to healthy controls ( P < 0.0001). El-Feki and Abdalla[ 17 ] concluded the same results. Antonelli et al .…”

Section: Discussionsupporting

confidence: 61%

A study of thyroid dysfunction in cirrhosis of liver and correlation with severity of liver disease

Punekar

Sharma

Jain

2018

Indian J Endocr Metab

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Introduction:Liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to triiodothyronine (T3) by Type 1 deiodinase.Materials and Methods:This case–control study included 100 decompensated liver cirrhosis patients (71 males and 29 females) and 100 apparently healthy controls (71 male and 29 female). Serum FT3, FT4, and thyroid-stimulating hormone (TSH) levels were measured using electrochemiluminescence immunoassay and analyses between cases versus healthy controls (Group 1) and further analyses in subgroups, cirrhosis with hepatic encephalopathy (HE) cases (n = 38) versus cirrhosis without HE cases (Subgroup 1), cirrhosis survivors (n = 84) versus cirrhosis nonsurvivors (Subgroup 2), HE survivors (n = 23) versus HE nonsurvivors (Subgroup 3). Results were also analyzed for severity of liver disease according to Child–Turcotte–Pugh (CTP) (Class A, B, and C), model for end-stage liver disease (MELD) score, and HE grades.Results:Most common etiology was alcohol (46%) and presentation was gross ascites (74%). Cirrhosis patients had statistically significant lower level of FT3 (P < 0.0001) and FT4 (P < 0.0001) but had higher level of TSH (P < 0.0001) compared with the controls. Cirrhosis with HE (n = 38) had significantly lower lever of FT3 (P < 0.0001) compared with cirrhosis without HE (n = 62), whereas there was no statistically significant difference in FT4 (P < 0.09) and TSH (P < 0.60) levels. FT3 level significantly low in HE Grade 4 patients compared with HE Grade 1 patients (P = 0.0001). In all cirrhotic patients, FT3 and FT4 were negatively correlated, but TSH level was positively correlated with total leukocyte counts, serum total bilirubin, aspartate transaminase, alanine transaminase, globulin, prothrombin time (PT), blood urea, serum creatinine, CTP, and MELD score. Overall, the most common abnormality seen was low T3 (low FT3) syndrome 41% (41 out of 100) in cases, 50% (19 out of 38) in cirrhosis with HE, and 32% (5 out of 16) in Non-survivors cases.Conclusion:The mean FT3 and FT4 levels were significantly decrease and mean TSH levels were significantly increase in liver cirrhosis patients compared to healthy controls. Level of FT3, FT4, and TSH also correlate with the severity of liver disease, level of FT3 can be used as prognostic marker for liver cirrhosis patients.

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Section: Discussionsupporting

confidence: 61%

A study of thyroid dysfunction in cirrhosis of liver and correlation with severity of liver disease

Punekar

Sharma

Jain

2018

Indian J Endocr Metab

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“…Recently an association between liver dysfunction and thyroid hormone has been elucidated in HCV patients [28–30]. Besides these we have not determined thyroid autoimmunity related parameters like serums Tg-Ab and TPO-Ab and ultrasound echogenicity in our patients.…”

Section: Discussionmentioning

confidence: 80%

“…Limitations of this study are its cross-sectional nature, comparatively low number of male patients, serum FT 3 determination in a few patients, and incomplete medical information like liver enzyme and biopsy status. Recently an association between liver dysfunction and thyroid hormone has been elucidated in HCV patients [ 28 – 30 ]. Besides these we have not determined thyroid autoimmunity related parameters like serums Tg-Ab and TPO-Ab and ultrasound echogenicity in our patients.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction in Non-Interferon Treated Hepatitis C Patients Residing in Hepatitis Endemic Area

Batool

Elahi

Saleem

et al. 2017

BioMed Research International

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Background Association of thyroid dysfunction (TD) with interferon treatment of HCV is well known to clinicians. However, a few studies have highlighted the role of hepatitis C virus per se in the development of TD. The aim of this study was to know the prevalence of TD in non-interferon treated HCV infected patients referred for thyroid function testing. Patients and Methods Among 557 ELISA-positive HCV patients 446 (341 females, 105 males) were selected for this study. Serums FT4, FT3, and TSH were determined by radioimmunoassay method. Results TD was detected in 15.2% of patients: 9.0% hypothyroidism and 6.3% hyperthyroidism. In increasing order subclinical hypothyroidism, overt hypothyroidism, overt hyperthyroidism, and subclinical hyperthyroidism were found in 4.7%, 4.3%, 3.6%, and 2.7% patients, respectively. Overall TD was more common in female than in male HCV patients but the difference was not significant (16.1% versus 12.4%; p = 0.648). Hyperthyroidism and subclinical hypothyroidism were slightly more common in female and overall hypothyroidism and overt hypothyroidism in male patients but the difference was not statistically significant (p > 0.05). The incidence of TD was relatively high in patients above 36 years (median age) but the difference was not statistically significant either collectively or in gender base groups (p > 0.05). Conclusion Prior to interferon treatment, HCV infection itself causes biochemical thyroid dysfunction in 15.2% of local HCV patients.

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“…A similar male predominance among such patients has been reported previously by Ali et al who observed it to be 1.5:1 in the local population [ 11 ]. El-Feki et al in 2016 reported a similar male to female ratio of 1.5:1 among Egyptian patients with CLD [ 19 ]. Mansour-Ghanaei et al in 2012 reported a male to female ratio of 1.9:1 among CLD patients in Iran [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

The Pattern of Dyslipidemia in Chronic Liver Disease Patients

Farooque¹,

Lohano²,

Dahri³

et al. 2021

Cureus

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A substantial proportion of patients with chronic liver disease had hyperlipidemia which varied with the severity of disease on Child-Pugh classification. Routine monitoring of the lipid profile of such patients is necessary for timely identification and management of dyslipidemia to improve the outcome of such patients. It also suggests an important role of lipid profile in the risk stratification and treatment of chronic liver disease patients and warrants further studies in this regard.

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Serum Level of Thyroid Hormones in Patients with Chronic Hepatitis C Virus Infection

Cited by 14 publications

References 15 publications

A study of thyroid dysfunction in cirrhosis of liver and correlation with severity of liver disease

A study of thyroid dysfunction in cirrhosis of liver and correlation with severity of liver disease

Thyroid Dysfunction in Non-Interferon Treated Hepatitis C Patients Residing in Hepatitis Endemic Area

The Pattern of Dyslipidemia in Chronic Liver Disease Patients

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