Serum level of transforming growth factor beta 1 is associated with left atrial voltage in patients with chronic atrial fibrillation

Abstract

BackgroundAtrial tissue fibrosis can cause electrical or structural remodeling in patients with atrial fibrillation. Transforming growth factor beta 1(TGF-β1) signaling acts as a central role in fibroblast activation. In this report, we aimed to investigate the relationship between serum level of TGF-β1 and mean left atrial voltage in patients with chronic atrial fibrillation (CAF).MethodsA total of 16 consecutive adult patients with CAF who underwent catheter ablation were enrolled. Blood samples for measurement of TGF-β1 were collected from periphery veins and coronary sinus before pulmonary vein isolation. The measurement was performed with a commercially available ELISA kit. Cardiac indices were measured using echocardiography. The left atrial electroanatomic mapping was performed after pulmonary vein isolation.ResultsSerum level of TGF-β1 in peripheral blood was higher than that in coronary sinus (p < 0.001). TGF-β1 serum level in coronary sinus negatively correlated with mean left atrial voltage (r = -0.650, p = 0.012), While periphery TGF-β1 level tended to be negatively correlated with mean left atrial voltage(r = -0.492, p = 0.053). Patients who treated with angiotensin II receptor antagonists had lower coronary sinus TGF-β1 serum level than those who did not treated with angiotensin II receptor antagonists (p = 0.046).ConclusionLevel of TGF-β1 in peripheral serum is higher than that in coronary sinus, and serum level of TGF-β1 in coronary sinus is negatively associated with mean left atrial voltage in patients with CAF, angiotensin II receptor antagonists could affect TGF-β1 serum level.

Atrial Myopathy Underlying Atrial Fibrillation

“…[ 156 – 161 ] For example, patients treated with angiotensin II receptor antagonists were found to have lower levels of TGF-beta1 than those not treated. [ 162 ] Clinically, the Routine Versus Aggressive Upstream Rhythm Control for Prevention of Early Atrial Fibrillation in Heart Failure (RACE III) trial randomised patients with persistent AF and mild–moderate heart failure to aldosterone antagonist, ACE inhibitors, statins, and cardiac rehab versus conventional therapy. At 1 year, sinus rhythm was present in 75% of the intervention group compared with 63% in the control group (OR 1.765; p=0.042).…”

The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates

“…High plasma levels of TGF-β1 have been correlated with increased LA volumes and reduced bipolar voltage on electroanatomic voltage mapping (260), but results regarding its effect on the incidence of AF have been contradictory (261)(262)(263).…”

Fibroid Heart Markers in Patients with Atrial Fibrillation

“…продемонстрирован более низкий уровень ТФР-β1 у пациентов с перманентной ФП, которые использовали антагонисты рецептора ангиотензина II, по сравнению с таковым у не принимавших подобные препараты. Это позволяет сделать вывод, что антагонисты рецептора ангиотензина II снижают миокардиальный фиброз, частично подавляя экспрессию ТФР-β1, однако небольшой размер выборки данного исследования ограничивает значимость полученных результатов, они требуют дальнейшего изучения [34].…”