Serum Level of Uromodulin as an Early Predictor Marker of Kidney Disorders

Abstract

BACKGROUND: Metabolic diseases are known to be risk factors of kidney injury. The glycoprotein Uromodulin Tamm-Horsfall protein is a biochemical marker specifically synthesized and secreted by kidney tubular epithelial cells.
 AIM: The study aimed to use novel biochemical parameters to predict early changes in renal functions and to use natural food supplements to help in the prevention and management of such conditions.
 METHODS: Crossover studies comparing two interventions trials. Subjects: Seventy obese females were included in this study. They were divided in two groups, first group (34 women) with mean age 45.82 ± 1.51 and mean body mass index (BMI) 35.65 ± 0.68 kg/m2, and second group (36 women) with mean age 49.80 ± 2.27, and mean BMI 37.67 ± 1.59. Intervention: All participants have followed a low caloric balanced regimen (1000–1200 Kcal/day) of the each groups consumed a different specific nutritional supplement composed mainly of whole grains and herbs. All patients were monitored clinically, anthropometrically, dietary 24 h recall and biochemically.
 RESULTS: After intervention all the recorded anthropometric parameters showed significant decreases at p ≤ 0.05–0.01. The serum uromodulin (sUMOD) increased significantly after intervention in both groups the increments were 15.56 and 9.37%. Numerically creatinine and urea decreased, while creatinine clearance increased.
 CONCLUSION: Data revealed the importance of using dietary therapy composed of hypocaloric diet with supplements made from whole grains and special herbs in management of obesity and its metabolic disorders. sUMOD proved to be an accurate biochemical marker that showed the kidneys’ response to the management in comparison to using usual diagnostic markers.

Metabolic syndrome and the risk of kidney diseases: the impact of life style modification

“…El-Shebini et al [42] used serum Uromodulin (sUMOD) as a novel biochemical marker to predict early changes in renal functions in obese participants and evaluate the effect of using dietary supplement made of special herbs and whole grains to help in the prevention and management of such conditions. The results showed that the measurement of the sUMOD proved to be an accurate and precise biochemical parameter to show the speed of the renal response to the management by comparison with using usual diagnostic old markers.…”