Serum level of zinc in asthmatic patients: A case–control study

Khanbabaee, Ghamartaj; Omidian, Ali; Imanzadeh, Farid; Adibeshgh, F.; Ashayeri-Panah, Mitra; Rezaei, Nima

doi:10.1016/j.aller.2012.07.008

Cited by 32 publications

(19 citation statements)

References 9 publications

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“…Zinc deficiency may exacerbate airway inflammation in asthma. 47 Some studies show an association between low zinc levels and asthma, [48][49][50][51][52] while others contradict these findings, [53][54][55][56] and systematic review evidence is lacking. One study found no relationship between allergic rhinitis and plasma zinc and another study found no relationship between allergic rhinitis and dietary zinc intake.…”

Section: Discussionmentioning

confidence: 99%

Zinc and atopic dermatitis: a systematic review and meta‐analysis

Gray

Dhana

Stein

et al. 2019

Acad Dermatol Venereol

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Zinc plays a central role in skin integrity via barrier and immune mechanisms and may also be relevant in the pathogenesis of atopic dermatitis (AD). However, little is known about the relationship between zinc and AD. We performed a systematic review to determine (i) the association between zinc levels or zinc deficiency and AD and (ii) the efficacy of oral zinc supplementation in the treatment of AD. We searched PubMed, Scopus, Web of Science and article references for observational studies on zinc levels or zinc deficiency in participants with AD vs. controls and for randomized control trials (RCTs) on zinc supplementation in AD. For observational studies, we calculated pooled standardized mean differences (SMDs) or odds ratios (ORs) along with 95% confidence intervals (CIs) using a random effects model. We included 14 observational studies and two RCTs. The pooled SMD demonstrated significantly lower serum (SMD 0.66, 95% CI 0.21–1.10, P = 0.004), hair (SMD 0.95, 95% CI 0.38–1.52, P = 0.001) and erythrocyte (SMD 0.95, 95% CI 0.38–1.52, P = 0.001) zinc levels in participants with AD compared to controls. Pooled unadjusted data from three studies showed a non‐significant increased odds of AD in those with zinc deficiency compared with those without zinc deficiency (OR = 1.50, 95% CI 0.71–3.16, P = 0.28). One RCT of oral zinc supplementation among AD patients with zinc deficiency showed improvement in extent and severity of AD, while another RCT among all AD patients showed no significant improvement. All the studies were of low or moderate quality. We conclude that low serum, hair and erythrocyte zinc levels are associated with AD. However, the poor quality of included studies makes interpretation of these results problematic. High‐quality observational studies are needed to confirm the association between low zinc levels and AD, and RCTs are required to evaluate the merit of zinc supplementation for the treatment or prevention of AD.

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Section: Discussionmentioning

confidence: 99%

Zinc and atopic dermatitis: a systematic review and meta‐analysis

Gray

Dhana

Stein

et al. 2019

Acad Dermatol Venereol

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“…24 Later study by Khanbabaee and colleagues also found that the mean serum zinc level in pediatric asthma patients was 70.5 mg/dL, and that 42% of patients were hypozincemic. 17 They found that there was a significant association between zinc level and severity of disease. Both studies were conducted to evaluate zinc status, using a cross-sectional study design, during non-exacerbation periods.…”

Section: Discussionmentioning

confidence: 99%

Zinc Supplementation in Children with Asthma Exacerbation

Rerksuppaphol

2016

Pediatric Reports

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Zinc deficiency has demonstrated an association with the risk of asthma. This study aimed to evaluate the efficacy of zinc supplementation in reducing the severity of childhood asthma exacerbation. A number of 42 children with asthma exacerbation admitted to the hospital were randomized to receive either zinc bis-glycinate (30 mg elemental zinc/day) or a placebo in adjuvant to the standard treatment. The pediatric respiratory assessment measure (PRAM) was used to measure the asthma severity. The primary outcome was a change in asthma severity from the baseline to the end of study. The study found that PRAM score in the zinc group showed a more rapid decrease compared to the control group at the 24-hour (2.2±1.3 vs. 1.2±1.3; P = 0.015) and 48-hour (3.4±2.0 vs. 2.2±1.8; P = 0.042) intervals. At admission, overall mean serum zinc level was 63.8 mg/dL and 57.1% of children had zinc deficiency with no difference in prevalence between groups. PRAM scores did not differ between children with low and normal zinc status. In conclusion, zinc supplementation as the adjuvant therapy to the standard treatment during asthma exacerbation resulted in rapid lessening of severity.

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“…15,16 On the contrary, the antiinflammatory, anti-apoptotic effects of zinc on respiratory epithelium rather than smooth muscles of the respiratory tract make it a better prophylactic agent than a bronchodilator drug. 3,4 However, our idea behind screening bronchodilator effect of zinc in acute attack of asthma was based on the inhibitory effect of magnesium on NMDA receptors. Relaxation of the smooth muscles by inhibition of calcium channels by magnesium is basically an indirect effect mediated through inhibition of NMDA receptors.…”

Section: Discussionmentioning

confidence: 99%

“…This is because apart from the evidences of its deficiency in bronchial asthma patients, zinc has shown cellular and molecular level antiasthma effects. [3][4][5] Daily supplementation of low dose of zinc was proven to be beneficial at least in terms of reduction in severity of clinical signs and symptoms of bronchial asthma in children. 6 Unlike zinc, the deficiency of magnesium in asthma patients was not found in a clinical study but has shown the weak but significant effects in treatment of acute asthma.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of zinc as anti-asthma agent: a preclinical study on guinea pigs

Hiremath

Priya

2017

Int J Basic Clin Pharmacol

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Background: The role of intravenous magnesium sulfate in acute asthma is restricted to severe and resistant cases while that of zinc as prophylactic agent. What is quite interesting is to know the benefits of zinc in acute attack of asthma and that of magnesium as prophylactic agent. The objective of the study was to analyze the bronchodilatory effects of zinc sulfate and prophylactic role of magnesium sulfate using a preclinical model of histamine and acetylcholine induced acute bronchial asthma in conscious guinea pigs.Methods: Animals were exposed to histamine diphosphate (1%) and acetylcholine chloride (10%) aerosols before and after administration of the respective test drugs after acute and sub-acute treatment regimens. Time for onset of preconvulsive dyspnea (PCD) was noted and compared within and between the treatment groups interms of percentage of protection.Results: Magnesium significantly prolonged time for convulsion compared to control group. But this difference was insignificant when compared with antihistaminic and anticholinergic drugs. Zinc was superior to control and magnesium treatment group in sub-acute treatment study.Conclusions: Magensium sulfate has bronchodilatory effects but no prophylactic effects while it is vice versa with zinc sulfate.

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Serum level of zinc in asthmatic patients: A case–control study

Abstract: As for high rate of hypozincemia in the asthmatic children, evaluation of serum zinc level in asthmatic children could be suggested, while zinc substitution in the diet of those with hypozincemia could be recommended.

Cited by 32 publications

References 9 publications

Zinc and atopic dermatitis: a systematic review and meta‐analysis

Zinc and atopic dermatitis: a systematic review and meta‐analysis

Zinc Supplementation in Children with Asthma Exacerbation

Evaluation of zinc as anti-asthma agent: a preclinical study on guinea pigs

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