Serum levels of apelin, salusin-alpha and salusin-beta in normal pregnancy and preeclampsia

Şimşek, Yavuz; Çelik, Önder; Yılmaz, Ercan; Karaer, Abdullah; Dogan, Cagdas; Aydın, Süleyman; Özer, Ali

doi:10.3109/14767058.2012.660221

Cited by 18 publications

(15 citation statements)

References 25 publications

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“…Apelin Cord blood levels negatively correlates with birth weight [125] " in obesity [126] and T2D obese [127]; " in maternal GDM; negatively correlates with birth weight [125]; " [128] or # [129] in PE…”

Section: Adipocytokinesmentioning

confidence: 99%

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Management of reproduction and pregnancy complications in maternal obesity: Which role for dietary polyphenols?

et al. 2013

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Obesity is a global and dramatic public health problem; maternal obesity represents one of the main risk factors of infertility and pregnancy complications as it is associated with adverse maternal and offspring outcomes. In the last few years, adipose tissue dysfunction associated with altered adipocytokine secretion has been suggested to play a critical role in all the phases of reproductive process. Obesity is a nutrition-related disorder. In this regard, dietary intervention strategies, such as high intake of fruit and vegetables, have shown significant effects in both preserving health and counteracting obesity-associated diseases. Evidence has been provided that polyphenols, important constituents of plant-derived food, can influence developmental program of oocyte and embryo, as well as pregnancy progression by modulating several cellular pathways. This review will examine the controversial results so far obtained on adipocytokine involvement in fertility impairment and pregnancy complications. Furthermore, the different effects exerted by polyphenols on oocyte, embryo, and pregnancy development will be also taken in account.

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Section: Adipocytokinesmentioning

confidence: 99%

“…Apelin is also expressed in placenta and, is most likely required for normal vascular development since it shows properties consistent with a role in angiogenesis . Abnormal serum expression of apelin, either increased or reduced levels compared to controls, appears to be associated with PE .…”

Section: Adipocytokines In Reproduction and Pregnancymentioning

confidence: 99%

Management of reproduction and pregnancy complications in maternal obesity: Which role for dietary polyphenols?

et al. 2013

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“…10 Few studies investigating the role of apelin in preeclampsia showed controversial results. [11][12][13][14][15][16][17][18][19] Accurate assessment of specific fragment concentrations is substantial in order to establish the biological role of apelin in preeclampsia. However, previous studies evaluated total apelin concentrations as serum apelin levels without discriminating the individually active specific forms.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum apelin‐13 and apelin‐36 concentrations in preeclamptic pregnancies

Gürlek

Yılmaz

Durakoğlugil

et al. 2019

J of Obstet and Gynaecol

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Aim Recent studies suggest that apelin can be a novel potential therapeutic mediator to improve the diagnosis, and treatment of preeclampsia. This study aimed to investigate the association of serum apelin‐13 and apelin‐36 with preeclampsia and to detect their relationship with preeclampsia‐associated perinatal morbidity. Methods Forty‐four women with preeclampsia were included as the study group. Forty‐four healthy pregnant women, at similar gestational week with similar gravidity, formed the control group. The clinical findings, biochemical indicators, maternal and perinatal outcomes, and the serum concentrations of apelin‐36 and apelin‐13 were evaluated. The levels of apelin‐13 and apelin‐36 were determined with commercial kits using a competition‐based enzyme‐linked immunosorbent assay method. Results The mean gestational age at sampling was 35.77 ± 2.515 weeks in the preeclamptic group, 36.45 ± 2.057 weeks in the control group (P = 0.270). Maternal serum apelin‐36 and apelin‐13 concentrations were significantly lower in patients with preeclampsia compared to the individuals in the control group (P = 0.030 and P = 0.005, respectively). The optimal cut‐off points of apelin‐36 and apelin‐13 measurements for discriminating between preeclampsia and controls were evaluated by the receiver–operator curve analysis. The results showed that apelin‐13 and apelin‐36 are moderately successful markers to differentiate subjects with preeclampsia from healthy pregnant women. The concentrations of apelin‐13 and apelin‐36 in both groups were not statistically different in cases with and without adverse fetal/neonatal outcomes. Conclusion In conclusion, we investigated serum apelin‐13 and apelin‐36 concentrations in preeclamptic patients and demonstrated markedly lower maternal concentrations compared to healthy pregnant women.

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“…The reports on circulating apelin in preeclampsia are not entirely consistent either, although the majority report an increase. Bortoff et al (2012) observed a decrease in circulating apelin in preeclamptic women relative to normal pregnancy, while three groups reported increases in circulating apelin during early and late onset, as well as mild and severe, preeclampsia (Simsek et al, 2012;Inuzuka et al, 2013;Kucur et al, 2014). The higher circulating levels may serve a compensatory role to counteract systemic vasoconstriction in preeclampsia.…”

Section: Apelin Receptormentioning

confidence: 99%

G-Protein-coupled receptors as potential drug candidates in preeclampsia: targeting the relaxin/insulin-like family peptide receptor 1 for treatment and prevention

Conrad

2016

Hum. Reprod. Update

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There is a strong scientific rationale for RXFP1 activation in severe preeclampsia by administration of relaxin, relaxin analogs or small molecule mimetics, in order to mollify the disease pathogenesis for safe prolongation of pregnancy, thus allowing time for more complete fetal maturation, which is a primary therapeutic endpoint in treating the disease. In light of recent data implicating deficient or defective decidualization as a potential etiological factor in preeclampsia and the capacity of relaxin to promote endometrial maturation, the prophylactic application of relaxin to reduce the risk of preeclampsia is a plausible therapeutic approach to consider. Finally, given its pleiotropic and beneficial attributes particularly in the cardiovascular system, relaxin, although traditionally considered as a 'pregnancy' hormone, is likely to prove salutary for several disease indications in the non-pregnant population.

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Serum levels of apelin, salusin-alpha and salusin-beta in normal pregnancy and preeclampsia

Cited by 18 publications

References 25 publications

Management of reproduction and pregnancy complications in maternal obesity: Which role for dietary polyphenols?

Management of reproduction and pregnancy complications in maternal obesity: Which role for dietary polyphenols?

Evaluation of serum apelin‐13 and apelin‐36 concentrations in preeclamptic pregnancies

G-Protein-coupled receptors as potential drug candidates in preeclampsia: targeting the relaxin/insulin-like family peptide receptor 1 for treatment and prevention

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