Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Nitric Oxide Metabolite Levels in Preeclampsia Patients

Noorbakhsh, Marjan; Kianpour, Maryam; Nematbakhsh, Mehdi

doi:10.1155/2013/104213

Cited by 20 publications

(12 citation statements)

References 51 publications

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“…Upon tea (black tea and green tea) incubation, the expression of asymmetric dimethyl arginine was decreased considerably in preeclamptic placental trophoblast. Marjan et al, (30) has reported that asymmetric dimethyl arginine is an anti-angiogenic factor that reduces vascular endothelial growth factor expression in endothelial cells and prevents the formation of nitric oxide from nitric oxide synthase, which fits our data. Asymmetric dimethyl arginine affects the growth factors at their production and activity level.…”

Section: Discussionsupporting

confidence: 92%

Antioxidant Efficacy of Black Tea and Green Tea Equally Modulates Vasculogenic Factors in Preeclamptic Placental Trophoblast: A Comparative Study

Perumal¹,

Susai²

2018

IJCRR

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Aim: Preeclampsia is hypertensive disorder of human pregnancy. Trophoblast, a prime cell of the placenta, is affected during preeclampsia due to the imbalance between oxidant and antioxidants resulting in aberrant cellular vascularization. Vasculogenesis is regulated by the endothelial nitric oxide synthase (eNOS), a potent vasodilator, regulating the expression of growth factors. Vascular endothelial growth factor (VEGF) is a prime regulator of vasculogenesis. Placental growth factor (PLGF) plays a crucial role in placental development during pregnancy. Synthetic drugs can hardly be used under complicated pregnancy. The requirement for herbal remedies renders essential regulatory mechanism to ensure adequate protection from preeclampsia. Methodology: In the current study, black tea and green tea were used to assess the stress markers (LPO and TAC) and vasculogenic factors (ADMA, eNOS, VEGF-C, and PLGF) in normotensive and preeclamptic placental trophoblast. Results: The increased expression of LPO, ADMA and decreased TAC, eNOS, VEGF-C, PLGF were observed in preeclamptic placental trophoblast. On tea incubation, vasculogenic proteins were significantly altered in preeclamptic placental trophoblast when compared with their respective subjects. Discussion: Our present study results reveal that protective effect of black tea is equal to the green tea. This may be due to the tea polyphenols produces a beneficiary effect in the case of the preeclamptic placenta. Conclusion: The present study concludes that tea with or without fermentation process has a significant impact on crucial vasculogenic factors. This effect can be suitably exploited to avoid further complications in preeclamptic pregnancy. .

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Section: Discussionsupporting

confidence: 92%

Antioxidant Efficacy of Black Tea and Green Tea Equally Modulates Vasculogenic Factors in Preeclamptic Placental Trophoblast: A Comparative Study

Perumal¹,

Susai²

2018

IJCRR

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“…272 Clinical studies have shown increased 273 or decreased 274–277 plasma nitrite levels in preeclamptic compared with normal pregnant women. Also, urinary nitrite levels may not differ in preeclamptic versus normal pregnant women.…”

Section: Mmps and Vascular Dysfunction In Hypertensive Pregnancy Amentioning

confidence: 99%

Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia

Chen

Khalil

2017

Progress in Molecular Biology and Translational Science

235

168

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Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing fetus. These pregnancy-associated changes involve significant uteroplacental and vascular remodeling. Matrix metalloproteinases (MMPs) are important regulators of vascular and uterine remodeling. Increases in MMP-2 and MMP-9 have been implicated in vasodilation, placentation and uterine expansion during normal pregnancy. The increases in MMPs could be induced by the increased production of estrogen and progesterone during pregnancy. MMP expression/activity may be altered during complications of pregnancy. Decreased vascular MMP-2 and MMP-9 may lead to decreased vasodilation, increased vasoconstriction, hypertensive pregnancy and preeclampsia. Abnormal expression of uteroplacental integrins, cytokines and MMPs may lead to decreased maternal tolerance, apoptosis of invasive trophoblast cells, inadequate remodeling of spiral arteries, and reduced uterine perfusion pressure (RUPP). RUPP may cause imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic vascular endothelial growth factor and placental growth factor, or stimulate the release of inflammatory cytokines, hypoxia-inducible factor, reactive oxygen species, and angiotensin AT1 receptor agonistic autoantibodies. These circulating factors could target MMPs in the extracellular matrix as well as endothelial and vascular smooth muscle cells, causing generalized vascular dysfunction, increased vasoconstriction and hypertension in pregnancy. MMP activity can also be altered by endogenous tissue inhibitors of metalloproteinases (TIMPs) and changes in the MMP/TIMP ratio. In addition to their vascular effects, decreases in expression/activity of MMP-2 and MMP-9 in the uterus could impede uterine growth and expansion and lead to premature labor. Understanding the role of MMPs in uteroplacental and vascular remodeling and function could help design new approaches for prediction and management of preeclampsia and premature labor.

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“…Clinical studies have shown conflicting results, reporting increased (Noorbakhsh et al, 2013) or decreased (Schiessl et al, 2006; Ehsanipoor et al, 2013; Eleuterio et al, 2013; Pimentel et al, 2013) serum and plasma nitrite levels in PE compared with Norm-Preg women. Other studies have shown a decrease in serum levels of nitrites in PE during the first trimester that normalizes in the third trimester (Matsubara et al, 2010).…”

Section: Decreased Endothelium-derived Relaxing Factors In Preeclamentioning

confidence: 99%

Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia

Possomato-Vieira

Khalil

2016

Advances in Pharmacology

191

117

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Preeclampsia is a pregnancy-related disorder characterized by hypertension, and could lead to maternal and fetal morbidity and mortality. Although the causative factors and pathophysiological mechanisms are unclear, endothelial dysfunction is a major hallmark of preeclampsia. Clinical tests and experimental research have suggested that generalized endotheliosis in the systemic, renal, cerebral and hepatic circulation could decrease endothelium-derived vasodilators such as nitric oxide, prostacyclin and hyperpolarization factor and increase vasoconstrictors such as endothelin-1 and thromboxane A2, leading to increased vasoconstriction, hypertension and other manifestation of preeclampsia. In search for the upstream mechanisms that could cause endothelial dysfunction, certain genetic, demographic and environmental risk factors have been suggested to cause abnormal expression of uteroplacental integrins, cytokines and matrix metalloproteinases, leading to decreased maternal tolerance, apoptosis of invasive trophoblast cells, inadequate spiral arteries remodeling, reduced uterine perfusion pressure (RUPP), and placental ischemia/hypoxia. RUPP may cause imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic factors vascular endothelial growth factor and placental growth factor, or stimulate the release of other circulating bioactive factors such as inflammatory cytokines, hypoxia-inducible factor-1, reactive oxygen species, and angiotensin AT1 receptor agonistic autoantibodies. These circulating factors could then target endothelial cells and cause generalized endothelial dysfunction. Therapeutic options are currently limited, but understanding the factors involved in endothelial dysfunction could help design new approaches for prediction and management of preeclampsia.

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Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Nitric Oxide Metabolite Levels in Preeclampsia Patients

Cited by 20 publications

References 51 publications

Antioxidant Efficacy of Black Tea and Green Tea Equally Modulates Vasculogenic Factors in Preeclamptic Placental Trophoblast: A Comparative Study

Antioxidant Efficacy of Black Tea and Green Tea Equally Modulates Vasculogenic Factors in Preeclamptic Placental Trophoblast: A Comparative Study

Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia

Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia

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