Serum levels of cancer biomarkers in diabetic and non-diabetic proteinuric patients: a preliminary study

Turgutalp, Kenan; Özhan, Onur; Helvacı, İlter; Ata, Alper; Arıcan, Ali; Boztepe, Burcu; Kıykım, Ahmet

doi:10.1515/cclm-2012-0657

Cited by 14 publications

(19 citation statements)

References 17 publications

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“…Gul et al found significant correlation between CA19-9 and HbA1c in diabetic patients [10]. There is only one study investigating CEA levels in diabetes mellitus, which found lower CEA levels in diabetics than controls, which contradicts our results [12]. The researchers also found higher CA19-9 levels, and they did not correlate these markers with HbA1c.…”

Section: Discussioncontrasting

confidence: 93%

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The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels

et al. 2014

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BackgroundDiabetes mellitus is closely related to pancreas cancer. In this study we aimed to investigate the effect of hyperglycemia on tumor and inflammation markers, as well as pancreatic exocrine functions.MethodsA total of 98 consecutive diabetic patients with poor glycemic control, and 50 healthy controls were included in the study. We measured hsCRP, erythrocyte sedimentation rate (ESR), CA19-9, CEA, amylase and lipase in addition to routine biochemistry tests, before and after euglycemia was achieved.ResultsFasting blood glucose, HbA1c, CA19-9, CEA, hsCRP, ESR, triglycerides, AST, ALT, GGT, ALP, total cholesterol and LDL-C levels decreased significantly with the regulation of glycemic control. Amylase and lipase levels increased with the regulation of glycemic control. After glycemic control, CA19-9 and CEA levels were still higher, whereas amylase and lipase levels were still lower in the diabetic group compared with the control group. Basal HbA1c showed significant correlation with CA19-9, CEA, amylase and lipase.ConclusionsWe propose to repeat observations of tumor markers after hyperglycemia is resolved, in order to avoid unnecessary invasive tests. Our data also suggest that pancreatic exocrine function was improved with lowering blood glucose in a short period of time.

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Section: Discussioncontrasting

confidence: 93%

“…There is a relation between endocrine and exocrine pancreas reserve [11]. To our knowledge, there is only one study investigating CEA levels in diabetes mellitus, which found lower CEA levels in diabetics than controls [12]. In the above-mentioned studies, tumor markers were not studied after euglycemia was achieved.…”

Section: Introductionmentioning

confidence: 99%

The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels

et al. 2014

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“…In addition, the mechanism through which DM and prostate cancer are related has not been fully elucidated. Men with DM are known to generally have lower prostate-specific antigen (PSA) level but larger prostate size than others not having DM (Hammarsten and Hogstedt, 2001;Berger et al, 2005;Werny et al, 2006;Fowke et al, 2007;Turgutalp et al, 2013). Also, it can be suggested that the reported protective effect of DM may be due to the differences in PCa screening among diabetic and non-diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus and HbA1c Levels Associated with High Grade Prostate Cancer

Özbek

Ötünçtemur²,

Dursun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Pirpose: The aim of this study to analyze the association between history of diabetes mellitus (DM) with risk of prostate cancer (PCa) and cancer grade among men undergoing radical prostatectomy for PCa. Materials and Methods: 50 patients with DM and 50 patients without DM who undervent radical prostatectomy (RP) were included in the study. Age at biopsy, height, weight, digital rectal examination (DRE), pre-biopsy PSA levels, prostate volume, histopathologic diagnosis after surgery and gleason scores were collected data from all patients. Histologic material obtained at biopsy was given a Gleason score; tumours with a Gleason score ≥7 were considered high grade and <7 were considered low grade. Results: The mean age at the time of biopsy was 63.7 in patients with DM and 61.6 in patients without DM. Diabetic men had significantly lower PSA levels (p=0.01). Mean PSA level 7.04±2.85 in patients with DM and 8.7±2.86 in patients without DM, respectively. Also, diabetic men had higher RP tumor grade than men without DM (p=0.04). We found that HbA1c levels were higher in patients who have high grade prostate cancer (p<0.05). Conclusions: Diabetic men undergoing RP have lower PSA levels and have significantly higher grade PCa. We must be careful for screening PCa in patients with DM. Although the patients had lower PSA levels, they might have high grade disease.

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“…Serum and plasma have become the most widely used sample for diabetic biomarker studies212223. Depletion of serum prior to proteomic analysis by immunoaffinity subtraction of specific proteins through the use of targeted polyclonal antibody columns and spin filters has recently emerged as a promising tool for serum prefractionation19.…”

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confidence: 99%

2D-DIGE as a strategy to identify serum biomarkers in Mexican patients with Type-2 diabetes with different body mass index

Gómez-Cardona

Hernández-Domínguez

Velarde‐Salcedo

et al. 2017

Sci Rep

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Obesity and type 2 diabetes(T2D) are the most prevalent and serious metabolic diseases affecting people worldwide. However racial and ethnic disparities seems to be a risk factor for their development. Mexico has been named as one of the largest populations with the highest prevalence of diabetes and obesity. The aim of this study was to identify novel T2D-associated proteins in Mexican patients. Blood samples were collected from 62 Mexican patients with T2D and they were grouped according to their body mass index(BMI). A panel of 10 diabetes and obesity serum markers was determined using MAGPIX. A comparative proteomics study was performed using two-dimensional difference in-gel electrophoresis(2D-DIGE) followed by mass spectrometry(LC-MS/MS). We detected 113 spots differentially accumulated, in which 64 unique proteins were identified, proteins that were involved in metabolism pathways, molecular transport, and cellular signalling. Four proteins(14-3-3, ApoH, ZAG, and OTO3) showing diabetes-related variation and also changes in relation to obesity were selected for further validation by western blotting. Our results reveal new diabetes related proteins present in the Mexican population. These could provide additional insight into the understanding of diabetes development in Mexican population and may also be useful candidate biomarkers.

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Serum levels of cancer biomarkers in diabetic and non-diabetic proteinuric patients: a preliminary study

Abstract: CBs levels seem to be changed in different proteinuric patients. This condition should be kept in mind when evaluating CBs levels in proteinuric patients.

Cited by 14 publications

References 17 publications

The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels

The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels

Diabetes Mellitus and HbA1c Levels Associated with High Grade Prostate Cancer

2D-DIGE as a strategy to identify serum biomarkers in Mexican patients with Type-2 diabetes with different body mass index

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