Serum Levels of Chloramphenicol in Children,Rhesus Monkeys, and Cats after Administration ofChloramphenicol Palmitate Suspension

Effect of Additives on the Transformation Behavior of l-Phenylalanine in Aqueous Solution

“…This was due to the growth of crystals of the stable form with the concurrent dissolution of crystals of a less stable form . The dissolution and bioavailability due to different polymorphs has been well-documented. , Therefore, it is necessary to control conditions to obtain the desired polymorph and, more importantly, to prevent the transformation of the desired form to another polymorph.…”

Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil

“…In the solid state, there is a transition from α form (Form B) to β form (Form A), being that this process is irreversible. These crystalline forms differ in their physical-chemical properties (Banerjee et al, 1971;Miyamoto et al, 1973). Aguiar et al (1967) demonstrated that the absorption of the α form (Form B) of chloramphenicol palmitate was significantly higher than the absorption of the α form (Form B) in humans.…”

“…Aguiar and Zelmer (1969), continuing their work, related the thermal behavior of chloramphenicol palmitate with the absorption data in vivo and concluded, through thermodynamic parameters, that when the free energy difference between polymorphs is high, alterations of absorption profiles can occur, however, if the free energy difference is low, there are no significant differences in absorption. Banerjee et al (1971) studied the absorption in vivo of the polymorph A and the amorphous form of suspensions of chloramphenicol palmitate and concluded that the absorption of the amorphous form is "significantly superior". During the development of pharmaceutical formulations, the main objective is to formulate physically and chemically stable products as long as they present bioavailiblability.…”

Pharmaceutical Sciences—1971: Literature Review of Pharmaceutics

“…An investigation in children of the absorption of amorphous and polymorph A forms of chloramphenicol palmitate suspensions made with polysorbate 80 showed that both forms were absorbed (1338). Although the absorption of the amorphous form was definitely superior, the polymorph A form in suspension with a surfactant was also absorbed to a considerable extent in children, maintaining blood levels of chloramphenicol for a prolonged period.…”