2016
DOI: 10.1016/j.jdiacomp.2016.07.017
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Serum levels of copeptin are associated with type 2 diabetes and diabetic complications in Chinese population

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Cited by 25 publications
(18 citation statements)
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“…Besides the stage of UACR as risk factors for predicting DR and DME, there were several other risk factors recognised in the logistic regression analyses: DM duration and LDL for DR, and LDL for DME. DM duration had been found as the risk factor in prediction of DR in many previous studies 21 22. As for LDL, there were several studies23–26 found associations between high level of LDL with DR/DME, which had similar results with our study.…”
Section: Discussionsupporting
confidence: 91%
“…Besides the stage of UACR as risk factors for predicting DR and DME, there were several other risk factors recognised in the logistic regression analyses: DM duration and LDL for DR, and LDL for DME. DM duration had been found as the risk factor in prediction of DR in many previous studies 21 22. As for LDL, there were several studies23–26 found associations between high level of LDL with DR/DME, which had similar results with our study.…”
Section: Discussionsupporting
confidence: 91%
“…15 Furthermore, copeptin is higher among patients with T2DM than in those without. 6,16 Taken together with the present findings, it seems reasonable to conclude that activation of the vasopressin system relates to T2DM. Moreover, that a possible pathway is via the IGF-1 axis via increased secretion of IGFBP-1.…”
Section: Discussionsupporting
confidence: 84%
“…Cross-sectional and prospective studies in the general population have shown associations between plasma copeptin and albuminuria or renal function decline (Meijer et al, 2010;Enhorning et al, 2013;Roussel et al, 2015). High circulating copeptin concentration was also associated with the development and progression of diabetic nephropathy in patients with type 2 diabetes (Boertien et al, 2013;Velho et al, 2013;Hu et al, 2015;Pikkemaat et al, 2015;Zhu et al, 2016), and with prevalence of ESRD in subjects with long-standing type 1 diabetes (Bjornstad et al, 2016;Velho et al, 2016). Experimental data suggests a causal role of vasopressin in renal dysfunction through activation of the V2-receptor (V2R).…”
Section: Introductionmentioning
confidence: 99%