Serum Levels of Cytokines in Subjects With Generalized Chronic and Aggressive Periodontitis Before and After Non‐Surgical Periodontal Therapy: A Pilot Study

Duarte, Poliana Mendes; Rocha, Marcelo da Silva; Sampaio, Eduardo González de; Mestnik, Maria Josefa; Feres, Magda; Figueiredo, Luciene Cristina; Bastos, Marta Ferreira; Faveri, Marcelo

doi:10.1902/jop.2010.090732

Cited by 107 publications

(117 citation statements)

References 44 publications

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“…The earlier investigation involved a greater number of participants with a greater variation in the level of periodontitis, whereas in this study The circulating levels of IL-17A (range 2 pg/ml -360 pg/ml), IL-17E (4 pg/ml -96 pg/ml), TNF (range = 0 pg/ml -42 pg/ml) and IL-6 (range = 0 pg/ml -34 pg/ml) reported in this study are similar to levels reported in other studies [7,8,13,14]. In addition the trends in these mediators post-therapy are generally in agreement with other studies [7,8,13,14]. While there is no exact agreement on the timing of reassessments between studies, some comparisons can be made.…”

Section: Discussionsupporting

confidence: 91%

“…While there is no exact agreement on the timing of reassessments between studies, some comparisons can be made. Indeed, at the 6 week post-treatment reassessment (R1) findings for TNF and IL-6 were similar to results reported in other studies [7,[13][14][15][16][17]. However, unlike some other studies, an increase in the levels of IL-6 and TNF, was observed after R1 with higher levels being recorded at R2; although these generally remained below baseline values.…”

Section: Discussionsupporting

confidence: 88%

“…The effect of periodontal therapy on levels of IL-17 family cytokines in biological fluids is less well known. Previous studies have suggested that GCF levels of IL-17A in patients with chronic periodontitis [11] and serum levels of IL-17A in patients with aggressive periodontitis [7] are reduced after non-surgical therapies. To date, however, no studies have investigated the effect of therapies on serum levels of IL-17E or the serum IL-17A:IL-17E ratio.…”

Section: Introductionmentioning

confidence: 97%

“…Furthermore, elevated levels of IL-17A have been detected in serum [6][7][8] saliva [8,9] and gingival crevicular fluid (GCF) [8,10,11] of periodontitis patients. Serum and GCF levels of IL-17A have also been demonstrated to correlate with clinical attachment loss in patients with chronic periodontitis [7,8,11] and aggressive periodontitis [7].…”

Section: Introductionmentioning

confidence: 99%

“…In particular the effects of therapies on serum interleukin-6 (IL-6) and Tumor necrosis factor (TNF) are well documented [7,[13][14][15][16][17]. The effect of periodontal therapy on levels of IL-17 family cytokines in biological fluids is less well known.…”

Section: Introductionmentioning

confidence: 99%

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The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

et al. 2016

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. (2016) The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A: IL-17E ratio. Clinical Oral Investigations, 20(9), pp. 2529-2537. (doi:10.1007/s00784-016-1749 This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/116253/ The serum IL-17A:IL-17E ratio has previously been demonstrated to be a clinical marker of periodontitis. The aim of this study was to determine the effects of non-surgical periodontal treatment on the serum IL-17A:IL-17E ratio. MATERIALS AND METHODS:Forty chronic periodontitis patients completed this study and received periodontal treatment comprising scaling and root planing plus ultrasonic debridement. Clinical data were recorded at baseline, six weeks (R1) after treatment completion (full-mouth or quadrant-scaling and root planing) and 25 weeks after baseline (R2). Serum samples were taken at each time point and cytokines concentrations determined by ELISA. RESULTS:Following treatment, statistically significant reductions were noted in clinical parameters. However, IL-17A and IL-17E concentrations were significantly greater than baseline values before-and after-adjusting for smoking. The IL-17A:IL-17E ratio was lower at R1 and R2. Serum IL-6 and TNF levels were significantly lower at R1 only. Also exclusively at R1, serum IL-17A and IL-17E correlated positively with clinical parameters, while the IL-17A:IL-

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

et al. 2016

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Systemic Manifestations of Periodontal Disease

Stepaniuk

Hinrichs

2012

Veterinary Periodontology

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The down‐regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis

Mijailović

Nikolic

Djinic

et al. 2019

Journal of Periodontology

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Background:The exact mechanisms of bone resorption in periodontitis have not been fully elucidated. The aims of this study were to analyze the expression of Notch signaling molecules, bone remodeling mediators, and pro-inflammatory cytokines in periodontitis patients and to determine their potential correlations. Methods:The study included 130 individuals: 40 with aggressive periodontitis (AP group), 40 with chronic periodontitis (CP group), and 50 periodontally healthy controls. Total RNA was extracted from gingival crevicular fluid samples and relative gene expression of investigated molecules (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF-, IL-17, RANKL, and OPG) was determined by reverse transcriptase -realtime polymerase chain reaction (RT-qPCR). Results:In AP group, a significant increase of Notch 2, TNF-, IL-17 and RANKL and a significant decrease of Notch 1 and Jagged 1 expression were observed compared to control group (P = 0.023, P = 0.005, P = 0.030, and P = 0.001 P = 0.031 and P = 0.029, respectively). Notch 2 and RANKL were also overexpressed in CP group compared to controls (P = 0.001 and P = 0.011). Significant correlations were observed in AP group between expression levels of the analyzed genes. Conclusion:The present findings implicate Notch 2 overexpression in the ethiopathogenesis of bone resorption in aggressive and chronic periodontitis. The downregulation of Notch 1 and Jagged 1 and loss of their osteoprotective function might cause a more excessive osteoclast formation and contribute to greater osteolysis in aggressive periodontitis. K E Y W O R D Saggressive periodontitis, bone remodeling, gene expression, periodontitis 554

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Serum Levels of Cytokines in Subjects With Generalized Chronic and Aggressive Periodontitis Before and After Non‐Surgical Periodontal Therapy: A Pilot Study

Cited by 107 publications

References 44 publications

The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

Systemic Manifestations of Periodontal Disease

The down‐regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis

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