Serum levels of decabromodiphenyl ether (BDE-209) in women from different European countries and possible relationships with lifestyle and diet

Berg, Martin van den; Houba, Remko; Leslie, H.A.; Cantón, Rocío F.; Thomsen, Cathrine; Álvarez-Pedrerol, Mar; Deu, Jordi Sunyer; Tongeren, Martie van; Brunekreef, Bert; Boer, Jacob de

doi:10.1016/j.envint.2017.06.014

Cited by 15 publications

(1 citation statement)

References 98 publications

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“…Our vision is that an in vitro/HBM approach can use the HBM4EU project -in parallel to the NHANES project in the UStogether with more comprehensive human relevant in vitro data to make 'alternative' risk assessment much more valuable to finally be able to 'stand-alone'. US [22] Denmark [36] US [22] Denmark [55] France [56,57] Belgium [58] US [59,60] UK [61][62][63] Greece [64] Spain [63,[65][66][67][68] Netherlands [63] Germany [69] Denmark [70,71] Sweden [72][73][74] Norway [63] Canada [75] Australia [76] Greece [64] Netherlands [77] Belgium [49,78] Germany [69] Sweden [79,80] Norway [81] In vitro data (endpoints ranked according to potency. The study used for RCR calculation in bold)…”

Section: Discussionmentioning

confidence: 99%

Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

Johansson

Boberg

Dybdahl

et al. 2019

Current Opinion in Toxicology

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Today detailed risk assessment can only be performed for a few percent of the total number of current-use chemicals due to lack of data. Toxicity data is therefore needed for a substantial number of untested chemicals, a task that requires improved and faster chemical risk assessment strategies that are cost-efficient, human relevant and ethically responsible. In this commentary we use a case study on five known thyroid toxic chemicals (perfluorooctanesulfonic acid (PFOS), triclosan, tetrabromobisphenol A (TBBPA), decabromodiphenyl ether (BDE-209), and hexabromocyclododecane (HBCD)) to explore the use of in vitro data for hazard assessment together with human biomonitoring (HBM) data for exposure assessment when evaluating human risk. Based on the case study we conclude that in vitro and HBM data can be used for risk ranking of chemicals. We envision that an in vitro/HBM approach can use data from studies such as the big European initiative HBM4EU together with human relevant in vitro data to make alternative risk assessment more valuable to finally be able to 'stand-alone'.

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Section: Discussionmentioning

confidence: 99%

Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

Johansson

Boberg

Dybdahl

et al. 2019

Current Opinion in Toxicology

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Study on association between human plasma polybrominated diphenyl ethers (PBDEs) and thyroid homeostasis and carcinoma

Wang,

Chen

et al. 2024

Environ Geochem Health

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Metabolism toxicity and susceptibility of decabromodiphenyl ether (BDE-209) exposure on BRL cells with insulin resistance

Mao

Tang

Liao

et al. 2022

Environ Sci Pollut Res

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Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance (IR) and has attracted worldwide attention due to its high prevalence. As a typical persistent organic pollutant, decabromodiphenyl ether (BDE-209) has been detected in food and human samples and the concentration trends to increase year by year. In addition, it has been proved to have the potential to increase the risk of IR, but it is rarely reported whether it could aggravate IR in T2DM. Therefore, in this study, the IR-BRL (Buffalo Rat Liver cells with IR) model was applied to study the metabolism toxicity and susceptibility of BDE-209. Results showed that BDE-209 could inhibit the glucose absorption and increase the levels of TC and TG, ultimately lead to the disorder of glucolipid metabolism in IR-BRL cells.Besides, it also could cause cell damage by increasing the levels of AST, ALT and MDA in cells. Moreover, its potential mechanisms were to: (1) affect the transport of glucose, synthesis of glycogen and fatty acid via IRS-1/GLUT4 and IRS-1/PI3K/AKT/GSK-3β pathways; (2) impact the proliferation and differentiation by regulating the expression of Mek1/2, Erk1/2 and mTOR proteins and genes. Furthermore, susceptibility analysis showed that there was a signi cant synergism interaction between IR and BDE-209, which suggested that IR-BRL cells were more susceptible to the metabolism toxicity induced by BDE-209.

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Serum levels of decabromodiphenyl ether (BDE-209) in women from different European countries and possible relationships with lifestyle and diet

Cited by 15 publications

References 98 publications

Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

Study on association between human plasma polybrominated diphenyl ethers (PBDEs) and thyroid homeostasis and carcinoma

Metabolism toxicity and susceptibility of decabromodiphenyl ether (BDE-209) exposure on BRL cells with insulin resistance

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