Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise

Iso, Tatsuya; Sunaga, Hiroaki; Matsui, Hiroki; Kasama, Shu; Oshima, Naomi; Haruyama, Hikari; Furukawa, Nozomi; Nakajima, Kiyomi; Machida, Tetsuo; Murakami, Masami; Yokoyama, Tetsuji; Kurabayashi, Masahiko

doi:10.1016/j.clinbiochem.2017.05.021

Cited by 21 publications

(43 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, androgen may partially contribute to the gender difference in serum FABP4 levels 72) . Circulating FABP4 levels are significantly correlated with norepinephrine levels during exercise testing 73) , being consistent with FABP4 secretion from adipocytes via β -adrenergic-mediated lipolytic mechanisms 54–56) . Loss of body weight by exercise training 74) and bariatric surgery 75, 76) induces a significant reduction in FABP4 concentrations.…”

Section: Circulating Fabp4 Levelmentioning

confidence: 67%

Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases

Furuhashi

2019

J Atheroscler Thromb

209

177

View full text Add to dashboard Cite

The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Review Fatty acid-binding proteins (FABPs), a family of lipid chaperones, contribute to systemic metabolic regulation via several lipid signaling pathways. Fatty acid-binding protein 4 (FABP4), known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays important roles in the development of insulin resistance and atherosclerosis in relation to metabolically driven low-grade and chronic inflammation, referred to as 'metaflammation'. FABP4 is secreted from adipocytes in a non-classical pathway associated with lipolysis and acts as an adipokine for the development of insulin resistance and atherosclerosis. Circulating FABP4 levels are associated with several aspects of metabolic syndrome and cardiovascular disease. Ectopic expression and function of FABP4 in cells and tissues are also related to the pathogenesis of several diseases. Pharmacological modification of FABP4 function by specific inhibitors, neutralizing antibodies or antagonists of unidentified receptors would be novel therapeutic strategies for several diseases, including obesity, diabetes mellitus, atherosclerosis and cardiovascular disease. Significant roles of FABP4 as a lipid chaperone in physiological and pathophysiological conditions and the possibility of FABP4 being a therapeutic target for metabolic and cardiovascular diseases are discussed in this review. Fatty Acid-Binding Proteins (FABPs) Fatty acid trafficking in cells affects many aspects of cellular function 3). Fatty acids act both as an energy source and as signals for metabolic regulations including gene expression, inflammatory and metabolic responses, and growth and survival pathways. Fatty acid-binding proteins (FABPs), a family of intracellular lipid chaperones, regulate lipid trafficking and responses in cells and are linked to metabolic and inflammatory pathways 3-6). FABPs are abundantly expressed 14-15-kDa proteins that reversibly bind hydrophobic ligands, such as long-chain fatty acids and other lipids. It has been proposed that FABPs actively facilitate the transport of fatty acids to specific organelles in the cell for lipid oxidation in the mitochondrion or peroxisome, transcriptional regulation in the nucleus, signaling, trafficking and membrane synthesis in the endoplasmic reticulum (ER), and regula-Copyright©2019 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

show abstract

Section: Circulating Fabp4 Levelmentioning

confidence: 67%

Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases

Furuhashi

2019

J Atheroscler Thromb

209

177

View full text Add to dashboard Cite

show abstract

“…Perilipin1 is associated with lipid metabolism and adipocyte lipolysis during adipocyte differentiation for lipid storage droplet formation in adipocytes [ 31 ]. Fatty acid-binding protein 4 is mainly released from adipocytes and is strongly correlated with obesity metabolic diseases as a clinical marker of metabolic and vascular morbidity and mortality [ 32 ]. GLUT4 facilitates the transport of glucose that is expressed primarily in adipose tissues, which controls glucose uptake [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Antiadipogenic Effects of Loganic Acid in 3T3-L1 Preadipocytes and Ovariectomized Mice

et al. 2018

View full text Add to dashboard Cite

Obesity is caused by an excess storage of body fat, resulting from a chronic imbalance between energy intake and expenditure. Gentiana lutea L. (GL) root has been reported to reduce lipid accumulation in the aortic wall of diabetic rats. Here, we performed fractionation and isolation of the bioactive constituent(s) that may be responsible for the antiadipogenic effects of the GL root extract. A single compound, loganic acid, was identified as a candidate component in the 30% ethanol extract of GL. Loganic acid treatment significantly decreased the adipocyte differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. The expression of key adipogenesis-related genes such as adiponectin (Adipoq), peroxisome proliferator-activated receptor gamma (Pparg), lipoprotein lipase (Lpl), perilipin1 (Plin1), fatty acid binding protein 4 (Fabp4), glucose transporter type 4 (Slc2a4), CCAAT/enhancer-binding protein alpha (Cebpa), and tumor necrosis factor-alpha (Tnf) were significantly reduced following treatment with loganic acid. In vivo experiments in an ovariectomy-induced obesity mouse model showed that loganic acid (oral administration with 10 and 50 mg/kg/day) significantly inhibited body weight gain, total fat increase, fatty hepatocyte deposition in the liver, and adipocyte enlargement in the abdominal visceral fat tissues. These results suggest that loganic acid in the GL root extract has antiadipogenic effects in vitro and in vivo. Loganic acid may be beneficial for the prevention and treatment of obesity, particularly in menopausal obese women.

show abstract

“…A previous study revealed that the decreased activity of PPARγ led to insulin resistance and metabolic dysregulation ( 11 ). It has also been shown that high-intensity exercise significantly increases serum concentrations of FABP4 secreted by adipocytes via β-adrenergic mediated lipolysis ( 47 ). Moreover, adiponectin supplementation in pregnant mice prevents maternal obesity-associated fetal overgrowth by improving insulin resistance and restoring normal mTORC1 signaling ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Role of exercise and rapamycin on the expression of energy metabolism genes in liver tissues of rats fed a high‑fat diet

Dai

et al. 2020

Mol Med Rep

View full text Add to dashboard Cite

The mTor pathway serves an important role in the development of insulin resistance induced by obesity. exercise improves obesity-associated insulin resistance and hepatic energy metabolism; however, the precise mechanism of this process remains unknown. Therefore, the present study investigated the role of rapamycin, an inhibitor of mTor, on exercise-induced expression of hepatic energy metabolism genes in rats fed a high-fat diet (HFd). a total of 30 male rats were divided into the following groups: normal group (n=6) fed chow diets and HFd group (n=24) fed an HFd for 6 weeks. The HFd rats performed exercise adaptation for 1 week and were randomly divided into the four following groups (each containing six rats): i) Group of HFd rats with sedentary (H group); ii) group of HFd rats with exercise (He group); iii) group of HFd rats with rapamycin (Hr group); and iv) group of HFd rats with exercise and rapamycin (Her group). Both He and Her rats were placed on incremental treadmill training for 4 weeks (from week 8-11). Both Hr and Her rats were injected with rapamycin intraperitoneally at the dose of 2 mg/kg once a day for 2 weeks (from week 10-11). all rats were sacrificed following a 12-16 h fasting period at the end of week 11. The levels of mitochondrial and oxidative enzyme activities, as well as of the expression of genes involved in energy metabolism were assessed in liver tissues. Biochemical assays and oil red staining were used to assess the content of hepatic triglycerides (TGs). The results indicated that exercise, but not rapamycin, reduced TG content in the liver of HFd rats. Further analysis indicated that rapamycin reduced the activity of cytochrome c oxidase, but not the activities of succinate dehydrogenase and β-hydroxyacyl-coa dehydrogenase in the liver of HFD rats. Exercise significantly upregulated the mrna expression of peroxisome proliferator-activated receptor γ coactivator 1 β, while rapamycin exhibited no effect on the mrna expression levels of hepatic transcription factors associated with energy metabolism enzymes in the liver of HFd rats. collectively, the results indicated that exercise reduced TG content and upregulated mitochondrial metabolic gene expression in the liver of HFd rats. Moreover, this mechanism may not involve the mTor pathway.

show abstract

Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise

Cited by 21 publications

References 20 publications

Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases

Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases

Antiadipogenic Effects of Loganic Acid in 3T3-L1 Preadipocytes and Ovariectomized Mice

Role of exercise and rapamycin on the expression of energy metabolism genes in liver tissues of rats fed a high‑fat diet

Contact Info

Product

Resources

About