Serum levels of functional T-regs in vitiligo: our experience and mini-review of the literature

Richetta, Antonio Giovanni; D'Epiro, S; Salvi, Monica; Campoli, Marco; Giancristoforo, Simona; Mattozzi, Carlo; Macaluso, Laura; Luci, Cecilia; Cantisani, Carmen; Carboni, Valentina; Zanniello, Ramona; Zampetti, M; Milana, Bernardina; Morrone, Stefania; Calvieri, Stefano

doi:10.1684/ejd.2013.1986

Cited by 11 publications

(13 citation statements)

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“…In our study, the percentage of CD4 + CD25 + T cells in the peripheral blood of vitiligo patients was significantly lower than healthy controls. This matches the results of several previous reports [ 17 – 19 ].…”

Section: Discussionsupporting

confidence: 93%

“…In vitiligo, the dysfunction of Tregs could result from the alteration of generation, peripheral survival, activation, suppressor mechanisms, or migratory behavior of these cells [ 27 , 28 ]. Decreased percentage of peripheral CD4 + CD25 + Tregs and decreased expression of FoxP3 + might impair the suppressive activity of Treg cells on cell proliferation with breakage of tolerance to melanocyte self-antigens which could contribute to the pathogenesis of vitiligo [ 17 ]. A previous study had indicated that an imbalance of CD8 + cytotoxic T lymphocytes and natural Tregs in frequency and function might be involved in the progression of generalized vitiligo.…”

Section: Discussionmentioning

confidence: 99%

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Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity

Hegab

Attia

2015

Dermatology Research and Practice

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Background. Vitiligo is an acquired depigmentary skin disorder resulting from autoimmune destruction of melanocytes. Regulatory T cells (Tregs), specifically CD4+CD25+ and Forkhead box P3+ (FoxP3+) Tregs, acquired notable attention because of their role in a variety of autoimmune pathologies. Dysregulation of Tregs may be one of the factors that can break tolerance to melanocyte self-antigens and contribute to vitiligo pathogenesis. Methods. In order to sustain the role of Tregs in pathogenesis and disease activity of vitiligo, surface markers for CD4+CD25+ and FoxP3+ peripheral Tregs were evaluated by flow cytometry in 80 Egyptian patients with nonsegmental vitiligo in addition to 60 healthy control subjects and correlated with clinical findings. Results. Vitiligo patients had significantly decreased numbers of both peripheral CD4+CD25+ and FoxP3+ T cells compared to control subjects (11.49% ± 8.58% of CD4+ T cells versus 21.20% ± 3.08%, and 1.09% ± 0.96% versus 1.44% ± 0.24%, resp., P < 0.05 for both). Peripheral numbers of CD4+CD25+ and FoxP3+ Tregs correlated negatively with VIDA score. Conclusion. Treg depletion with impaired immune downregulatory function might play a key role in the autoimmune conditions beyond nonsegmental vitiligo particularly in active cases. Effective Treg cell-based immunotherapies might be a future hope for patients with progressive vitiligo.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity

Hegab

Attia

2015

Dermatology Research and Practice

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“…Using IPA software, altogether 993 associations between the gene groups and diseases were found. Among the first 20 diseases, the terms ‘dermatological’, ‘immunological’ and ‘inflammation’ are found, which are all related to vitiligo [ 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…We also performed an analysis showing the top functions of the genes with an altered expression pattern in vitiligo patients' PBMCs (table 4 ). The genes are participating in processes such as cell death, survival and signaling, inflammation, and oxidative stress among others, which are all associated with vitiligo pathogenesis [ 27 , 28 , 29 ]. Furthermore, with this analysis, a group of 23 genes associated with dermatological diseases and conditions, immunological disease and inflammatory disease was found (fig.…”

Section: Resultsmentioning

confidence: 99%

“…The present study showed that genes with an altered mRNA expression level in vitiligo patients are also associated with other diseases. The functional analysis revealed the gene groups to be linked to dermatological conditions, immunological and inflammatory diseases as well as cell survival, which all fit the vitiligo profile [ 27 , 28 ]. However, the genes which gave the highest statistical significance in the analysis are also associated with lichen planus.…”

Section: Discussionmentioning

confidence: 99%

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Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients

et al. 2014

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Vitiligo is an idiopathic disorder characterized by depigmented patches on the skin due to a loss of melanocytes. The cause of melanocyte destruction is not fully understood. The aim of this study was to detect the potential pathways involved in the vitiligo pathogenesis to further understand the causes and entity of vitiligo. For that the transcriptome of peripheral blood mononuclear cells of 4 vitiligo patients and 4 control subjects was analyzed using the SOLiD System platform and whole transcriptome RNA sequencing application. Altogether 2,470 genes were expressed differently and GRID2IP showed the highest deviation in patients compared to controls. Using functional analysis, altogether 993 associations between the gene groups and diseases were found. The analysis revealed associations between vitiligo and diseases such as lichen planus, limb-girdle muscular dystrophy type 2B, and facioscapulohumeral muscular dystrophy. Additionally, the gene groups with an altered expression pattern are participating in processes such as cell death, survival and signaling, inflammation, and oxidative stress. In conclusion, vitiligo is rather a systemic than a local skin disease; the findings from an enormous amount of RNA sequencing data support the previous findings about vitiligo and should be further analyzed. © 2014 S. Karger AG, Basel

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Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics

Dwivedi

Kemp

Laddha

et al. 2015

Autoimmunity Reviews

111

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Vitiligo is a hypomelanotic autoimmune skin disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes.Regulatory T cells (Tregs) are crucial to the development of self-tolerance and so are major foci in the study of autoimmune pathogenesis of vitiligo. This review will summarise recent findings concerning the role of Tregs in the pathogenesis of vitiligo. In addition, as antigen-specific Tregs are a potential route for the reinstatement of immune tolerance, new strategies that expand or induce de novo generation of Tregs and which are currently being investigated as therapies for other autoimmune diseases, will be discussed. These approaches will highlight the opportunities for Treg cell-based therapeutics in vitiligo.4

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Serum levels of functional T-regs in vitiligo: our experience and mini-review of the literature

Cited by 11 publications

References 0 publications

Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity

Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity

Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients

Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics

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