Serum Levels of Ghrelin, Tumor Necrosis Factor-  and Interleukin-6 in Infants and Children with Congenital Heart Disease

Afify, Mohamed F.; Mohamed, Gamal B.; El-Maboud, Mohamed Abd; Abdel-Latif, Esmat A

doi:10.1093/tropej/fmp036

Cited by 25 publications

(28 citation statements)

References 23 publications

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“…IL-6 can also be upregulated and released from renal tubular epithelial cells in response to injury and plays a fundamental role in the pathophysiology of AKI [32]. Additionally, IL-6 production is increased by the myocardium in states of congestive heart failure, cardiac ischemia, and congenital heart disease [33-35]. Preoperatively, we found that IL-6 was statistically different in patients who did and did not go on to develop stage 2/3 AKI.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery

et al. 2015

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Background Children undergoing cardiac surgery may exhibit a pronounced inflammatory response to cardiopulmonary bypass (CPB). Inflammation is recognized as an important pathophysiologic process leading to acute kidney injury (AKI). The aim of this study was to evaluate the association of two inflammatory cytokines interleukin (IL)-6 and IL-10 with AKI and other adverse outcomes in children after CPB surgery. Methods This is a sub-study of the Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI) cohort, including 106 children from 1 month to 18 years old undergoing CPB. Plasma IL-6 and IL-10 were measured preoperatively and postoperatively on days 1 (within 6 hours after surgery) and 3. Results Stage 2/3 AKI, defined by atleast a doubling of baseline serum creatinine or dialysis, was diagnosed in 24 (23%) patients. Preoperative IL-6 was significantly higher in patients with stage 2/3 AKI vs. without stage 2/3 AKI (median (IQR), 2.6 (0.6-4.9) vs. 0.6 (0.6-2.2), p=0.03). After adjustment for clinical and demographic variables, the highest preoperative IL-6 tertile was associated with a six-fold increased risk for stage 2/3 AKI compared with the lowest tertile (adjusted OR 6.41 (CI: 1.16-35.35)). IL-6 and IL-10 increased significantly after surgery, peaking postoperatively on day 1. First postoperative IL-6 and IL-10 did not significantly differ between patients with vs. without stage 2/3 AKI. Elevated IL-6 on day 3 was associated with longer hospital stay (p=0.0001). Conclusions Preoperative plasma IL-6 is associated with development of stage 2/3 AKI and may be prognostic of resource utilization.

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Section: Discussionmentioning

confidence: 99%

Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery

et al. 2015

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“…Açlık hormonu olarak bilinen ghrelin, malnütrisyon ve büyüme geriliğindeki enerji metabolizmasındaki eksikliği dengelemek üzere artar. Doğuştan kalp hastalığı olan çocuklarda serum ghrelin düzeylerinin yüksek olduğu ve ghrelin düzeyleri ile VKİ arasında negatif ilişki olduğu gösterilmiştir (31,32). Sık geçirilen enfeksiyonlar DKH'lı çocuklardaki büyüme geriliği ve malnütrisyon gelişiminin en önemli nedenlerinden birisidir (6,28).…”

Section: Discussionunclassified

“…(33) yaptıkları çalışmalarında malnütrisyonun konjestif kalp yetmezliği ve siyanozu olan hastalarda belirgin olduğunu bildirmektedir. Doğuştan kalp hastalığı olan çocuklarda TNF-alfa ve IL-6 seviyelerinin yüksek olduğu gösterilmiştir (31). Serum ghrelin düzeylerinin asiyanotik DKH olanlarda siyanotik DKH olanlardan daha yüksek olması ve serum ghrelin düzeyleri ile TNF-alfa düzeyleri arasındaki pozitif ilişkinin saptanması; malnütrisyonun konjestif kalp yetmezliği ve kronik hipoksi ile ilişkili olduğunu desteklemektedir (31).…”

Section: Discussionunclassified

“…Doğuştan kalp hastalığı olan çocuklarda TNF-alfa ve IL-6 seviyelerinin yüksek olduğu gösterilmiştir (31). Serum ghrelin düzeylerinin asiyanotik DKH olanlarda siyanotik DKH olanlardan daha yüksek olması ve serum ghrelin düzeyleri ile TNF-alfa düzeyleri arasındaki pozitif ilişkinin saptanması; malnütrisyonun konjestif kalp yetmezliği ve kronik hipoksi ile ilişkili olduğunu desteklemektedir (31). Ülkemizde yapılan bir çalışmada ağırlığı <5 persantil olanların; en fazla siyanotik lezyonu olan ve/veya kalp yetmezliği tedavisi alan hastalar olduklarını bildirilmişlerdir (17).…”

Section: Discussionunclassified

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The association between pulmonary arterial hypertension and malnutrition in children who had acyanotic congenital heart diseases with left to right shunt: an observational study

Altın¹,

Karataş²,

Şap³

et al. 2012

Anadolu Kardiyol Derg

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Sol-sağ şantlı doğuştan kalp hastalığı olan çocuklarda pulmoner arteriyel hipertansiyonla malnütrisyonun ilişkisi: Gözlemsel bir çalışmaThe association between pulmonary arterial hypertension and malnutrition in children with congenital heart diseases with left-to-right shunt: an observational study Özgün Araşt›rma Original Investigation ABSTRACTObjective: To evaluate the association between the degree of pulmonary arterial hypertension (PAH) and the level of malnutrition in children with acyanotic congenital heart diseases and left-to-right shunt, and especially to evaluate the development rates of malnutrition in patients with borderline PAH. Methods:The study was performed with data of 327 patients with acyanotic congenital heart diseases and left-to-right shunt and underwent cardiac catheterization between January 2001-February 2011. The design of the study was retrospective and observational. All patients were evaluated with anthropometric measurements, echocardiography and cardiac catheterization. They were classified according to the mean pulmonary artery pressure and level of malnutrition. Chi-square, ANOVA and Kruskal-Wallis tests were used for statistical analysis. Normally and abnormally distributed data were analyzed with Pearson and Spearman correlation tests respectively. Results: Malnutrition was detected in 94.8% of patients with PAH and 17.2% of no PAH patients according to Gomez classification (p<0.001). In addition, malnutrition was detected in 23.5% (16/68) of borderline PAH group. A negative association was detected between mean pulmonary arterial pressure and body weight for age (Gomez) and z scores of weight (p<0.001 for all). Z scores of weight and height were significantly decreased in patients with PAH in contrast to no PAH group (p<0.001, p<0.01 respectively). There was no statistical difference between no PAH and borderline PAH groups according to Gomez classification and relative body weight formula, however z scores of weight in borderline PAH group were decreased compared with no PAH group (p<0.001). . Sınırda PAH'ı olanların ise %23.5'inde (16/68) malnütrisyon tespit edildi. Ortalama pulmoner arter basıncı ile yaşa göre vücut ağırlığı (Gomez) ve kilo z skorları arasında negatif ilişki mevcuttu (her ikisi için p<0.001). Kilo ve boy z skorları da PAH olanlarda olmayanlara göre belirgin düşüktü (sırasıyla p<0.001, p<0.01). Gomez sınıflaması ve rölatif vücut ağırlığına göre PAH olmayan ve sınırda PAH olan gruplar arasında fark yoktu, ancak sınırda PAH grubunun kilo z skorları PAH olmayan gruba göre düşüktü (p<0.001). Sonuç: Asiyanotik sol-sağ şantlı DKH'lı çocuklarda PAB arttıkça, beraberinde malnütrisyon derecesinin de ağırlaştığı görüldü. Sınırda PAH'ı olan hastaların olmayanlara göre malnütrisyona daha fazla eğilimli olduğu izlendi, ancak bu konuda daha geniş kapsamlı araştırmaların yapılması gerektiği düşünüldü. (Anadolu Kardiyol Derg 2012; 12: 150-9) Anahtar kelimeler: Çocuk, malnütrisyon, doğuştan kalp hastalığı, pulmoner arteriyel hipertansiyon

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“…Recently, researchers found that total plasma ghrelin levels were elevated in adult patients with idiopathic pulmonary arterial hypertension, and increased plasma ghrelin levels correlated positively with pulmonary artery systolic pressure (PASP) and nitric oxide (NO) [40]. Although total plasma ghrelin levels were higher in children with CHD [1,18,42], none of the study subjects had PH. In addition, the acylated ghrelin which possesses biological activity has not been investigated in children with PH-CHD.…”

Section: Introductionmentioning

confidence: 99%

Plasma Levels of Acylated Ghrelin in Children with Pulmonary Hypertension Associated with Congenital Heart Disease

Xia

Jia

et al. 2015

Pediatr Cardiol

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This study aims to estimate plasma levels of acylated ghrelin in children with pulmonary hypertension (PH) associated with congenital heart disease (CHD) and to correlate the levels of acylated ghrelin with endothelin-1 (ET-1), nitric oxide (NO), and clinical hemodynamic parameters. We investigated the plasma concentration of acylated ghrelin, ET-1, NO, and the hemodynamic parameters in 20 children with CHD, 20 children with PH-CHD, and 20 normal children. Plasma-acylated ghrelin and NO levels were significantly higher in CHD group than in control subjects (P < 0.001). Moreover, plasma-acylated ghrelin, ET-1, and NO levels were significantly elevated in PH-CHD group compared with the CHD group (P < 0.05). In PH-CHD children, plasma-acylated ghrelin levels correlated positively with pulmonary artery systolic pressure (PASP; r = 0.740, P < 0.001), pulmonary artery diastolic pressure (PADP; r = 0.613, P = 0.004), right ventricular systolic pressure (RVSP; r = 0.642, P = 0.002), mean pulmonary arterial hypertension (mPAP; r = 0.685, P = 0.001), right ventricle diameter (RVD; r = 0.473, P = 0.035), pulmonary artery trunk diameter (PAD; r = 0.613, P = 0.004), NO (r = 0.463, P = 0.04), and ET-1 (r = 0.524, P = 0.018). Plasma-acylated ghrelin levels were elevated both in CHD and in PH-CHD. Increased acylated ghrelin levels correlated positively with ET-1, NO, PASP, PADP, RVSP, mPAP, RVD, and PAD. Acylated ghrelin may be a new biomarker of PH-CHD.

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Serum Levels of Ghrelin, Tumor Necrosis Factor- and Interleukin-6 in Infants and Children with Congenital Heart Disease

Cited by 25 publications

References 23 publications

Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery

Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery

The association between pulmonary arterial hypertension and malnutrition in children who had acyanotic congenital heart diseases with left to right shunt: an observational study

Plasma Levels of Acylated Ghrelin in Children with Pulmonary Hypertension Associated with Congenital Heart Disease

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