Serum levels of high sensitivity C reactive protein and malondialdehyde in chronic kidney disease

B.H, Rakshitha Gowda; K.S, Meera; Mahesh, E

doi:10.5958/2319-5886.2015.00116.2

Cited by 2 publications

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“…These results were unsymmetrical with (ShiP P et al, 2012) who found that the mean of hs-CRP was decreased in HD patients. This study showed that the inflammatory marker in HD patients is the presence of proinflammatory state as evidenced by significant increase in hsCRP concentration caused by a synergism of different mechanisms, such as malnutrition, oxidative stress, genetic factors and chronic inflammation (Panichi et al, 2001); in addition, underlying etiology of CKD, such as diabetes or hypertension is by itself a major contributory factor to the existing inflammation (Amanullah et al, 2010;Gowda et al, 2015). Alterations in the immune system in CKD by uremia are associated with a state of immune dysfunction characterized by immune-depression that contributes to the high prevalence of infections among HD patients (LagrandP P et al, 1999).…”

Section: Human High Sensitivity C-reactive Protein (Hs-crp) Level In Four Study Groupsmentioning

confidence: 98%

Correlation of Chemerin with some Immunological Parameters in Type II Diabetes Mellitus Patients on Hemodialysis in Ramadi General Hospital

2021

JJBS

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Diseases of kidney are among the most important causes of death in many countries. The major causes of chronic kidney disease include diabetes mellitus and chronic hypertension. This study was designed to evaluate some hematological and inflammation aspects in 95 patients, divided into (35) hemodialysis patients with diabetes, (35) hemodialysis patients without diabetes and (25) diabetes patients, and who attended at Ramadi General Hospital, in addition to (25) samples as control subject. Chemerin, Interleukin-18 (IL-18) and high sensitive C-reactive protein (hs-CRP) were established by ELISA. The results showed serum chemerin, interleukin-18 and hs-CRP were significantly higher in HD patients with diabetes (230.13±78.26 ng/ml at P=0.034, 677.23±99.14 pg/mL at P=0.026, and 15.77±2mg/L at P=0.048), respectively compared with control (110±20.42ng/ml, 143.68±35.78pg/mL, and 4.64±1.27mg/L), respectively. The results showed the significant and positive correlations between chemerin and hs-CRP or chemerin and IL-18 (r=0.149 at P=0.004 or r=0.123 at P=0.0325 in control), (r=0.165 at P=0.007 or r =0.190 at P=0.024 in diabetic patients), (r=0. 237 at P=0.0036 or r =0.263 at P= 0.038 in HD patients with diabetic) and (r=0. 0.235 at P = 0.0081or r=0.248 at P = 0.041in HD patients without diabetic) respectively. The mean of hemoglobin (Hb), Packed Cells Volume (PCV), Red Blood cells (RBC), White Blood Cells (WBC) and Lymphocytes were significantly decreased in HD patients without diabetes (8.55±0.63g/L (at p=0.0423), 27.63±1.31%(at p=0.028), 3.12±0.56 ˟10P 12 P \ L (at p=0.035), 6.7±0.53 ˟10P 9 P /L (at p=0.021) and 30.23±5.84%(at p= 0.046), respectively compared with control. The mean of Monocytes% (17.23±7.28% at p=0.031) and Granulocyte% (59.31±9.45 % at p=0.042) were significantly higher in HD patients with diabetes, while mean of Mononocytes% was significant lower in diabetic patients. This study suggests a significant role of chemerin, hs-CRP and IL-18 in the pathogenesis and progression of diabetic complications, and we can use these parameters for predicting the progression of diabetic nephropathy in the early stages of CKD.

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Section: Human High Sensitivity C-reactive Protein (Hs-crp) Level In Four Study Groupsmentioning

confidence: 98%

Correlation of Chemerin with some Immunological Parameters in Type II Diabetes Mellitus Patients on Hemodialysis in Ramadi General Hospital

2021

JJBS

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Section: Human High Sensitivity C-reactive Protein (Hs-crp) Level In Four Study Groupsmentioning

confidence: 98%

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2021

JJBS

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Instructions to AuthorsScopes Study areas include cell biology, genomics, microbiology, immunology, molecular biology, biochemistry, embryology, immunogenetics, cell and tissue culture, molecular ecology, genetic engineering and biological engineering, bioremediation and biodegradation, bioinformatics, biotechnology regulations, gene therapy, organismal biology, microbial and environmental biotechnology, marine sciences. The JJBS welcomes the submission of manuscript that meets the general criteria of significance and academic excellence. All articles published in JJBS are peerreviewed. Papers will be published approximately one to two months after acceptance.

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Serum levels of high sensitivity C reactive protein and malondialdehyde in chronic kidney disease

Cited by 2 publications

References 0 publications

Correlation of Chemerin with some Immunological Parameters in Type II Diabetes Mellitus Patients on Hemodialysis in Ramadi General Hospital

Correlation of Chemerin with some Immunological Parameters in Type II Diabetes Mellitus Patients on Hemodialysis in Ramadi General Hospital

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