Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity

Abstract

Ìåòà. Âèâ÷èòè âì³ñò àäãåç³éíèõ ìîëåêóë òà Å-ñåëåêòèíó â ñèðîâàòö³ êðîâ³ õâîðèõ ç àðòåð³éíîþ ã³ïåðòåí糺þ â ïîºäíàíí³ ç öóêðîâèì ä³àáåòîì òà îaeèð³ííÿì. Ìàòåð³àë òà ìåòîäè. Îáñòåaeåíî 41 õâîðèé ç àðòåð³éíîþ ã³ïåðòåí糺þ òà öóêðîâèì ä³àáåòîì, 18 -àðòåð³éíîþ ã³ïåðòåí糺þ òà îaeèð³ííÿì, 10 -ç àðòåð³éíîþ ã³ïåð-òåí糺þ òà íîðìàëüíîþ ìàñîþ ò³ëà, 18 -êîíòðîëü. Âì³ñò ICAM-I, VCAM òà Å-ñåëåêòèíó âèçíà÷àëè ³ìóíîôåðìåíòíèì ìåòîäîì. Ðåçóëüòàòè ïðåäñòàâëåí³ ÿê ñåðåä-íº±ñòàíäàðòíå â³äõèëåííÿ. ³ðîã³äí³ñòü â³äì³ííîñò³ ñå-ðåäí³õ âåëè÷èí âèçíà÷àëè çà êðèòåð³ºì U-êðèòåð³ºì Ìàííà-Ó³òí³. Êîðåëÿö³éíèé àíàë³ç ïðîâîäèëè ç âèêîðèñòàííÿì êîåô³ö³ºíòà ϳðñîíà. Äëÿ âñòàíîâëåííÿ âïëèâó ÷èííèê³â âèêîðèñòîâóâàâñÿ áàãàòîôàêòîðíèé ðåãðåñ³éíèé àíàë³ç. Ðåçóëüòàòè é îáãîâîðåííÿ. Âèÿâëåíî ï³äâèùåííÿ ICAM-I ó ïàö³ºíò³â ç àðòåð³éíîþ ã³ïåðòåí糺þ ÿê â ïîºäíàíí³ ç öóêðîâèì ä³àáåòîì, îaeèð³ííÿì, òàê ³ ç íîðìàëüíîþ ìàñîþ ò³ëà, â ïîð³âíÿíí³ ç êîíòðîëüíîþ ãðóïîþ (Abstract SERUM LEVELS OF ICAM-I, VCAM, AND Å-SELECTIN IN ARTERIAL HYPERTENSION WITH TYPE 2 DIABETES AND OBESITY вÂÅÍÜ ICAM-I, VCAM, Å-ÑÅËÅÊÒÈÍÓ ÏÐÈ ÀÐÒÅвÉÍ²É Ã²ÏÅÐÒÅÍDz¯, ÙÎ ÑÓÏÐÎÂÎÄAEÓªÒÜÑß ÖÓÊÐÎÂÈÌ Ä²ÀÁÅÒÎÌ, ÎAEÈвÍÍßÌ Ìîãèëüíèöüêà Ë.À. Õìåëüíèöüêà îáëàñíà ë³êàðíÿ (ãîëîâíèé ë³êàð -Ôëàêñåìáåðã À.Ñ.) Åíäîêðèíîëî´³÷íå â³ää³ëåííÿ (çàâ. -Ë.². Ìóêîìåëà)Aim of this study was to determinate serum levels of ICAM-I, VCAM, and Å-selectin in patients whit arterial hypertension with or without type 2 diabetes mellitus and obesity. Material and Methods. We examined 41 hypertensive patients with type 2 diabetes, 18 obese hypertensive patients without diabetes, 10 normal weight hypertensive patients without diabetes, and 18 healthy control subjects. Serum levels of ICAM-I, VCAM, and Å-selectin were determined by immunoenzyme assay. The data were presented as means±SD. Statistical analysis was performed using the Mann-Whitney U-test, Pearson rank correlation coefficient, and multiple regression analysis. Results and Discussion. We found an increased serum level of ICAM-I in the hypertensive patients with type 2 diabetes, with and without obesity compared to the controls (Conclusion. The revealed changes may reflect an endothelial dysfunction mostly pronounced in patients with arterial hypertension, type 2 diabetes mellitus, and obesity. Hyperglycemia, dyslipidemia, insulin resistance, and obesity appear to be significant contributing factors leading to the elevation of ICAM-I, VCAM, and Å-selectin levels.