Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma

Dimitrova, Denitsa; Youroukova, Vania; Ivanova‐Todorova, Ekaterina; Tumangelova-Yuzeir, Kalina; Velikova, Tsvetelina

doi:10.1016/j.rmed.2019.06.024

Cited by 35 publications

(19 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevation in nasal lavage fluid IL-13 levels and an increase in eosinophilic inflammation were similarly found in mice exposed to PM 2.5 [61] and to PM 10 [62]. The production of nitric oxide in the airway epithelium can be induced by IL-13, which is confirmed after the blockage of IL-13 with an antagonist, resulting in reduced FeNO levels [63,64]. Although IL-13 in our subjects was measured nasally, due to the ‘united airways’ theory, it is tempting to speculate about its presence in the lower airways, which might be increased in parallel.…”

Section: Discussionmentioning

confidence: 99%

Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle: A Comparison of Airway Immune Responses

Santos

Foster

Jonckheere

et al. 2019

IJERPH

View full text Add to dashboard Cite

Although regular exercise-training improves immune/inflammatory status, the influence of air pollutants exposure during outdoor endurance training compared to a sedentary lifestyle has not yet been clarified. This study aimed to compare the immune/inflammatory responses in the airways of street runners and sedentary people after acute and chronic particulate matter (PM) exposure. Forty volunteers (street runners (RUN, n = 20); sedentary people (SED, n = 20)) were evaluated 1 (acute) and 10 (chronic) weeks after PM exposure. Cytokines [interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, IL-13, and IL-17A] in nasal lavage fluid, salivary antibacterial peptides (lactoferrin (LTF), cathelicidin (LL-37), defensin-α 1–3), and secretory immunoglobulin A (SIgA), plasma club cell protein (CC16), and fractional exhaled nitric oxide (FeNO) were analyzed. After acute exposure, the RUN group showed lower levels of IL-13, IL-10, and FeNO, but higher defensin-α than the SED group. After chronic exposure, the RUN group showed elevation of IFN-γ, IL-10, IL-17A, and a decrease of FeNO levels, whereas the SED group showed elevation of TNF-α, IL-6, IL-10, and a decrease of IL-13 levels. Comparing these groups, the RUN group showed higher levels of SIgA and LTF, and lower FeNO levels than the SED group. In relation to the Th immune response analysis after acute and chronic PM exposure, the RUN group showed a pattern associated with Th1, while in the SED group, a Th2 pattern was found. Both groups showed also a Th17 immune response pattern. Our results allow us to suggest that the immune/inflammatory status of the respiratory tract after acute and chronic PM exposure was improved by the long-standing regular practice of outdoor endurance exercise compared to a sedentary lifestyle.

show abstract

Section: Discussionmentioning

confidence: 99%

Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle: A Comparison of Airway Immune Responses

Santos

Foster

Jonckheere

et al. 2019

IJERPH

View full text Add to dashboard Cite

show abstract

“…It is known that IL-17 plays a central role in the activation of neutrophilic and macrophage in the lung in patients with COPD and severe BA [3,[9][10][11][12]. This cytokine can participate in the contraction of the airway smooth muscles and bronchial hyperreactivity and in the development of emphysema formation [13][14][15][16]. However, there are conflicting data on changes in the concentration of this cytokine in patients with COPD [17][18][19], which emphasizes the importance of studying the role of IL-17 in the development of inflammation of this disease.…”

Section: Introductionmentioning

confidence: 99%

Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma

Kubysheva

Болдина

Eliseeva

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Determination of markers of systemic inflammation is one of the important directions in the study of pathogenesis and improvement of diagnosis of chronic obstructive pulmonary disease (COPD), asthma-COPD overlap (ACO), and bronchial asthma (BA). The aim of our work was a comparative study of the features of changes in serum levels of IL-17, IL-18, and TNF-α in patients with COPD, ACO, and BA with various severity of the disease, as well as evaluation of the relationship between the level of these cytokines and lung ventilation function. A total of 147 patients with COPD (n=58), ACO (n=57), and BA (n=32) during a stable period have been examined in this study. The control group included 21 healthy nonsmokers with similar sex-age indicators. Serum levels of IL-17, IL-18, and TNF-α were determined by ELISA. The concentrations of these cytokines in the circulation in the studied patients with COPD, ACO, and BA were higher than those in healthy nonsmokers (p≤0.001). IL-17 and IL-18 levels in the blood serum were comparable in all examined patients. The mean TNF-α concentrations in the circulation in COPD and ACO were significantly higher than those in BA (p<0.001). In patients with COPD, the levels of IL-17 and TNF-α increased progressively against the background of a decrease in numerous spirometric indicators, which allows us to consider these cytokines as systemic biomarkers of disease severity. In BA, the inverse correlations between the level of IL-17 and FEV1/FVC (%) and FEV1 have been found. In patients with ACO, the increase in IL-18 levels was associated with a decrease in FEV1 and TNF-α with FEV1/FVC (%). These findings indicate that IL-17, IL-18, and TNF-α can participate in the mechanisms of systemic inflammation and the genesis of disorders of airway obstruction in COPD, AСO, and BA. An increase in the levels of IL-17 and TNF-α may be associated with impaired bronchial patency in COPD and BA. The established associations of the IL-18 concentration in the blood serum and FEV1 only in patients with ACO allow using the level of IL-18 as a potential marker of the degree of impaired airway obstruction in this disease.

show abstract

“…45 In serums from BA patients, IL-13 and IL-17A were significantly overexpressed. 46,47…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of spondin 2 eccentric expression in peripheral blood mononuclear cells in bronchial asthma

Zhou

Xiang

Wei

2021

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma

Cited by 35 publications

References 78 publications

Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle: A Comparison of Airway Immune Responses

Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle: A Comparison of Airway Immune Responses

Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma

The clinical significance of spondin 2 eccentric expression in peripheral blood mononuclear cells in bronchial asthma

Contact Info

Product

Resources

About