Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival

Huang, Yo-Ping; Chan, Cho‐Yu; Wu, Jaw‐Ching; Pai, Chung-Ho; Chao, Yee; Lee, Shou‐Dong

doi:10.1016/s0168-8278(96)80156-5

Cited by 117 publications

(57 citation statements)

References 25 publications

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“…The highest circulating IL-8 levels were shown to associate with the alcoholic hepatitis group, reaching 437 pg/ml (33). In GSD-Ia patients without HCA, serum IL-8 levels at 35.6 ± 2.3 pg/ml, were similar to that observed with the fatty liver group (33,34). On the other hand, serum IL-8 levels in HCA-bearing GSD-Ia patients at 70.6 ± 19.7 pg/ml, were higher than the values of 52 ± 8 pg/ml observed in the asymptomatic alcoholic fatty liver group (33).…”

Section: Discussionsupporting

confidence: 81%

“…In GSD-Ia patients without HCA, serum IL-8 levels at 35.6 ± 2.3 pg/ml, were similar to that observed with the fatty liver group (33,34). On the other hand, serum IL-8 levels in HCA-bearing GSD-Ia patients at 70.6 ± 19.7 pg/ml, were higher than the values of 52 ± 8 pg/ml observed in the asymptomatic alcoholic fatty liver group (33). The mild neutrophilia and moderately elevated serum IL-8 would not be expected to result in a clinical manifestation, explaining why these characteristics of GSD-Ia have not been previously reported.…”

Section: Discussionsupporting

confidence: 81%

“…Studies have shown that elevated peripheral neutrophil counts are associated with alcoholic liver disease and a correlation exists between circulating IL-8 levels and the severity of hepatic injury (33,34). The highest circulating IL-8 levels were shown to associate with the alcoholic hepatitis group, reaching 437 pg/ml (33).…”

Section: Discussionmentioning

confidence: 99%

“…Studies also show that necrotic cells can induce inflammation characterized by increased production of KC/MIP-2 and infiltrating neutrophils (36), indicating necrotic foci seen in GSD-Ia mouse liver could pose additional risk of hepatic injury. The increases in CXC chemokines along with elevated infiltrating neutrophils have been shown to associate with many liver injuries, including alcoholic liver disease and hepatocellular carcinoma (33,34,(37)(38)(39)(40)(41). Necrosis seen in mouse GSD-Ia livers that also accumulate excessive glycogen and fat suggest that neutrophil-mediated liver injuries may predispose GSD-Ia patients to develop HCA.…”

Section: Discussionmentioning

confidence: 99%

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Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia

Kim

Weinstein

Starost

et al. 2008

Journal of Hepatology

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Background/Aims-Glycogen storage disease type Ia (GSD-Ia) patients manifest the long-term complication of hepatocellular adenoma (HCA) of unknown etiology. We showed previously that GSD-Ia mice exhibit neutrophilia and elevated serum cytokine levels. This study was conducted to evaluate whether human GSD-Ia patients exhibit analogous increases and whether in GSD-Ia mice a correlation exists between immune abnormalities and, biochemical and histological alterations in the liver.Methods-Differential leukocyte counts and cytokine levels were investigated in GSD-Ia patients. Hepatic chemokine production, neutrophil infiltration, and histological abnormalities were investigated in GSD-Ia mice.Results-We show that GSD-Ia patients exhibit increased peripheral neutrophil counts and serum interleukin-8 (IL-8). Compared to normal subjects, HCA-bearing GSD-Ia patients have a 2.8-fold higher serum IL8 concentration, while GSD-Ia patients without HCA have a 1.4-fold higher concentration. Hepatic injury in GSD-Ia mice is evidenced by necrotic foci, markedly elevated infiltrating neutrophils, and increased hepatic production of chemokines.Conclusion-Peripheral neutrophilia and elevated serum chemokines are characteristic of GSDIa with HCA-bearing GSD-Ia patients having the highest serum IL-8. In GSD-Ia mice these elevations correlate with elevated hepatic chemokine levels, neutrophil infiltration, and necrosis. Taken together, peripheral neutrophilia and increased serum chemokines may indicate hepatic injuries in GSD-Ia

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia

Kim

Weinstein

Starost

et al. 2008

Journal of Hepatology

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“…P r e v a l e n c e o f COP D a n d De t a i l s o f L i v e r Di s e a s e s tivation and mRNA stabilization (27). An elevation of the serum level of IL-8 has also been observed in patients with nonalcoholic steatohepatitis (30) and those with alcoholic liver disease (31) (1,32). It has been reported that the exhaled NO level is increased in liver cirrhosis (33,34), and the expression of pulmonary vascular NO synthase (NOS) is increased in hepatopulmonary syndrome (35)(36)(37) …”

Section: Smoking Is a Major Risk Factor For Copd And Aging Increases mentioning

confidence: 99%

Prevalence of COPD in Primary Care Clinics: Correlation with Non-Respiratory Diseases

et al. 2008

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Background and Objective Various extrapulmonary effects and comorbidities have been noted to contribute to the burden of chronic obstructive pulmonary disease (COPD). However, the relationship between the prevalence of COPD and non-respiratory diseases has not been well investigated. The aim of the present study was to determine whether or not COPD is different among patients already suffering from other diseases.

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Alcohol: Behavioral and Medical Effects

Brick

2009

Wiley Encyclopedia of Forensic Science

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This article reviews the behavioral and medical consequences of alcohol. Alcohol, more than any other drug, is a common finding in toxicology and forensic medicine and proper understanding of its effects is critical to the interpretation of forensic evidence. Acute intoxication results in increased risk for and is a contributing factor in a variety of injuries including driving, fall‐downs, bicycling, thermal, water sport, aircraft operation, and suicide. Intoxication may also affect the outcome of certain types of injuries and shortens life. Chronic alcohol abuse also increases risk and injuries of the nature often encountered in forensic evaluations because of frequent intoxication to high blood‐alcohol concentrations. Physiological changes, such as in bone density and liver pathology can affect injury severity, behavior, pharmacokinetics, and life span.

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Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival

Cited by 117 publications

References 25 publications

Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia

Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia

Prevalence of COPD in Primary Care Clinics: Correlation with Non-Respiratory Diseases

Alcohol: Behavioral and Medical Effects

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